Glucagon therapeutics: Dawn of a new era for diabetes care
العنوان: | Glucagon therapeutics: Dawn of a new era for diabetes care |
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المؤلفون: | William L. Holland, Young H Lee, Roger H Unger, Michael G. Roth, Philipp E. Scherer, Xinxin Yu, May-Yun Wang, Jaime A. Davidson, Sara Kay McCorkle |
المصدر: | Diabetes/Metabolism Research and Reviews. 32:660-665 |
بيانات النشر: | Wiley, 2016. |
سنة النشر: | 2016 |
مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Type 1 diabetes, business.industry, Endocrinology, Diabetes and Metabolism, Insulin, medicine.medical_treatment, 030209 endocrinology & metabolism, Type 2 diabetes, medicine.disease, Glucagon, Diabetes Therapy, Ketoacidosis, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Endocrinology, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Intensive care medicine, business, Glucagon receptor |
الوصف: | Although insulin monotherapy prevents death from ketoacidosis, it does not prevent either the hyperglycemic surges or the hypoglycemic plunges of glucose levels that plague the majority of patients with type 1 diabetes. However, significant improvements have occurred with the combination of continuous insulin delivery matched by continuous glucose monitoring, but the technology is not available for all patients, requires extensive education, is expensive and moreover, while much better than standard care, it almost never reduces haemoglobin A1c (HbA1c ) to below 6%. This may indicate that an improved diabetes therapy involving antagonism of glucagon action will for the first time control glucose levels to normal and eradicate the long-term complications of diabetes. Although one can never predict that results in animals will be reproduced in humans, the available evidence suggests that patients with type 1 and type 2 diabetes may expect far superior control of the metabolic abnormalities without the need for significant monitoring of glucose, a very important but expensive part of any insulin regimen. |
تدمد: | 1520-7552 |
الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::ef390ca468adfed2f255b576d1c78156Test https://doi.org/10.1002/dmrr.2773Test |
حقوق: | CLOSED |
رقم الانضمام: | edsair.doi...........ef390ca468adfed2f255b576d1c78156 |
قاعدة البيانات: | OpenAIRE |
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