E-cadherin expression in four kinds of carcinomas and their relations to differentiation and metastasis
| العنوان: | E-cadherin expression in four kinds of carcinomas and their relations to differentiation and metastasis |
|---|---|
| المؤلفون: | Jian-min Su, li-huan Cao, Yi-ping Zhou, Xi-liang Zha, Wei-ling Xu |
| المصدر: | Chinese Journal of Cancer Research. 13:13-17 |
| بيانات النشر: | Chinese Journal of Cancer Research, 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | Cancer Research, Pathology, medicine.medical_specialty, Colorectal cancer, Cadherin, Cancer, Lymph node metastasis, Biology, medicine.disease, Metastasis, medicine.anatomical_structure, Breast cancer, Oncology, medicine, Immunohistochemistry, Lymph node |
| الوصف: | Objective: To obtain the pattern and reactivity extent of E-cadherin and correlation with clinicopathological data including tumor type, grade, and lymph node status. Methods: Expression of E-cadherin has been examined in 20 gastric carcinomas; 21 colorectal carcinomas; 20 uterocervical carcinomas and 20 breast carcinomas using an immunohistochemical technique. Results: There were similar patterns among four kinds of cancer. Tumors with a decreased E-cadherin occurred significantly more frequently in poor differentiated carcinomas. There was association between membrane levels of E-cadherin and the presence of lymph node metastasis, but the difference was not significant. Conclusions: E-cadherin expression of the noncancerous areas is higher than that of the cancerous areas. The decreased E-cadherin expression correlates with dedifferentiation. The relation between the E-cadherin expression and the metastasis is complex and need much more research. There are similar patterns among four types of cancer. For that, immunohistochemical study of E-cadherin may have clinicopathologic value for patients with cancer. |
| تدمد: | 1993-0631 1000-9604 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::7221b56e3695672de2131bb3323b0133Test https://doi.org/10.1007/s11670-001-0004-1Test |
| رقم الانضمام: | edsair.doi...........7221b56e3695672de2131bb3323b0133 |
| قاعدة البيانات: | OpenAIRE |
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