Methylphenidate improves executive functions in patients with traumatic brain injuries: a feasibility trial via the idiographic approach

التفاصيل البيبلوغرافية
العنوان: Methylphenidate improves executive functions in patients with traumatic brain injuries: a feasibility trial via the idiographic approach
المؤلفون: Al-Adawi, Samir, Al-Naamani, Aziz, Jaju, Sanjay, Al-Farsi, Yahya M., Dorvlo, Atsu S. S., Al-Maashani, Ali, Al-Adawi, Sara S. H., Moustafa, Ahmed A., Al-Sibani, Nasser, Essa, Musthafa M., Burke, David T., Qoronfleh, M. Walid
المصدر: BMC Neurology, Vol 20, Iss 1, Pp 1-14 (2020)
BMC Neurology
بيانات النشر: Manara - Qatar Research Repository, 2022.
سنة النشر: 2022
مصطلحات موضوعية: Adult, Male, Adolescent, Oman, Psychopharmacology, Clinical sciences, Anxiety, lcsh:RC346-429, Executive Function, Young Adult, Traumatic brain injury, Cognition, Brain Injuries, Traumatic, TBI, Humans, lcsh:Neurology. Diseases of the nervous system, IQCODE, Depression, FOS: Clinical medicine, Neurosciences, Ritalin, Methylphenidate, Feasibility Studies, Central Nervous System Stimulants, Female, Executive functioning, Research Article
الوصف: Background Road traffic accidents are known to be the main cause of traumatic brain injury (TBI). TBI is also a leading cause of death and disability. This study, by means of the idiographic approach (single-case experimental designs using multiple-baseline designs), has examined whether methylphenidate (MPH - trade name Ritalin) had a differential effect on cognitive measures among patients with TBI with the sequel of acute and chronic post-concussion syndromes. The effect on gender was also explored. Methods In comparison with healthy controls, patients with TBI (acute and chronic) and accompanying mild cognitive impairment (MCI) were screened for their integrity of executive functioning. Twenty-four patients exhibiting executive dysfunction (ED) were then instituted with the pharmacological intervention methylphenidate (MPH). The methylphenidate was administered using an uncontrolled, open label design. Results The administration of methylphenidate impacted ED in the TBI group but had no effect on mood. Attenuation of ED was more apparent in the chronic phases of TBI. The effect on gender was not statistically significant with regard to the observed changes. Conclusions To our knowledge, this is the first feasibility trial from the Arabian Gulf to report the performance of a TBI population with mild cognitive impairment according to the IQCODE Arabic version. This investigation confirms anecdotal observations of methylphenidate having the potential to attenuate cognitive impairment; particularly those functions that are critically involved in the integrity of executive functioning. The present feasibility trial should be followed by nomothetic studies such as those that adhere to the protocol of the randomized controlled trial. This evidence-based research is the foundation for intervention and future resource allocation by policy- or public health decision-makers.Other Information Published in: BMC Neurology License: http://creativecommons.org/licenses/by/4.0/SeeTest article on publisher's website: http://dx.doi.org/10.1186/s12883-020-01663-xTest
DOI: 10.57945/manara.21598311
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a453152537855521314b6874d779889Test
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....0a453152537855521314b6874d779889
قاعدة البيانات: OpenAIRE
ResultId 1
Header edsair
OpenAIRE
edsair.doi.dedup.....0a453152537855521314b6874d779889
874
3

unknown
874.047973632813
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsair&AN=edsair.doi.dedup.....0a453152537855521314b6874d779889&custid=s6537998&authtype=sso
FullText Array ( [Availability] => 0 )
Items Array ( [Name] => Title [Label] => Title [Group] => Ti [Data] => Methylphenidate improves executive functions in patients with traumatic brain injuries: a feasibility trial via the idiographic approach )
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Al-Adawi%2C+Samir%22">Al-Adawi, Samir</searchLink><br /><searchLink fieldCode="AR" term="%22Al-Naamani%2C+Aziz%22">Al-Naamani, Aziz</searchLink><br /><searchLink fieldCode="AR" term="%22Jaju%2C+Sanjay%22">Jaju, Sanjay</searchLink><br /><searchLink fieldCode="AR" term="%22Al-Farsi%2C+Yahya+M%2E%22">Al-Farsi, Yahya M.</searchLink><br /><searchLink fieldCode="AR" term="%22Dorvlo%2C+Atsu+S%2E+S%2E%22">Dorvlo, Atsu S. S.</searchLink><br /><searchLink fieldCode="AR" term="%22Al-Maashani%2C+Ali%22">Al-Maashani, Ali</searchLink><br /><searchLink fieldCode="AR" term="%22Al-Adawi%2C+Sara+S%2E+H%2E%22">Al-Adawi, Sara S. H.</searchLink><br /><searchLink fieldCode="AR" term="%22Moustafa%2C+Ahmed+A%2E%22">Moustafa, Ahmed A.</searchLink><br /><searchLink fieldCode="AR" term="%22Al-Sibani%2C+Nasser%22">Al-Sibani, Nasser</searchLink><br /><searchLink fieldCode="AR" term="%22Essa%2C+Musthafa+M%2E%22">Essa, Musthafa M.</searchLink><br /><searchLink fieldCode="AR" term="%22Burke%2C+David+T%2E%22">Burke, David T.</searchLink><br /><searchLink fieldCode="AR" term="%22Qoronfleh%2C+M%2E+Walid%22">Qoronfleh, M. Walid</searchLink> )
Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => BMC Neurology, Vol 20, Iss 1, Pp 1-14 (2020)<br />BMC Neurology )
Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => Manara - Qatar Research Repository, 2022. )
Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2022 )
Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22Adult%22">Adult</searchLink><br /><searchLink fieldCode="DE" term="%22Male%22">Male</searchLink><br /><searchLink fieldCode="DE" term="%22Adolescent%22">Adolescent</searchLink><br /><searchLink fieldCode="DE" term="%22Oman%22">Oman</searchLink><br /><searchLink fieldCode="DE" term="%22Psychopharmacology%22">Psychopharmacology</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+sciences%22">Clinical sciences</searchLink><br /><searchLink fieldCode="DE" term="%22Anxiety%22">Anxiety</searchLink><br /><searchLink fieldCode="DE" term="%22lcsh%3ARC346-429%22">lcsh:RC346-429</searchLink><br /><searchLink fieldCode="DE" term="%22Executive+Function%22">Executive Function</searchLink><br /><searchLink fieldCode="DE" term="%22Young+Adult%22">Young Adult</searchLink><br /><searchLink fieldCode="DE" term="%22Traumatic+brain+injury%22">Traumatic brain injury</searchLink><br /><searchLink fieldCode="DE" term="%22Cognition%22">Cognition</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+Injuries%2C+Traumatic%22">Brain Injuries, Traumatic</searchLink><br /><searchLink fieldCode="DE" term="%22TBI%22">TBI</searchLink><br /><searchLink fieldCode="DE" term="%22Humans%22">Humans</searchLink><br /><searchLink fieldCode="DE" term="%22lcsh%3ANeurology%2E+Diseases+of+the+nervous+system%22">lcsh:Neurology. Diseases of the nervous system</searchLink><br /><searchLink fieldCode="DE" term="%22IQCODE%22">IQCODE</searchLink><br /><searchLink fieldCode="DE" term="%22Depression%22">Depression</searchLink><br /><searchLink fieldCode="DE" term="%22FOS%3A+Clinical+medicine%22">FOS: Clinical medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Neurosciences%22">Neurosciences</searchLink><br /><searchLink fieldCode="DE" term="%22Ritalin%22">Ritalin</searchLink><br /><searchLink fieldCode="DE" term="%22Methylphenidate%22">Methylphenidate</searchLink><br /><searchLink fieldCode="DE" term="%22Feasibility+Studies%22">Feasibility Studies</searchLink><br /><searchLink fieldCode="DE" term="%22Central+Nervous+System+Stimulants%22">Central Nervous System Stimulants</searchLink><br /><searchLink fieldCode="DE" term="%22Female%22">Female</searchLink><br /><searchLink fieldCode="DE" term="%22Executive+functioning%22">Executive functioning</searchLink><br /><searchLink fieldCode="DE" term="%22Research+Article%22">Research Article</searchLink> )
Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => Background Road traffic accidents are known to be the main cause of traumatic brain injury (TBI). TBI is also a leading cause of death and disability. This study, by means of the idiographic approach (single-case experimental designs using multiple-baseline designs), has examined whether methylphenidate (MPH - trade name Ritalin) had a differential effect on cognitive measures among patients with TBI with the sequel of acute and chronic post-concussion syndromes. The effect on gender was also explored. Methods In comparison with healthy controls, patients with TBI (acute and chronic) and accompanying mild cognitive impairment (MCI) were screened for their integrity of executive functioning. Twenty-four patients exhibiting executive dysfunction (ED) were then instituted with the pharmacological intervention methylphenidate (MPH). The methylphenidate was administered using an uncontrolled, open label design. Results The administration of methylphenidate impacted ED in the TBI group but had no effect on mood. Attenuation of ED was more apparent in the chronic phases of TBI. The effect on gender was not statistically significant with regard to the observed changes. Conclusions To our knowledge, this is the first feasibility trial from the Arabian Gulf to report the performance of a TBI population with mild cognitive impairment according to the IQCODE Arabic version. This investigation confirms anecdotal observations of methylphenidate having the potential to attenuate cognitive impairment; particularly those functions that are critically involved in the integrity of executive functioning. The present feasibility trial should be followed by nomothetic studies such as those that adhere to the protocol of the randomized controlled trial. This evidence-based research is the foundation for intervention and future resource allocation by policy- or public health decision-makers.Other Information Published in: BMC Neurology License: http://creativecommons.org/licenses/by/4.0/See article on publisher's website: http://dx.doi.org/10.1186/s12883-020-01663-x )
