دورية أكاديمية
Early versus delayed hormonal treatment in locally advanced or asymptomatic metastatic prostatic cancer patient dilemma.
| العنوان: | Early versus delayed hormonal treatment in locally advanced or asymptomatic metastatic prostatic cancer patient dilemma. |
|---|---|
| المؤلفون: | Prezioso, Domenico, Iacono, Fabrizio, Romeo, Giuseppe, Ruffo, Antonio, Russo, Nicola, Illiano, Ester |
| المصدر: | World Journal of Urology; Jun2014, Vol. 32 Issue 3, p661-667, 7p |
| مصطلحات موضوعية: | HORMONE therapy, PROSTATE cancer patients, PROSTATE cancer treatment, TREATMENT effectiveness, EARLY medical intervention, CANCER-related mortality, DISEASE progression |
| مستخلص: | Introduction: The objective of this work is to compare the effectiveness of hormonal treatment (luteinizing hormone-releasing hormone agonists and/or antiandrogens) as an early or as a deferred intervention for patients with locally advanced prostate cancer (LAPC) and/or asymptomatic metastasis. Materials and methods: Systematic review of trials published in 1950-2007. Sources included MEDLINE and bibliographies of retrieved articles. Eligible trials included adults with a history of LAPC who are not suitable for curative local treatment of prostate cancer. We retrieved 22 articles for detailed review, of which 8 met inclusion criteria. The Veterans Administration Cooperative Urological Research Group suggested that delaying hormonal therapy did not compromise overall survival and that many of the patients died of causes other than prostate cancer. In European Organisation for Research and Treatment of Cancer (EORTC) 30846 trial, the median survival for delayed endocrine treatment was 6.1 year, and for immediate treatment 7.6 year, the HR for survival on delayed versus immediate treatment was 1.23 (95 % CI 0.88-1.71), indicating a 23 % nonsignificant trend in favour of early treatment. In EORTC 30891, the immediate androgen deprivation resulted in a modest but statistically significant increase in overall survival. The protocol SAKK 08/88 showed the lack of any major advantage of immediate compared with deferred hormonal treatment regarding quality of life or overall survival. Conclusions: The early intervention with hormonal treatment for patients with LAPC provides important reductions in all-cause mortality, prostate cancer-specific mortality, overall progression, and distant progression compared with deferring their use until standard care has failed to halt the disease. [ABSTRACT FROM AUTHOR] |
| Copyright of World Journal of Urology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| قاعدة البيانات: | Complementary Index |
| ResultId |
1 |
|---|---|
| Header |
edb Complementary Index 96151999 845 6 Academic Journal academicJournal 844.749389648438 |
| PLink |
https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edb&AN=96151999&custid=s6537998&authtype=sso |
| FullText |
Array
(
[Availability] => 0
)
|
| Items |
Array
(
[Name] => Title
[Label] => Title
[Group] => Ti
[Data] => Early versus delayed hormonal treatment in locally advanced or asymptomatic metastatic prostatic cancer patient dilemma.
