Polyphenolic Profile, Anti-Inflammatory and Antinociceptive Activity of an Extract from Arctium lappa L. Roots
| العنوان: | Polyphenolic Profile, Anti-Inflammatory and Antinociceptive Activity of an Extract from Arctium lappa L. Roots |
|---|---|
| المؤلفون: | Simona Conea, Claudia Crina Toma, Oliviu Vostinaru, Irina Cazacu, Laurian Vlase, Cristina Pop, Ioana Cuc Hepcal, Cristina Mogosan |
| المصدر: | Notulae Botanicae Horti Agrobotanici Cluj-Napoca. 45:59-64 |
| بيانات النشر: | University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0106 biological sciences, Traditional medicine, medicine.drug_class, Stereochemistry, Plant Science, Horticulture, 01 natural sciences, Quercitrin, Anti-inflammatory, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Acetic acid, chemistry.chemical_compound, Nociception, chemistry, Chlorogenic acid, Polyphenol, Randall–Selitto test, Arctium lappa, medicine, Agronomy and Crop Science, 010606 plant biology & botany |
| الوصف: | The aim of the study was to assess the polyphenolic profile, anti-inflammatory and antinociceptive activity of Arctium lappa, a medicinal plant traditionally used in the treatment of gout, hepatitis and other inflammatory disorders. Polyphenolic profile of a hydro-glycero-ethanolic extract from Arctium lappa roots (ALE) was evaluated by HPLC-MS method. Anti-inflammatory effect of the Arctium lappa extract (ALE) was determined by carrageenan-induced rat paw oedema test, while antinociceptive effect was determined by acetic acid induced writhing test in mice and Randall Selitto test in rats. HPLC-MS analysis of the extract showed the presence of chlorogenic acid (158.9 μg/mL) and quercitrin (14.4 μg/mL). The administration of ALE reduced the oedema formation in the carrageenan-induced rat paw oedema test, especially at dose of 500 mg/kg, the results being statistically significant and dose-dependent. Also, ALE showed statistically significant and dose-dependent antinociceptive effects in the acetic acid induced writhing test in mice and Randall Selitto test in rats. The results of the pharmacological experiments suggest that the anti-inflammatory and antinociceptive effects of the Arctium lappa extract (ALE) may be related to the ability of polyphenols such as chlorogenic acid to inhibit the synthesis and release of some pro-inflammatory mediators. Our experimental data justify the traditional use of this plant in the management of some inflammatory disease. |
| تدمد: | 1842-4309 0255-965X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::ec14047abe32e021b33d1e5d7a9a0612Test https://doi.org/10.15835/nbha45110549Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........ec14047abe32e021b33d1e5d7a9a0612 |
| قاعدة البيانات: | OpenAIRE |
| ResultId |
1 |
|---|---|
| Header |
edsair OpenAIRE edsair.doi...........ec14047abe32e021b33d1e5d7a9a0612 833 3 unknown 832.623229980469 |
| PLink |
https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsair&AN=edsair.doi...........ec14047abe32e021b33d1e5d7a9a0612&custid=s6537998&authtype=sso |
| FullText |
Array
(
[Availability] => 0
)
|
| Items |
Array
(
[Name] => Title
[Label] => Title
[Group] => Ti
[Data] => Polyphenolic Profile, Anti-Inflammatory and Antinociceptive Activity of an Extract from Arctium lappa L. Roots
)
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Simona+Conea%22">Simona Conea</searchLink><br /><searchLink fieldCode="AR" term="%22Claudia+Crina+Toma%22">Claudia Crina Toma</searchLink><br /><searchLink fieldCode="AR" term="%22Oliviu+Vostinaru%22">Oliviu Vostinaru</searchLink><br /><searchLink fieldCode="AR" term="%22Irina+Cazacu%22">Irina Cazacu</searchLink><br /><searchLink fieldCode="AR" term="%22Laurian+Vlase%22">Laurian Vlase</searchLink><br /><searchLink fieldCode="AR" term="%22Cristina+Pop%22">Cristina Pop</searchLink><br /><searchLink fieldCode="AR" term="%22Ioana+Cuc+Hepcal%22">Ioana Cuc Hepcal</searchLink><br /><searchLink fieldCode="AR" term="%22Cristina+Mogosan%22">Cristina Mogosan</searchLink> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => <i>Notulae Botanicae Horti Agrobotanici Cluj-Napoca</i>. 