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Designing a broad-spectrum integrative approach for cancer prevention and treatment

التفاصيل البيبلوغرافية
العنوان: Designing a broad-spectrum integrative approach for cancer prevention and treatment
المؤلفون: Keith I. Blocka, Charlotte Gyllenhaala, Leroy Loweb, Amedeo Amedeic, A.R.M. Ruhul Amind, Amr Amine, Katia Aquilanof, Jack Arbiserd, Alexandra Arreolag, Alla Arzumanyanh, S. Salman Ashrafi, Asfar S. Azmij, Fabian Benenciak, Dipita Bhaktal, Alan Bilslandm, Anupam Bishayeen, Stacy W. Blaino, Penny B. Blocka, Chandra S. Boosanip, Thomas E. Careyq, Amancio Carneror, Marianeve Carotenutos, t, Stephanie C. Caseyu, Mrinmay Chakrabartiv, Rupesh Chaturvediw, Georgia Zhuo Chend, Helen Chenx, Sophie Cheny, Yi Charlie Chenz, Beom K. Choiaa, Maria Rosa Ciriolo f, Helen M. Coleyab, Andrew R. Collins ac, Marisa Connellx, Sarah Crawfordad, Colleen S. Curranae, Charlotta Dabrosinaf, Giovanna Damiaag, Santanu Dasguptaah, Ralph J. DeBerardinisaj, William K. Deckerak, Punita Dhawanal, Anna Mae E. Diehlam, Jin-Tang Dongd, Q. Ping Douj, Janice E. Drewan, Eyad Elkordao, Bassel El-Rayesap, Mark A. Feitelsonh, Dean W. Felsheru, Lynnette R. Fergusonaq, Carmela Fimognariar, Gary L. Firestoneas, Christian Frezzaat, Hiromasa Fujii au, Mark M. Fusterav, Daniele Generaliaw, Alexandros G. Georgakilasay, Frank Gieseleraz, Michael Gilbertsonba, Michelle F. Greenbb, Brendan Gruebc, Gunjan Guhal, Dorota Halickabd, William G. Helferichbe, Petr Henebergbf, Patricia Hentoshbg, Matthew D. Hirscheyam, Lorne J. Hofsethbh, Randall F. Holcombebi, Kanya Honokiau, Hsue-Yin Hsubj, Gloria S. Huangbk, Lasse D. Jensenbl, Wen G. Jiangbn, Lee W. Jonesbo, Phillip A. Karpowiczbp, W. Nicol Keithm, Sid P. Kerkarbq, Gazala N. Khanbr, Mahin Khatamibs, Young H. Kobt, Omer Kucukd, Rob J. Kulathinalh, Nagi B. Kumarbu, Byoung S. Kwonaa, Anne Lebx, Michael A. Leaby, Ho-Young Leebz, Terry Lichtorca, Liang-Tzung Lincb, Jason W. Locasalecc, Bal L. Lokeshwarcd, Valter D. Longoce, Costas A. Lyssiotis cf, Karen L. MacKenziecg, Meenakshi Malhotrach, Maria Marinoci, Maria L. Martinez-Chantarcj, Ander Matheuck, Christopher Maxwellx, Eoin McDonnellbb, Alan K. Meekercl, Mahya Mehrmohamadicm, Kapil Mehtacn, Gregory A. Michelottiam, Ramzi M. Mohammadj, Sulma I. Mohammedco, D. James Morrecp, Irfana Muqbilj, Vinayak Muralidharcq, Michael P. Murphycs, Ganji Purnachandra Nagarajuap, Rita Nahtad, Elena Niccolaict, Somaira Nowsheencu, Carolina Paniscv, Francesco Pantanocw, Virginia R. Parslowaq, Graham Paweleccx, Peter L. Pedersency, Brad Poorebx, Deepak Poudyalbh, Satya Prakashch, Mark Princecz, Lizzia Raffaghelloda, Jeffrey C. Rathmellbb, W. Kimryn Rathmellg, Swapan K. Rayv, Jörg Reichrathdb, Sarallah Rezazadehdc, Domenico Ribatti dd, Luigi Ricciardiello de, R. Brooks Robeydf, Francis Rodierdh, H.P. Vasantha Rupasinghedj, Gian Luigi Russodk, Elizabeth