Lasting first impression: Pre-existing immunity restricts mucosal antibody responses during Omicron breakthrough
العنوان: | Lasting first impression: Pre-existing immunity restricts mucosal antibody responses during Omicron breakthrough |
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المؤلفون: | Kevin John Selva, Pradhipa Ramanathan, Ebene Regina Haycroft, Arnold Reynaldi, Deborah Cromer, Chee Wah Tan, Lin-Fa Wang, Bruce D Wines, P Mark Hogarth, Laura E Downie, Samantha K Davis, Ruth Amy Purcell, Helen E Kent, Jennifer A Juno, Adam K Wheatley, Miles P Davenport, Stephen John Kent, Amy W Chung |
بيانات النشر: | Cold Spring Harbor Laboratory, 2023. |
سنة النشر: | 2023 |
الوصف: | SummaryUnderstanding mucosal antibody responses from SARS-CoV-2 infection and/or vaccination is crucial to develop strategies for longer term immunity, especially against emerging viral variants. We profiled serial paired mucosal and plasma antibodies from: COVID-19 vaccinated only vaccinees (vaccinated, uninfected), COVID-19 recovered vaccinees (convalescent, vaccinated) and individuals with breakthrough Delta or Omicron BA.2 infections (vaccinated, infected). Saliva from COVID-19 recovered vaccinees displayed improved antibody neutralizing activity, FcγR engagement and IgA compared to COVID-19 uninfected vaccinees. Furthermore, repeated mRNA vaccination boosted SARS-CoV-2-specific IgG2 and IgG4 responses in both mucosa biofluids (saliva and tears) and plasma. IgG, but not IgA, responses to breakthrough COVID-19 variants were dampened and narrowed by increased pre-existing vaccine-induced immunity to the ancestral strain. Salivary antibodies delayed initiation of boosting following breakthrough COVID-19 infection, especially Omicron BA.2, however, rose rapidly thereafter. Our data highlight how pre-existing immunity shapes mucosal SARS-CoV-2-specific antibody responses and has implications for long-term protection from COVID-19. |
الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::9007e798bc0d3de77a7f5c418ba1ad8cTest https://doi.org/10.1101/2023.03.28.23287848Test |
رقم الانضمام: | edsair.doi...........9007e798bc0d3de77a7f5c418ba1ad8c |
قاعدة البيانات: | OpenAIRE |