45:59-64 ) Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 2017. ) Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2017 ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%220106+biological+sciences%22">0106 biological sciences</searchLink><br /><searchLink fieldCode="DE" term="%22Traditional+medicine%22">Traditional medicine</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%2Edrug%5Fclass%22">medicine.drug_class</searchLink><br /><searchLink fieldCode="DE" term="%22Stereochemistry%22">Stereochemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Plant+Science%22">Plant Science</searchLink><br /><searchLink fieldCode="DE" term="%22Horticulture%22">Horticulture</searchLink><br /><searchLink fieldCode="DE" term="%2201+natural+sciences%22">01 natural sciences</searchLink><br /><searchLink fieldCode="DE" term="%22Quercitrin%22">Quercitrin</searchLink><br /><searchLink fieldCode="DE" term="%22Anti-inflammatory%22">Anti-inflammatory</searchLink><br /><searchLink fieldCode="DE" term="%220104+chemical+sciences%22">0104 chemical sciences</searchLink><br /><searchLink fieldCode="DE" term="%22010404+medicinal+%26+biomolecular+chemistry%22">010404 medicinal & biomolecular chemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Acetic+acid%22">Acetic acid</searchLink><br /><searchLink fieldCode="DE" term="%22chemistry%2Echemical%5Fcompound%22">chemistry.chemical_compound</searchLink><br /><searchLink fieldCode="DE" term="%22Nociception%22">Nociception</searchLink><br /><searchLink fieldCode="DE" term="%22chemistry%22">chemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Chlorogenic+acid%22">Chlorogenic acid</searchLink><br /><searchLink fieldCode="DE" term="%22Polyphenol%22">Polyphenol</searchLink><br /><searchLink fieldCode="DE" term="%22Randall–Selitto+test%22">Randall–Selitto test</searchLink><br /><searchLink fieldCode="DE" term="%22Arctium+lappa%22">Arctium lappa</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%22">medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Agronomy+and+Crop+Science%22">Agronomy and Crop Science</searchLink><br /><searchLink fieldCode="DE" term="%22010606+plant+biology+%26+botany%22">010606 plant biology & botany</searchLink> ) Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => The aim of the study was to assess the polyphenolic profile, anti-inflammatory and antinociceptive activity of Arctium lappa, a medicinal plant traditionally used in the treatment of gout, hepatitis and other inflammatory disorders. Polyphenolic profile of a hydro-glycero-ethanolic extract from Arctium lappa roots (ALE) was evaluated by HPLC-MS method. Anti-inflammatory effect of the Arctium lappa extract (ALE) was determined by carrageenan-induced rat paw oedema test, while antinociceptive effect was determined by acetic acid induced writhing test in mice and Randall Selitto test in rats. HPLC-MS analysis of the extract showed the presence of chlorogenic acid (158.9 μg/mL) and quercitrin (14.4 μg/mL). The administration of ALE reduced the oedema formation in the carrageenan-induced rat paw oedema test, especially at dose of 500 mg/kg, the results being statistically significant and dose-dependent. Also, ALE showed statistically significant and dose-dependent antinociceptive effects in the acetic acid induced writhing test in mice and Randall Selitto test in rats. The results of the pharmacological experiments suggest that the anti-inflammatory and antinociceptive effects of the Arctium lappa extract (ALE) may be related to the ability of polyphenols such as chlorogenic acid to inhibit the synthesis and release of some pro-inflammatory mediators. Our experimental data justify the traditional use of this plant in the management of some