An alternatively transcribed TAZ variant negatively regulates JAK ‐ STAT signaling
| العنوان: | An alternatively transcribed |
|---|---|
| المؤلفون: | Fa-Xing Yu, Chen Ding, Peng-Cheng Yu, Kang Chen, Yubin Lei, Yufeng Zhou, Chuantao Fang, Yan Zeng, Sixian Qi, Ru-Ping Dai, Jian Li, Zhao-Lan Hu, Pinglong Xu, Shenglin Huang, Jin Li, Yulong Wang |
| المصدر: | EMBO reports. 20 |
| بيانات النشر: | EMBO, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0303 health sciences, Hippo signaling pathway, biology, Effector, JAK-STAT signaling pathway, Biochemistry, stat, Cell biology, 03 medical and health sciences, 0302 clinical medicine, Hippo signaling, Interferon, Genetics, biology.protein, medicine, STAT1, Janus kinase, Molecular Biology, 030217 neurology & neurosurgery, 030304 developmental biology, medicine.drug |
| الوصف: | Type I interferon (IFN)-induced Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling drives the expression of IFN-stimulated genes (ISGs) to mediate antiviral response. The strength and duration of JAK-STAT signaling are tightly regulated to ensure effective antiviral defense while avoiding pathological inflammation and autoimmunity. Here, we report that cTAZ, an isoform of the Hippo pathway effector TAZ, is transcribed by an alternative promoter. Although majority of C-terminal sequences of TAZ is retained, cTAZ is not regulated by the Hippo signaling and does not mediate its growth-inhibitory functions. Instead, cTAZ negatively regulates JAK-STAT signaling by inhibiting STAT1/2 nuclear localization and ISG expression, and its expression is induced by type I IFN Thus, cTAZ functions as a modulator of JAK-STAT signaling and may play a role in fine-tuning cellular antiviral response. |
| تدمد: | 1469-3178 1469-221X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::04ac9282fe86d390d882785cb14448c5Test https://doi.org/10.15252/embr.201847227Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........04ac9282fe86d390d882785cb14448c5 |
| قاعدة البيانات: | OpenAIRE |
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