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Effect of Laparoscopic Sleeve Gastrectomy on Static and Dynamic Measures of Glucose Homeostasis and Incretin Hormone Response 4-Years Post-Operatively

التفاصيل البيبلوغرافية
العنوان:	Effect of Laparoscopic Sleeve Gastrectomy on Static and Dynamic Measures of Glucose Homeostasis and Incretin Hormone Response 4-Years Post-Operatively
المؤلفون:	Sarah L. Prior, Rachel Churm, Jeffrey W. Stephens, Jonathan D. Barry, Thinzar Min, Gareth Dunseath
المصدر:	Obesity Surgery. 30:46-55
بيانات النشر:	Springer Science and Business Media LLC, 2019.
سنة النشر:	2019
مصطلحات موضوعية:	Adult, Blood Glucose, Male, endocrine system, medicine.medical_specialty, Sleeve gastrectomy, Time Factors, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, 030209 endocrinology & metabolism, Gastric Inhibitory Polypeptide, Carbohydrate metabolism, Incretins, 03 medical and health sciences, 0302 clinical medicine, Gastrectomy, Glucagon-Like Peptide 1, Internal medicine, Diabetes mellitus, medicine, Homeostasis, Humans, Insulin, Glucose homeostasis, Postoperative Period, Prospective Studies, Prospective cohort study, Nutrition and Dietetics, C-Peptide, business.industry, Area under the curve, Glucose Tolerance Test, Middle Aged, medicine.disease, Obesity, Morbid, Glucose, Endocrinology, Female, Laparoscopy, 030211 gastroenterology & hepatology, Surgery, Blood sugar regulation, business, hormones, hormone substitutes, and hormone antagonists, Follow-Up Studies
الوصف:	There is limited literature available on the long-term effect of bariatric surgery especially laparoscopic sleeve gastrectomy (LSG) on the incretin hormone response. Our primary aim was to investigate changes in glucose metabolism and incretin hormone responses in participants with impaired glucose regulation approximately 4 years after LSG. The secondary aim was to examine the long-term incretin hormone changes of biliopancreatic diversion (BPD). A non-randomised prospective study comprising of 10 participants undergoing LSG and 6 participants undergoing BPD. Serial measurements of glucose, insulin, C-peptide, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) were performed during an oral glucose tolerance test pre-operatively and 1 month, 6 months and at approximately 4–7 years post-operatively. Area under the curve (AUC) was examined at 60 and 120 min. In the LSG group, a significant reduction in 2-h plasma glucose (2 h PG), HbA1c and HOMA-IR was observed at 4 years. Compared with pre-operative levels, significant increases in post-glucose GLP-1 secretion were observed at 1 and 6 months, but not maintained at 4 years. A linear increase was seen in post-glucose GIP response at 1 month and 6 months and 4 years. Within the BPD group, a reduction in HbA1c along with an increase GLP-1 response was observed at 7 years. An increase in GLP-1 response was not preserved at 4 years, but a significant increase in GIP response was observed along with improved glycaemic control following LSG.
تدمد:	1708-0428 0960-8923
الوصول الحر:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::006c7c0096b7cd1c7f90c370d240a407Test https://doi.org/10.1007/s11695-019-04116-8Test
حقوق:	OPEN
رقم الانضمام:	edsair.doi.dedup.....006c7c0096b7cd1c7f90c370d240a407
قاعدة البيانات:	OpenAIRE

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Our primary aim was to investigate changes in glucose metabolism and incretin hormone responses in participants with impaired glucose regulation approximately 4 years after LSG. The secondary aim was to examine the long-term incretin hormone changes of biliopancreatic diversion (BPD). A non-randomised prospective study comprising of 10 participants undergoing LSG and 6 participants undergoing BPD. Serial measurements of glucose, insulin, C-peptide, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) were performed during an oral glucose tolerance test pre-operatively and 1 month, 6 months and at approximately 4–7 years post-operatively. Area under the curve (AUC) was examined at 60 and 120 min. In the LSG group, a significant reduction in 2-h plasma glucose (2 h PG), HbA1c and HOMA-IR was observed at 4 years. Compared with pre-operative levels, significant increases in post-glucose GLP-1 secretion were observed at 1 and 6 months, but not maintained at 4 years. A linear increase was seen in post-glucose GIP response at 1 month and 6 months and 4 years. Within the BPD group, a reduction in HbA1c along with an increase GLP-1 response was observed at 7 years. 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