P. Ryandl, Abbas K. Samadidm, Isidro Sanchez-Garciadn, Andrew J. Sandersbn, Daniele Santinicw, Malancha Sarkardo, Tetsuro Sasadadp, Neeraj K. Saxenadq, Rodney E. Shackelforddr, H.M.C. Shantha Kumarabv, Dipali Sharmads, Dong M. Shind, David Sidranskydt, Markus David Siegelindu, Emanuela Signoridv, Neetu Singhdw, Sharanya Sivananddx, Daniel Sliva dy, Carl Smythedz, Carmela Spagnuolodk, Diana M. Stafforini ea, John Staggeb, Pochi R. Subbarayanec, Tabetha Sundined, Wamidh H. Talibee, Sarah K. Thompsonef, Phuoc T. Traneg, Hendrik Ungefrorenaz, Matthew G. Vander Heidencr, Vasundara Venkateswaraneh, Dass S. Vinayai, Panagiotis J. Vlachostergiosei, Zongwei Wangej, Kathryn E. Wellendx, Richard L. Whelanbv, Eddy S. Yangek, Huanjie Yangel, Xujuan Yangbe, Paul Yaswenem, Clement Yedjouen, Xin Yinav, Jiyue Zhueo, Massimo Zollos
المصدر: Seminars in cancer biology 35 (2015): S276–S304. doi:10.1016/j.semcancer.2015.08.002
info:cnr-pdr/source/autori:Keith I. Blocka,*, Charlotte Gyllenhaala, Leroy Loweb,er,**, Amedeo Amedeic, A.R.M. Ruhul Amind, Amr Amine, Katia Aquilanof, Jack Arbiserd,ep,eq, Alexandra Arreolag, Alla Arzumanyanh, S. Salman Ashrafi, Asfar S. Azmij, Fabian Benenciak, Dipita Bhaktal, Alan Bilslandm, Anupam Bishayeen, Stacy W. Blaino, Penny B. Blocka, Chandra S. Boosanip, Thomas E. Careyq, Amancio Carneror, Marianeve Carotenutos,t, Stephanie C. Caseyu, Mrinmay Chakrabartiv, Rupesh Chaturvediw, Georgia Zhuo Chend, Helen Chenx, Sophie Cheny, Yi Charlie Chenz, Beom K. Choiaa, Maria Rosa Ciriolo f, Helen M. Coleyab, Andrew R. Collins ac, Marisa Connellx, Sarah Crawfordad, Colleen S. Curranae, Charlotta Dabrosinaf, Giovanna Damiaag, Santanu Dasguptaah, Ralph J. DeBerardinisaj, William K. Deckerak, Punita Dhawanal, Anna Mae E. Diehlam, Jin-Tang Dongd, Q. Ping Douj, Janice E. Drewan, Eyad Elkordao, Bassel El-Rayesap, Mark A. Feitelsonh, Dean W. Felsheru, Lynnette R. Fergusonaq, Carmela Fimognariar, Gary L. Firestoneas, Christian Frezzaat, Hiromasa Fujii au, Mark M. Fusterav, Daniele Generaliaw,ax, Alexandros G. Georgakilasay, Frank Gieseleraz, Michael Gilbertsonba, Michelle F. Greenbb, Brendan Gruebc, Gunjan Guhal, Dorota Halickabd, William G. Helferichbe, Petr Henebergbf, Patricia Hentoshbg, Matthew D. Hirscheyam,bb, Lorne J. Hofsethbh, Randall F. Holcombebi, Kanya Honokiau, Hsue-Yin Hsubj, Gloria S. Huangbk, Lasse D. Jensenbl,bm, Wen G. Jiangbn, Lee W. Jonesbo, Phillip A. Karpowiczbp, W. Nicol Keithm, Sid P. Kerkarbq, Gazala N. Khanbr, Mahin Khatamibs, Young H. Kobt, Omer Kucukd, Rob J. Kulathinalh, Nagi B. Kumarbu, Byoung S. Kwonaa,bw, Anne Lebx, Michael A. Leaby, Ho-Young Leebz, Terry Lichtorca, Liang-Tzung Lincb, Jason W. Locasalecc, Bal L. Lokeshwarcd, Valter D. Longoce, Costas A. Lyssiotis cf, Karen L. MacKenziecg, Meenakshi Malhotrach, Maria Marinoci, Maria L. Martinez-Chantarcj, Ander Matheuck, Christopher Maxwellx, Eoin