The microheterogeneities of thyroxine-binding globulin and alpha 1 protease inhibitor (alpha 1-antitrypsin) are interrelated
العنوان: | The microheterogeneities of thyroxine-binding globulin and alpha 1 protease inhibitor (alpha 1-antitrypsin) are interrelated |
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المؤلفون: | Matthew Dick, John P. Beilby, Peter Kay, Frank E. Watson |
المصدر: | Clinica chimica acta; international journal of clinical chemistry. 133(1) |
سنة النشر: | 1983 |
مصطلحات موضوعية: | Globulin, Pi system, Chemical Phenomena, Clinical Biochemistry, Biochemistry, Thyroxine-binding globulin, Thyroxine-Binding Proteins, Autoradiograph, alpha 1-Antitrypsin Deficiency, medicine, Pi, Humans, Antiserum, biology, Isoelectric focusing, Chemistry, Biochemistry (medical), General Medicine, Molecular biology, Protease inhibitor (biology), Phenotype, alpha 1-Antitrypsin, biology.protein, Isoelectric Focusing, medicine.drug, Densitometry |
الوصف: | Addition of 125 I-thyroxine to serum allows autoradiography for thyroxine-binding globulin microheterogeneity to be carried out after isoelectric focusing has been performed to display (by protein stain) the heterogeneous bands of the α 1 -antitrypsin (PI) system. Comparison of the protein stain for PI with the autoradiograph for thyroxine-binding globulin indicates that these two systems are interrelated with the major bands of the PI system corresponding to the bands on the autoradiograph. This correspondence holds for PI variants other than the common M type and in particular it holds for the deficient Z type in which the autoradiograph for thyroxine-binding globulin is strikingly different from normal. We conclude that the major cause of microheterogeneity of TBG is due to an association with the PI system under the conditions of isoelectric focusing as normally performed. Precipitation experiments with antisera to PI and TBG suggest that the complex between these biologically important globulins may occur under conditions other than isoelectric focusing, but further work will be needed to examine this possibility. |
تدمد: | 0009-8981 |
الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06efc1b8d29398fbc61298f6e20aea63Test https://pubmed.ncbi.nlm.nih.gov/6414740Test |
حقوق: | CLOSED |
رقم الانضمام: | edsair.doi.dedup.....06efc1b8d29398fbc61298f6e20aea63 |
قاعدة البيانات: | OpenAIRE |
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