A significant response to a combination of trastuzumab and vinorelbine in HER2-negative metastatic breast cancer with HER2 V777L mutation
العنوان: | A significant response to a combination of trastuzumab and vinorelbine in HER2-negative metastatic breast cancer with HER2 V777L mutation |
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المؤلفون: | Xiaojia Wang, Jian Huang, Ping Huang, Lei Lei, Ya-Bing Zheng, Wei-Wu Ye, Zhan-Hong Chen, Lin-Feng Zheng, Xian Wang, Lei Shi |
المصدر: | OncoTargets and Therapy. 12:2931-2936 |
بيانات النشر: | Informa UK Limited, 2019. |
سنة النشر: | 2019 |
مصطلحات موضوعية: | 0301 basic medicine, Oncology, medicine.medical_specialty, business.industry, Disease, medicine.disease, Vinorelbine, Metastatic breast cancer, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Breast cancer, Trastuzumab, 030220 oncology & carcinogenesis, Internal medicine, Mutation (genetic algorithm), medicine, Pharmacology (medical), skin and connective tissue diseases, Breast carcinoma, business, neoplasms, Tyrosine kinase, medicine.drug |
الوصف: | Metastatic breast cancer (MBC) is the most life-threatening disease in women worldwide. HER2-mutated breast carcinoma has been reported to benefit from HER2-targeted tyrosine kinase inhibitors recently. Here, we presented a heavy pretreated and harbored HER2 V777L mutation de novo stage IV Luminal B (HER2 unamplified) breast cancer patient who achieved an unexpected good response to trastuzumab combined with vinorelbine therapy. Although HER2-unamplified MBC patients do not regularly benefit from anti-HER2 target therapy, HER2 V777L mutation detected by next-generation sequencing from ctDNA may present as a predictive biomarker for anti-HER2-based strategy therapy in HER2-negative MBC patients. |
تدمد: | 1178-6930 |
الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::c0e1b9e97dd06b3c8b441b75bf4b1d96Test https://doi.org/10.2147/ott.s199931Test |
حقوق: | OPEN |
رقم الانضمام: | edsair.doi...........c0e1b9e97dd06b3c8b441b75bf4b1d96 |
قاعدة البيانات: | OpenAIRE |
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