McDonnellbb, Alan K. Meekercl, Mahya Mehrmohamadicm, Kapil Mehtacn, Gregory A. Michelottiam, Ramzi M. Mohammadj, Sulma I. Mohammedco, D. James Morrecp, Irfana Muqbilj, Vinayak Muralidharcq,cr, Michael P. Murphycs, Ganji Purnachandra Nagarajuap, Rita Nahtad, Elena Niccolaict, Somaira Nowsheencu, Carolina Paniscv, Francesco Pantanocw, Virginia R. Parslowaq, Graham Paweleccx, Peter L. Pedersency, Brad Poorebx, Deepak Poudyalbh, Satya Prakashch, Mark Princecz, Lizzia Raffaghelloda, Jeffrey C. Rathmellbb, W. Kimryn Rathmellg, Swapan K. Rayv, Jörg Reichrathdb, Sarallah Rezazadehdc, Domenico Ribatti dd, Luigi Ricciardiello de, R. Brooks Robeydf,dg, Francis Rodierdh,di, H.P. Vasantha Rupasinghedj, Gian Luigi Russodk, Elizabeth P. Ryandl, Abbas K. Samadidm, Isidro Sanchez-Garciadn, Andrew J. Sandersbn, Daniele Santinicw, Malancha Sarkardo, Tetsuro Sasadadp, Neeraj K. Saxenadq, Rodney E. Shackelforddr, H.M.C. Shantha Kumarabv, Dipali Sharmads, Dong M. Shind, David Sidranskydt, Markus David Siegelindu, Emanuela Signoridv, Neetu Singhdw, Sharanya Sivananddx, Daniel Sliva dy, Carl Smythedz, Carmela Spagnuolodk, Diana M. Stafforini ea, John Staggeb, Pochi R. Subbarayanec, Tabetha Sundined, Wamidh H. Talibee, Sarah K. Thompsonef, Phuoc T. Traneg, Hendrik Ungefrorenaz, Matthew G. Vander Heidencr, Vasundara Venkateswaraneh, Dass S. Vinayai, Panagiotis J. Vlachostergiosei, Zongwei Wangej, Kathryn E. Wellendx, Richard L. Whelanbv, Eddy S. Yangek, Huanjie Yangel, Xujuan Yangbe, Paul Yaswenem, Clement Yedjouen, Xin Yinav, Jiyue Zhueo, Massimo Zollos,t/titolo:Designing a broad-spectrum integrative approach for cancer prevention and treatment/doi:10.1016%2Fj.semcancer.2015.08.002/rivista:Seminars in cancer biology/anno:2015/pagina_da:S276/pagina_a:S304/intervallo_pagine:S276–S304/volume:35
بيانات النشر: Saunders Scientific Publications, Philadelphia, PA, USA , Stati Uniti d'America, 2015.
سنة النشر: 2015
مصطلحات موضوعية: Targeted therapies, Broad-spectrum, Phytochemicals, Therapeutic resistance
الوصف: Despite exciting advances in targeted therapies, high drug costs, marginal therapeutic benefits and notable toxicities are concerning aspects of today's cancer treatments. This special issue of Seminars in Cancer Biology proposes a broad-spectrum, integrative therapeutic model to complement targeted therapies. Based on extensive reviews of the cancer hallmarks, this model selects multiple high-priority targets for each hallmark, to be approached with combinations of low-toxicity, low-cost therapeutics, including phytochemicals, adapted to the well-known complexity and heterogeneity of malignancy. A global consortium of researchers has been assembled to advance this concept, which is especially relevant in an era of rapidly expanding capacity for genomic tumor analyses, alongside alarming growth in cancer morbidity and mortality in low- and middle-income nations.
