The comparative effects of metabolic surgery, SGLT2i, or GLP-1RA in patients with obesity and type 2 diabetes: a retrospective cohort study
| العنوان: | The comparative effects of metabolic surgery, SGLT2i, or GLP-1RA in patients with obesity and type 2 diabetes: a retrospective cohort study |
|---|---|
| المؤلفون: | Tingting Wu, Carlos K.H. Wong, Eric H.M. Tang, Kenneth K.C. Man, Simon K.H. Wong, Ivan Chi Ho Au, Emily T.Y. Tse, Esther W.Y. Chan, Eleanor Grieve, Olivia Wu, Enders K.W. Ng, Ian C.K. Wong |
| المصدر: | Surgery for Obesity and Related Diseases. 18:762-771 |
| بيانات النشر: | Elsevier BV, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Diabetes Mellitus, Type 2, Weight Loss, Bariatric Surgery, Humans, Hypoglycemic Agents, Surgery, Obesity, Sodium-Glucose Transporter 2 Inhibitors, Glucagon-Like Peptide-1 Receptor, Retrospective Studies |
| الوصف: | New antidiabetic agents (sodium-glucose cotransporter-2 inhibitor [SGLT2i] and glucagon-like peptide-1 receptor agonist [GLP-1RA]) and metabolic surgery have protective effects on metabolic syndromes.To compare the changes of metabolic parameters and costs among patients with obesity and type 2 diabetes undergoing metabolic surgery and initiating new antidiabetic agents over 12 months.Hong Kong Hospital Authority database from 2006-2017.This is a population-wide retrospective cohort study consisting of 2616 patients (1810 SGLT2i, 528 GLP-1RA, 278 metabolic surgery). Inverse probability treatment weighting of propensity score was applied to balance baseline covariates of patients with obesity and type 2 diabetes who underwent metabolic surgery, or initiated SGLT2i or GLP-1RA. Metabolic parameters and direct medical costs were measured and compared from baseline to 12 months in metabolic surgery, SGLT2i, and GLP-1RA groups.Patients in all 3 groups had improved metabolic parameters over a 12-month period. Patients with metabolic surgery achieved significantly better outcomes in BMI (-5.39, -.56, -.40 kg/mBeneficial weight loss and metabolic outcomes at 12 months were observed in all 3 groups, among which the metabolic surgery group showed the most remarkable effects but incurred the greatest medical costs. However, studies with a longer follow-up period are warranted to show long-term outcomes. |
| تدمد: | 1550-7289 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::131f755ac2e5c16714e762305ca5a845Test https://doi.org/10.1016/j.soard.2022.02.008Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....131f755ac2e5c16714e762305ca5a845 |
| قاعدة البيانات: | OpenAIRE |
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