دورية أكاديمية
Stathmin Immunoreactivity in Phaeochromocytomas and Paragangliomas: Differential Expression Between Benign and Malignant Neoplasms.
| العنوان: | Stathmin Immunoreactivity in Phaeochromocytomas and Paragangliomas: Differential Expression Between Benign and Malignant Neoplasms. |
|---|---|
| المؤلفون: | Lin, Wei-Chou, Chen, Shyh-Chyan, Chuang, Yuan-Ting, Kuo, Kuan-Lin, Huang, Kuo-How |
| المصدر: | Asian Journal of Surgery; Jan2011, Vol. 34 Issue 1, p15-22, 8p |
| مصطلحات موضوعية: | NEUROENDOCRINE tumors, GENE expression, IMMUNE response, IMMUNOHISTOCHEMISTRY, METASTASIS, WESTERN immunoblotting, REVERSE transcriptase polymerase chain reaction |
| مستخلص: | Objective: This study aimed to assess stathmin expression in benign and malignant phaeochromocytomas and paragangliomas. Methods: Tissue specimens from 37 patients with malignant phaeochromocytomas (n = 5), malignant paragangliomas (n = 3), benign phaeochromocytomas (n = 24), and benign paragangliomas (n = 5) were analysed for stathmin expression by western blotting and immunohistochemical staining with polyclonal antibodies. Malignancy was defined by metastases in nonchromaffin tissues. Results: There were higher stathmin expression levels in phaeochromocytomas compared to normal adrenal tissue, by western blotting and reverse-transcriptase polymerase chain reaction, whereas immunohistochemical staining showed stathmin immunoreactivity in the cytoplasm of tumour cells. Malignant neoplasms had significantly higher stathmin expression compared to benign neoplasms by western blotting and immunohistochemical staining. Conclusion: Malignant phaeochromocytomas and paragangliomas have significantly higher levels of stathmin expression compared to benign tumours. The potential value of stathmin in predicting malignancies requires further studies. [ABSTRACT FROM AUTHOR] |
| Copyright of Asian Journal of Surgery is the property of Excerpta Medica Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| قاعدة البيانات: | Supplemental Index |
Full Text Finder | ResultId |
1 |
|---|---|
| Header |
edo Supplemental Index 60163312 834 6 Academic Journal academicJournal 834.038208007813 |
| PLink |
https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edo&AN=60163312&custid=s6537998&authtype=sso |
| FullText |
Array
(
[Availability] => 0
)
Array ( [0] => Array ( [Url] => https://resolver.ebscohost.com/openurl?custid=s6537998&groupid=main&authtype=ip,guest&sid=EBSCO:edo&genre=article&issn=10159584&ISBN=&volume=34&issue=1&date=20110101&spage=15&pages=15-22&title=Asian Journal of Surgery&atitle=Stathmin%20Immunoreactivity%20in%20Phaeochromocytomas%20and%20Paragangliomas%3A%20Differential%20Expression%20Between%20Benign%20and%20Malignant%20Neoplasms.&id=DOI:10.1016/S1015-9584(11)60013-4 [Name] => Full Text Finder (s6537998api) [Category] => fullText [Text] => Full Text Finder [Icon] => https://imageserver.ebscohost.com/branding/images/FTF.gif [MouseOverText] => Full Text Finder ) ) |
| Items |
Array
(
[Name] => Title
[Label] => Title
[Group] => Ti
[Data] => Stathmin Immunoreactivity in Phaeochromocytomas and Paragangliomas: Differential Expression Between Benign and Malignant Neoplasms.