)
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Prezioso%2C+Domenico%22">Prezioso, Domenico</searchLink><br /><searchLink fieldCode="AR" term="%22Iacono%2C+Fabrizio%22">Iacono, Fabrizio</searchLink><br /><searchLink fieldCode="AR" term="%22Romeo%2C+Giuseppe%22">Romeo, Giuseppe</searchLink><br /><searchLink fieldCode="AR" term="%22Ruffo%2C+Antonio%22">Ruffo, Antonio</searchLink><br /><searchLink fieldCode="AR" term="%22Russo%2C+Nicola%22">Russo, Nicola</searchLink><br /><searchLink fieldCode="AR" term="%22Illiano%2C+Ester%22">Illiano, Ester</searchLink> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => World Journal of Urology; Jun2014, Vol. 32 Issue 3, p661-667, 7p ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22HORMONE+therapy%22">HORMONE therapy</searchLink><br /><searchLink fieldCode="DE" term="%22PROSTATE+cancer+patients%22">PROSTATE cancer patients</searchLink><br /><searchLink fieldCode="DE" term="%22PROSTATE+cancer+treatment%22">PROSTATE cancer treatment</searchLink><br /><searchLink fieldCode="DE" term="%22TREATMENT+effectiveness%22">TREATMENT effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22EARLY+medical+intervention%22">EARLY medical intervention</searchLink><br /><searchLink fieldCode="DE" term="%22CANCER-related+mortality%22">CANCER-related mortality</searchLink><br /><searchLink fieldCode="DE" term="%22DISEASE+progression%22">DISEASE progression</searchLink> ) Array ( [Name] => Abstract [Label] => Abstract [Group] => Ab [Data] => Introduction: The objective of this work is to compare the effectiveness of hormonal treatment (luteinizing hormone-releasing hormone agonists and/or antiandrogens) as an early or as a deferred intervention for patients with locally advanced prostate cancer (LAPC) and/or asymptomatic metastasis. Materials and methods: Systematic review of trials published in 1950-2007. Sources included MEDLINE and bibliographies of retrieved articles. Eligible trials included adults with a history of LAPC who are not suitable for curative local treatment of prostate cancer. We retrieved 22 articles for detailed review, of which 8 met inclusion criteria. The Veterans Administration Cooperative Urological Research Group suggested that delaying hormonal therapy did not compromise overall survival and that many of the patients died of causes other than prostate cancer. In European Organisation for Research and Treatment of Cancer (EORTC) 30846 trial, the median survival for delayed endocrine treatment was 6.1 year, and for immediate treatment 7.6 year, the HR for survival on delayed versus immediate treatment was 1.23 (95 % CI 0.88-1.71), indicating a 23 % nonsignificant trend in favour of early treatment. In EORTC 30891, the immediate androgen deprivation resulted in a modest but statistically significant increase in overall survival. The protocol SAKK 08/88 showed the lack of any major advantage of immediate compared with deferred hormonal treatment regarding quality of life or overall survival. Conclusions: The early intervention with hormonal treatment for patients with LAPC provides important reductions in all-cause mortality, prostate cancer-specific mortality, overall progression, and distant progression compared with deferring their use until standard care has failed to halt the disease. [ABSTRACT FROM AUTHOR] ) Array ( [Name] => Abstract [Label] => [Group] => Ab [Data] => <i>Copyright of World Journal of Urology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) ) |
| RecordInfo |
Array
(
[BibEntity] => Array
(
[Identifiers] => Array
(
[0] => Array
(
[Type] => doi
[Value] => 10.1007/s00345-013-1144-x
)
)
[Languages] => Array
(
[0] => Array
(
[Code] => eng
[Text] => English
)
)
[PhysicalDescription] => Array
(
[Pagination] => Array
(
[PageCount] => 7
[StartPage] => 661
)
)
[Subjects] => Array
(
[0] => Array
(
[SubjectFull] => HORMONE therapy
[Type] => general
)
[1] => Array
(
[SubjectFull] => PROSTATE cancer patients
[Type] => general
)
[2] => Array
(
[SubjectFull] => PROSTATE cancer treatment
[Type] => general
)
[3] => Array
(
[SubjectFull] => TREATMENT effectiveness
[Type] => general
)
[4] => Array
(
[SubjectFull] => EARLY medical intervention
[Type] => general
)
[5] => Array
(
[SubjectFull] => CANCER-related mortality
[Type] => general
)
[6] => Array
(
[SubjectFull] => DISEASE progression
[Type] => general
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Early versus delayed hormonal treatment in locally advanced or asymptomatic metastatic prostatic cancer patient dilemma.
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Prezioso, Domenico
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Iacono, Fabrizio
)
)
)
[2] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Romeo, Giuseppe
)
)
)
[3] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Ruffo, Antonio
)
)
)
[4] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Russo, Nicola
)
)
)
[5] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Illiano, Ester
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 01
[M] => 06
[Text] => Jun2014
[Type] => published
[Y] => 2014
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-print
[Value] => 07244983
)
)
[Numbering] => Array
(
[0] => Array
(
[Type] => volume
[Value] => 32
)
[1] => Array
(
[Type] => issue
[Value] => 3
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => World Journal of Urology
[Type] => main
)
)
)
)
)
)
)
|
| IllustrationInfo |