دورية
An Update on Mycobacterium TuberculosisLipoproteins
| العنوان: | An Update on Mycobacterium TuberculosisLipoproteins |
|---|---|
| المؤلفون: | Bigi, María M, Forrellad, Marina A, García, Julia S, Blanco, Federico C, Vázquez, Cristina L, Bigi, Fabiana |
| المصدر: | Future Microbiology; December 2023, Vol. 18 Issue: 18 p1381-1398, 18p |
| مستخلص: | Almost 3% of the proteins of Mycobacterium tuberculosis(M. tuberculosis), the main causative agent of human tuberculosis, are lipoproteins. These lipoproteins are characteristic of the mycobacterial cell envelope and participate in many mechanisms involved in the pathogenesis of M. tuberculosis. In this review, the authors provide an updated analysis of M. tuberculosislipoproteins and categorize them according to their demonstrated or predicted functions, including transport of compounds to and from the cytoplasm, biosynthesis of the mycobacterial cell envelope, defense and resistance mechanisms, enzymatic activities and signaling pathways. In addition, this updated analysis revealed that at least 40% of M. tuberculosislipoproteins are glycosylated. |
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