Quaternary Structure Analyses of an Essential Oligomeric Enzyme
| العنوان: | Quaternary Structure Analyses of an Essential Oligomeric Enzyme |
|---|---|
| المؤلفون: | Shane E. Gordon, Tatiana P. Soares da Costa, Belinda M. Abbott, Chamodi K. Gardhi, John Wagner, Campbell J Hogan, Ruchi Gupta, Matthew A. Perugini, Janni B. Christensen, Santosh Panjikar, Tao G. Nelson, Matthew T. Downton, Sebastien Desbois |
| بيانات النشر: | Elsevier, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Molecular dynamics, Dihydrodipicolinate synthase, Protein structure, Biochemistry, biology, Chemistry, Protein subunit, Protein dynamics, biology.protein, Active site, Protein quaternary structure, Enzyme kinetics |
| الوصف: | Here, we review recent studies aimed at defining the importance of quaternary structure to a model oligomeric enzyme, dihydrodipicolinate synthase. This will illustrate the complementary and synergistic outcomes of coupling the techniques of analytical ultracentrifugation with enzyme kinetics, in vitro mutagenesis, macromolecular crystallography, small angle X-ray scattering, and molecular dynamics simulations, to demonstrate the role of subunit self-association in facilitating protein dynamics and enzyme function. This multitechnique approach has yielded new insights into the molecular evolution of protein quaternary structure. |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::5ff0c65421ba2b538baa2193bdb088bbTest https://doi.org/10.1016/bs.mie.2015.06.020Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........5ff0c65421ba2b538baa2193bdb088bb |
| قاعدة البيانات: | OpenAIRE |
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