دورية
Multiple sources of signal amplification within the B-cell Ras/MAPK pathway
| العنوان: | Multiple sources of signal amplification within the B-cell Ras/MAPK pathway |
|---|---|
| المؤلفون: | Mclaurin, Justin D., Weiner, Orion D. |
| المصدر: | Molecular Biology of the Cell; June 2019, Vol. 30 Issue: 13 p1610-1620, 11p |
| مستخلص: | Feedback-driven Ras activation is thought to underlie the bimodal ERK responses characteristic of activated lymphocytes. We revisit this question by imaging Ras and ERK activity biosensors in tandem. We provide evidence for digitization of ERK signaling downstream of Ras. |
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