اللغة: English
DOI: 10.1016/j.semcancer.2015.08.002
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=cnr_________::8cc9662a1a6f3b211af5ef286f2c8d35Test
حقوق: OPEN
رقم الانضمام: edsair.cnr...........8cc9662a1a6f3b211af5ef286f2c8d35
قاعدة البيانات: OpenAIRE
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Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => Seminars in cancer biology 35 (2015): S276–S304. doi:10.1016/j.semcancer.2015.08.002<br />info:cnr-pdr/source/autori:Keith I. Blocka,*, Charlotte Gyllenhaala, Leroy Loweb,er,**, Amedeo Amedeic, A.R.M. Ruhul Amind, Amr Amine, Katia Aquilanof, Jack Arbiserd,ep,eq, Alexandra Arreolag, Alla Arzumanyanh, S. Salman Ashrafi, Asfar S. Azmij, Fabian Benenciak, Dipita Bhaktal, Alan Bilslandm, Anupam Bishayeen, Stacy W. Blaino, Penny B. Blocka, Chandra S. Boosanip, Thomas E. Careyq, Amancio Carneror, Marianeve Carotenutos,t, Stephanie C. Caseyu, Mrinmay Chakrabartiv, Rupesh Chaturvediw, Georgia Zhuo Chend, Helen Chenx, Sophie Cheny, Yi Charlie Chenz, Beom K. Choiaa, Maria Rosa Ciriolo f, Helen M. Coleyab, Andrew R. Collins ac, Marisa Connellx, Sarah Crawfordad, Colleen S. Curranae, Charlotta Dabrosinaf, Giovanna Damiaag, Santanu Dasguptaah, Ralph J. DeBerardinisaj, William K. Deckerak, Punita Dhawanal, Anna Mae E. Diehlam, Jin-Tang Dongd, Q. Ping Douj, Janice E. Drewan, Eyad Elkordao, Bassel El-Rayesap, Mark A. Feitelsonh, Dean W. Felsheru, Lynnette R. Fergusonaq, Carmela Fimognariar, Gary L. Firestoneas, Christian Frezzaat, Hiromasa Fujii au, Mark M. Fusterav, Daniele Generaliaw,ax, Alexandros G. Georgakilasay, Frank Gieseleraz, Michael Gilbertsonba, Michelle F. Greenbb, Brendan Gruebc, Gunjan Guhal, Dorota Halickabd, William G. Helferichbe, Petr Henebergbf, Patricia Hentoshbg, Matthew D. Hirscheyam,bb, Lorne J. Hofsethbh, Randall F. Holcombebi, Kanya Honokiau, Hsue-Yin Hsubj, Gloria S. Huangbk, Lasse D. Jensenbl,bm, Wen G. Jiangbn, Lee W. Jonesbo, Phillip A. Karpowiczbp, W. Nicol Keithm, Sid P. Kerkarbq, Gazala N. Khanbr, Mahin Khatamibs, Young H. Kobt, Omer Kucukd, Rob J. Kulathinalh, Nagi B. Kumarbu, Byoung S. Kwonaa,bw, Anne Lebx, Michael A. Leaby, Ho-Young Leebz, Terry Lichtorca, Liang-Tzung Lincb, Jason W. Locasalecc, Bal L. Lokeshwarcd, Valter D. Longoce, Costas A. Lyssiotis cf, Karen L. MacKenziecg, Meenakshi Malhotrach, Maria Marinoci, Maria L. Martinez-Chantarcj, Ander Matheuck, Christopher Maxwellx, Eoin McDonnellbb, Alan K. Meekercl, Mahya Mehrmohamadicm, Kapil Mehtacn, Gregory A. Michelottiam, Ramzi M. Mohammadj, Sulma I. Mohammedco, D. James Morrecp, Irfana Muqbilj, Vinayak Muralidharcq,cr, Michael P. Murphycs, Ganji Purnachandra Nagarajuap, Rita Nahtad, Elena Niccolaict, Somaira Nowsheencu, Carolina Paniscv, Francesco Pantanocw, Virginia R. Parslowaq, Graham Paweleccx, Peter L. Pedersency, Brad Poorebx, Deepak Poudyalbh, Satya Prakashch, Mark Princecz, Lizzia Raffaghelloda, Jeffrey C. Rathmellbb, W. Kimryn Rathmellg, Swapan K. Rayv, Jörg Reichrathdb, Sarallah Rezazadehdc, Domenico Ribatti dd, Luigi Ricciardiello de, R. Brooks Robeydf,dg, Francis