The Fas system in the seminiferous epithelium and its possible extra-testicular role
العنوان: | The Fas system in the seminiferous epithelium and its possible extra-testicular role |
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المؤلفون: | Alessio D'Alessio, Antonio Filippini, Claudia Giampietri, Anna Riccioli, Elio Ziparo, Donatella Starace, P De Cesaris, Luca Salvati |
المصدر: | Andrologia. 35:64-70 |
بيانات النشر: | Hindawi Limited, 2003. |
سنة النشر: | 2003 |
مصطلحات موضوعية: | medicine.medical_specialty, Urology, hemic and immune systems, chemical and pharmacologic phenomena, General Medicine, Biology, Testicle, Sertoli cell, Fas receptor, Fas ligand, Cell biology, Endocrinology, Immune system, medicine.anatomical_structure, Seminiferous tubule, Apoptosis, Internal medicine, medicine, Germ cell |
الوصف: | The Fas system is involved in the control of immune system homeostasis and nonfunctional Fas system leads to autoimmune disease in mice and humans. The Fas system is a mechanism through which cells expressing Fas ligand (FasL) induce apoptosis of Fas expressing cells. In mouse and rat, the testis represents the main source of constitutive FasL in the body. The roles so far proposed for this molecule in the testis, such as maintenance of immunoprivilege and regulation of physiological germ cell apoptosis, need to be reconsidered as both hypotheses are based on an erroneous cellular location of FasL in the seminiferous epithelium. Recently, we demonstrated that in rodents FasL mRNA is present in germ cells and not in Sertoli cells, and that FasL protein is displayed on the surface of spermatozoa. Here we propose that, for the mouse spermatozoa, the FasL may represent a self-defence mechanism against lymphocytes present in the female genital tract. To verify this hypothesis, we performed crossings between males gld, with nonfunctional FasL, and syngenic or nonsyngenic females. We observed a significant decrease of litter size in outbred crossings with gld males compared with wild-type males, suggesting a possible role of FasL in immunoprotection of the sperm in the female genital tract. The possibility that in humans, by analogy with mouse, FasL plays a self-protective role for the spermatozoon cannot be excluded, and awaits experimental information on the expression of FasL on human sperm cells. |
تدمد: | 0303-4569 |
الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::3684edbd1eeba2c31829fa37eefa7c87Test https://doi.org/10.1046/j.1439-0272.2003.00538.xTest |
حقوق: | CLOSED |
رقم الانضمام: | edsair.doi...........3684edbd1eeba2c31829fa37eefa7c87 |
قاعدة البيانات: | OpenAIRE |