inflammatory disease. ) Array ( [Name] => ISSN [Label] => ISSN [Group] => ISSN [Data] => 1842-4309<br />0255-965X ) Array ( [Name] => URL [Label] => Access URL [Group] => URL [Data] => <link linkTarget="URL" linkTerm="https://explore.openaire.eu/search/publication?articleId=doi_________::ec14047abe32e021b33d1e5d7a9a0612" linkWindow="_blank">https://explore.openaire.eu/search/publication?articleId=doi_________::ec14047abe32e021b33d1e5d7a9a0612</link><br /><link linkTarget="URL" linkTerm="https://doi.org/10.15835/nbha45110549" linkWindow="_blank">https://doi.org/10.15835/nbha45110549</link> ) Array ( [Name] => Copyright [Label] => Rights [Group] => Cpyrght [Data] => OPEN ) Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsair.doi...........ec14047abe32e021b33d1e5d7a9a0612 ) |
| RecordInfo |
Array
(
[BibEntity] => Array
(
[Languages] => Array
(
[0] => Array
(
[Text] => Undetermined
)
)
[PhysicalDescription] => Array
(
[Pagination] => Array
(
[PageCount] => 6
[StartPage] => 59
)
)
[Subjects] => Array
(
[0] => Array
(
[SubjectFull] => 0106 biological sciences
[Type] => general
)
[1] => Array
(
[SubjectFull] => Traditional medicine
[Type] => general
)
[2] => Array
(
[SubjectFull] => medicine.drug_class
[Type] => general
)
[3] => Array
(
[SubjectFull] => Stereochemistry
[Type] => general
)
[4] => Array
(
[SubjectFull] => Plant Science
[Type] => general
)
[5] => Array
(
[SubjectFull] => Horticulture
[Type] => general
)
[6] => Array
(
[SubjectFull] => 01 natural sciences
[Type] => general
)
[7] => Array
(
[SubjectFull] => Quercitrin
[Type] => general
)
[8] => Array
(
[SubjectFull] => Anti-inflammatory
[Type] => general
)
[9] => Array
(
[SubjectFull] => 0104 chemical sciences
[Type] => general
)
[10] => Array
(
[SubjectFull] => 010404 medicinal & biomolecular chemistry
[Type] => general
)
[11] => Array
(
[SubjectFull] => Acetic acid
[Type] => general
)
[12] => Array
(
[SubjectFull] => chemistry.chemical_compound
[Type] => general
)
[13] => Array
(
[SubjectFull] => Nociception
[Type] => general
)
[14] => Array
(
[SubjectFull] => chemistry
[Type] => general
)
[15] => Array
(
[SubjectFull] => Chlorogenic acid
[Type] => general
)
[16] => Array
(
[SubjectFull] => Polyphenol
[Type] => general
)
[17] => Array
(
[SubjectFull] => Randall–Selitto test
[Type] => general
)
[18] => Array
(
[SubjectFull] => Arctium lappa
[Type] => general
)
[19] => Array
(
[SubjectFull] => medicine
[Type] => general
)
[20] => Array
(
[SubjectFull] => Agronomy and Crop Science
[Type] => general
)
[21] => Array
(
[SubjectFull] => 010606 plant biology & botany
[Type] => general
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Polyphenolic Profile, Anti-Inflammatory and Antinociceptive Activity of an Extract from Arctium lappa L. Roots
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Simona Conea
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Claudia Crina Toma
)
)
)
[2] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Oliviu Vostinaru
)
)
)
[3] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Irina Cazacu
)
)
)
[4] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Laurian Vlase
)
)
)
[5] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Cristina Pop
)
)
)
[6] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Ioana Cuc Hepcal
)
)
)
[7] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Cristina Mogosan
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 10
[M] => 06
[Type] => published
[Y] => 2017
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-print
[Value] => 18424309
)
[1] => Array
(
[Type] => issn-print
[Value] => 0255965X
)
[2] => Array
(
[Type] => issn-locals
[Value] => edsair
)
[3] => Array
(
[Type] => issn-locals
[Value] => edsairFT
)
)
[Numbering] => Array
(
[0] => Array
(
[Type] => volume
[Value] => 45
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Notulae Botanicae Horti Agrobotanici Cluj-Napoca
[Type] => main
)
)
)
)
)
)
)
|
| IllustrationInfo |