Rodierdh,di, H.P. Vasantha Rupasinghedj, Gian Luigi Russodk, Elizabeth P. Ryandl, Abbas K. Samadidm, Isidro Sanchez-Garciadn, Andrew J. Sandersbn, Daniele Santinicw, Malancha Sarkardo, Tetsuro Sasadadp, Neeraj K. Saxenadq, Rodney E. Shackelforddr, H.M.C. Shantha Kumarabv, Dipali Sharmads, Dong M. Shind, David Sidranskydt, Markus David Siegelindu, Emanuela Signoridv, Neetu Singhdw, Sharanya Sivananddx, Daniel Sliva dy, Carl Smythedz, Carmela Spagnuolodk, Diana M. Stafforini ea, John Staggeb, Pochi R. Subbarayanec, Tabetha Sundined, Wamidh H. Talibee, Sarah K. Thompsonef, Phuoc T. Traneg, Hendrik Ungefrorenaz, Matthew G. Vander Heidencr, Vasundara Venkateswaraneh, Dass S. Vinayai, Panagiotis J. Vlachostergiosei, Zongwei Wangej, Kathryn E. Wellendx, Richard L. Whelanbv, Eddy S. Yangek, Huanjie Yangel, Xujuan Yangbe, Paul Yaswenem, Clement Yedjouen, Xin Yinav, Jiyue Zhueo, Massimo Zollos,t/titolo:Designing a broad-spectrum integrative approach for cancer prevention and treatment/doi:10.1016%2Fj.semcancer.2015.08.002/rivista:Seminars in cancer biology/anno:2015/pagina_da:S276/pagina_a:S304/intervallo_pagine:S276–S304/volume:35 )
Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => Saunders Scientific Publications, Philadelphia, PA, USA , Stati Uniti d'America, 2015. )
Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2015 )
Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22Targeted+therapies%22">Targeted therapies</searchLink><br /><searchLink fieldCode="DE" term="%22Broad-spectrum%22">Broad-spectrum</searchLink><br /><searchLink fieldCode="DE" term="%22Phytochemicals%22">Phytochemicals</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutic+resistance%22">Therapeutic resistance</searchLink> )
Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => Despite exciting advances in targeted therapies, high drug costs, marginal therapeutic benefits and notable toxicities are concerning aspects of today's cancer treatments. This special issue of Seminars in Cancer Biology proposes a broad-spectrum, integrative therapeutic model to complement targeted therapies. Based on extensive reviews of the cancer hallmarks, this model selects multiple high-priority targets for each hallmark, to be approached with combinations of low-toxicity, low-cost therapeutics, including phytochemicals, adapted to the well-known complexity and heterogeneity of malignancy. A global consortium of researchers has been assembled to advance this concept, which is especially relevant in an era of rapidly expanding capacity for genomic tumor analyses, alongside alarming growth in cancer morbidity and mortality in low- and middle-income nations. )
Array ( [Name] => Language [Label] => Language [Group] => Lang [Data] => English )
Array ( [Name] => DOI [Label] => DOI [Group] => ID [Data] => 10.1016/j.semcancer.2015.08.002 )
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Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsair.cnr...........8cc9662a1a6f3b211af5ef286f2c8d35 )
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IllustrationInfo