Aged rhesus skeletal muscle: Histochemistry and lipofuscin content
| العنوان: | Aged rhesus skeletal muscle: Histochemistry and lipofuscin content |
|---|---|
| المؤلفون: | M. K. Hoskins, P. T. Herrington, C. H. Beatty, R. M. Bocek, C. Lamy |
| المصدر: | AGE. 5:1-9 |
| بيانات النشر: | Springer Science and Business Media LLC, 1982. |
| سنة النشر: | 1982 |
| مصطلحات موضوعية: | Aging, medicine.medical_specialty, Sartorius muscle, Succinic dehydrogenase, Fiber type, Skeletal muscle, General Medicine, Anatomy, Biology, Lipofuscin, Endocrinology, medicine.anatomical_structure, Human muscle, Internal medicine, medicine, Immunohistochemistry, Geriatrics and Gerontology, White area |
| الوصف: | Sections of sartorius muscle from young adult (6 to 11 yr), adult (15 to 16 yr), and aged (over 20 yr) rhesus monkeys were stained for Ca, Mg-ATPase and succinic dehydrogenase (SDH) activities. Three fiber types-type 1 (slow-twitch oxidative), type 2A (fast-twitch oxidative-glycolytic), and type 2B (fast-twitch glycolytic)-were differentiated. There was a decrease in the percent of type 2B fibers with aging. Some type of morphological pathology was seen in all sartorii from monkeys older than 15 yr, e.g., fiber degeneration and splitting, dedifferentiation, and fiber type grouping. In aged male sartorii the decreases in fiber areas were similar in all three fiber types; in aged female sartorii the areas of types 1 and 2A decreased with no change in the size of type 2B. The number of lipofuscin (LF) granules in aged muscles (monkeys more than 17 yr old) was greater than that in the muscle from young adults (under 10 yr). The increase in LF content with age was about 300% for the soleus and sartorii, and 120% for the predominantly white area of the brachioradialis. In rhesus muscle, as in human muscle, morphological changes with aging appear to be highly variable. |
| تدمد: | 1574-4647 0161-9152 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::cffdb3303791e559e793492c6e9dfbccTest https://doi.org/10.1007/bf02431717Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........cffdb3303791e559e793492c6e9dfbcc |
| قاعدة البيانات: | OpenAIRE |
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