)
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Lin%2C+Wei-Chou%22">Lin, Wei-Chou</searchLink><br /><searchLink fieldCode="AR" term="%22Chen%2C+Shyh-Chyan%22">Chen, Shyh-Chyan</searchLink><br /><searchLink fieldCode="AR" term="%22Chuang%2C+Yuan-Ting%22">Chuang, Yuan-Ting</searchLink><br /><searchLink fieldCode="AR" term="%22Kuo%2C+Kuan-Lin%22">Kuo, Kuan-Lin</searchLink><br /><searchLink fieldCode="AR" term="%22Huang%2C+Kuo-How%22">Huang, Kuo-How</searchLink> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => Asian Journal of Surgery; Jan2011, Vol. 34 Issue 1, p15-22, 8p ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22NEUROENDOCRINE+tumors%22">NEUROENDOCRINE tumors</searchLink><br /><searchLink fieldCode="DE" term="%22GENE+expression%22">GENE expression</searchLink><br /><searchLink fieldCode="DE" term="%22IMMUNE+response%22">IMMUNE response</searchLink><br /><searchLink fieldCode="DE" term="%22IMMUNOHISTOCHEMISTRY%22">IMMUNOHISTOCHEMISTRY</searchLink><br /><searchLink fieldCode="DE" term="%22METASTASIS%22">METASTASIS</searchLink><br /><searchLink fieldCode="DE" term="%22WESTERN+immunoblotting%22">WESTERN immunoblotting</searchLink><br /><searchLink fieldCode="DE" term="%22REVERSE+transcriptase+polymerase+chain+reaction%22">REVERSE transcriptase polymerase chain reaction</searchLink> ) Array ( [Name] => Abstract [Label] => Abstract [Group] => Ab [Data] => Objective: This study aimed to assess stathmin expression in benign and malignant phaeochromocytomas and paragangliomas. Methods: Tissue specimens from 37 patients with malignant phaeochromocytomas (n = 5), malignant paragangliomas (n = 3), benign phaeochromocytomas (n = 24), and benign paragangliomas (n = 5) were analysed for stathmin expression by western blotting and immunohistochemical staining with polyclonal antibodies. Malignancy was defined by metastases in nonchromaffin tissues. Results: There were higher stathmin expression levels in phaeochromocytomas compared to normal adrenal tissue, by western blotting and reverse-transcriptase polymerase chain reaction, whereas immunohistochemical staining showed stathmin immunoreactivity in the cytoplasm of tumour cells. Malignant neoplasms had significantly higher stathmin expression compared to benign neoplasms by western blotting and immunohistochemical staining. Conclusion: Malignant phaeochromocytomas and paragangliomas have significantly higher levels of stathmin expression compared to benign tumours. The potential value of stathmin in predicting malignancies requires further studies. [ABSTRACT FROM AUTHOR] ) Array ( [Name] => Abstract [Label] => [Group] => Ab [Data] => <i>Copyright of Asian Journal of Surgery is the property of Excerpta Medica Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) ) |
| RecordInfo |
Array
(
[BibEntity] => Array
(
[Identifiers] => Array
(
[0] => Array
(
[Type] => doi
[Value] => 10.1016/S1015-9584(11)60013-4
)
)
[Languages] => Array
(
[0] => Array
(
[Code] => eng
[Text] => English
)
)
[PhysicalDescription] => Array
(
[Pagination] => Array
(
[PageCount] => 8
[StartPage] => 15
)
)
[Subjects] => Array
(
[0] => Array
(
[SubjectFull] => NEUROENDOCRINE tumors
[Type] => general
)
[1] => Array
(
[SubjectFull] => GENE expression
[Type] => general
)
[2] => Array
(
[SubjectFull] => IMMUNE response
[Type] => general
)
[3] => Array
(
[SubjectFull] => IMMUNOHISTOCHEMISTRY
[Type] => general
)
[4] => Array
(
[SubjectFull] => METASTASIS
[Type] => general
)
[5] => Array
(
[SubjectFull] => WESTERN immunoblotting
[Type] => general
)
[6] => Array
(
[SubjectFull] => REVERSE transcriptase polymerase chain reaction
[Type] => general
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Stathmin Immunoreactivity in Phaeochromocytomas and Paragangliomas: Differential Expression Between Benign and Malignant Neoplasms.
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Lin, Wei-Chou
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Chen, Shyh-Chyan
)
)
)
[2] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Chuang, Yuan-Ting
)
)
)
[3] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Kuo, Kuan-Lin
)
)
)
[4] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Huang, Kuo-How
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 01
[M] => 01
[Text] => Jan2011
[Type] => published
[Y] => 2011
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-print
[Value] => 10159584
)
)
[Numbering] => Array
(
[0] => Array
(
[Type] => volume
[Value] => 34
)
[1] => Array
(
[Type] => issue
[Value] => 1
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Asian Journal of Surgery
[Type] => main
)
)
)
)
)
)
)
|
| IllustrationInfo |