Array ( [Name] => DOI [Label] => DOI [Group] => ID [Data] => 10.57945/manara.21598311 )
Array ( [Name] => URL [Label] => Access URL [Group] => URL [Data] => <link linkTarget="URL" linkTerm="https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a453152537855521314b6874d779889" linkWindow="_blank">https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a453152537855521314b6874d779889</link> )
Array ( [Name] => Copyright [Label] => Rights [Group] => Cpyrght [Data] => OPEN )
Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsair.doi.dedup.....0a453152537855521314b6874d779889 )
RecordInfo Array ( [BibEntity] => Array ( [Identifiers] => Array ( [0] => Array ( [Type] => doi [Value] => 10.57945/manara.21598311 ) ) [Languages] => Array ( [0] => Array ( [Text] => Undetermined ) ) [Subjects] => Array ( [0] => Array ( [SubjectFull] => Adult [Type] => general ) [1] => Array ( [SubjectFull] => Male [Type] => general ) [2] => Array ( [SubjectFull] => Adolescent [Type] => general ) [3] => Array ( [SubjectFull] => Oman [Type] => general ) [4] => Array ( [SubjectFull] => Psychopharmacology [Type] => general ) [5] => Array ( [SubjectFull] => Clinical sciences [Type] => general ) [6] => Array ( [SubjectFull] => Anxiety [Type] => general ) [7] => Array ( [SubjectFull] => lcsh:RC346-429 [Type] => general ) [8] => Array ( [SubjectFull] => Executive Function [Type] => general ) [9] => Array ( [SubjectFull] => Young Adult [Type] => general ) [10] => Array ( [SubjectFull] => Traumatic brain injury [Type] => general ) [11] => Array ( [SubjectFull] => Cognition [Type] => general ) [12] => Array ( [SubjectFull] => Brain Injuries, Traumatic [Type] => general ) [13] => Array ( [SubjectFull] => TBI [Type] => general ) [14] => Array ( [SubjectFull] => Humans [Type] => general ) [15] => Array ( [SubjectFull] => lcsh:Neurology. Diseases of the nervous system [Type] => general ) [16] => Array ( [SubjectFull] => IQCODE [Type] => general ) [17] => Array ( [SubjectFull] => Depression [Type] => general ) [18] => Array ( [SubjectFull] => FOS: Clinical medicine [Type] => general ) [19] => Array ( [SubjectFull] => Neurosciences [Type] => general ) [20] => Array ( [SubjectFull] => Ritalin [Type] => general ) [21] => Array ( [SubjectFull] => Methylphenidate [Type] => general ) [22] => Array ( [SubjectFull] => Feasibility Studies [Type] => general ) [23] => Array ( [SubjectFull] => Central Nervous System Stimulants [Type] => general ) [24] => Array ( [SubjectFull] => Female [Type] => general ) [25] => Array ( [SubjectFull] => Executive functioning [Type] => general ) [26] => Array ( [SubjectFull] => Research Article [Type] => general ) ) [Titles] => Array ( [0] => Array ( [TitleFull] => Methylphenidate improves executive functions in patients with traumatic brain injuries: a feasibility trial via the idiographic approach [Type] => main ) ) ) [BibRelationships] => Array ( [HasContributorRelationships] => Array ( [0] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Al-Adawi, Samir ) ) ) [1] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Al-Naamani, Aziz ) ) ) [2] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Jaju, Sanjay ) ) ) [3] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Al-Farsi, Yahya M. ) ) ) [4] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Dorvlo, Atsu S. S. ) ) ) [5] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Al-Maashani, Ali ) ) ) [6] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Al-Adawi, Sara S. H. ) ) ) [7] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Moustafa, Ahmed A. ) ) ) [8] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Al-Sibani, Nasser ) ) ) [9] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Essa, Musthafa M. ) ) ) [10] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Burke, David T. ) ) ) [11] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Qoronfleh, M. Walid ) ) ) ) [IsPartOfRelationships] => Array ( [0] => Array ( [BibEntity] => Array ( [Dates] => Array ( [0] => Array ( [D] => 01 [M] => 01 [Type] => published [Y] => 2022 ) ) [Identifiers] => Array ( [0] => Array ( [Type] => issn-locals [Value] => edsair ) [1] => Array ( [Type] => issn-locals [Value] => edsairFT ) ) ) ) ) ) )
IllustrationInfo