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Galectin-1–driven T cell exclusion in the tumor endothelium promotes immunotherapy resistance

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العنوان:	Galectin-1–driven T cell exclusion in the tumor endothelium promotes immunotherapy resistance
المؤلفون:	A. Dimitrios Colevas, Joshua Bloomstein, Rie von Eyben, Clint T. Allen, Vangipuram S. Rangan, Todd A. Aguilera, Albert C. Koong, Quynh-Thu Le, Dadi Jiang, Hongbin Cao, Christina S. Kong, Shirley Kwok, Amato J. Giaccia, Alan J. Korman, Sonya Agarwal, Rachel Liang, Dhanya Nambiar, Zemin Wang, Ravindra Uppaluri
المصدر:	J Clin Invest
بيانات النشر:	American Society for Clinical Investigation, 2019.
سنة النشر:	2019
مصطلحات موضوعية:	Adult, Male, 0301 basic medicine, Firearms, Galectin 1, Galectins, medicine.medical_treatment, T cell, T-Lymphocytes, Programmed Cell Death 1 Receptor, B7-H1 Antigen, 03 medical and health sciences, Mice, 0302 clinical medicine, Immune system, Downregulation and upregulation, Immune Tolerance, Medicine, Animals, Humans, Endothelium, Aged, Aged, 80 and over, business.industry, General Medicine, Immunotherapy, Middle Aged, Blockade, Mice, Inbred C57BL, Radiation therapy, carbohydrates (lipids), STAT1 Transcription Factor, 030104 developmental biology, medicine.anatomical_structure, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, Galectin-1, Commentary, T cell migration, Cancer research, Female, business, Research Article
الوصف:	Cancer immunotherapy and its budding effectiveness at improving patient outcomes has revitalized our hope to fight cancer in a logical and safe manner. Immunotherapeutic approaches to reengage the immune system have largely focused on reversing immune checkpoint inhibitor pathways, which suppress the antitumor response. Although these approaches have generated much excitement, they still lack absolute success. Interestingly, newly described host-tumor sugar chains (glycosylations) and glycosylation-binding proteins (lectins) play key roles in evading the immune system to determine cancer progression. In this issue of the JCI, Nambiar et al. used patient head and neck tumors and a mouse model system to investigate the role of galactose-binding lectin 1 (Gal1) in immunotherapy resistance. The authors demonstrated that Gal1 can affect immune checkpoint inhibitor therapy by increasing immune checkpoint molecules and immunosuppressive signaling in the tumor. Notably, these results suggest that targeting a tumor’s glycobiological state will improve treatment efficacy.
اللغة:	English
الوصول الحر:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ae2195bd4106f7d6202d49886da83dTest https://europepmc.org/articles/PMC6877340Test/
حقوق:	OPEN
رقم الانضمام:	edsair.doi.dedup.....10ae2195bd4106f7d6202d49886da83d
قاعدة البيانات:	OpenAIRE

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