دورية أكاديمية
Concurrent versus Sequential Sorafenib Therapy in Combination with Radiation for Hepatocellular Carcinoma.
العنوان: | Concurrent versus Sequential Sorafenib Therapy in Combination with Radiation for Hepatocellular Carcinoma. |
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المؤلفون: | Wild, Aaron T., Gandhi, Nishant, Chettiar, Sivarajan T., Aziz, Khaled, Gajula, Rajendra P., Williams, Russell D., Kumar, Rachit, Taparra, Kekoa, Zeng, Jing, Cades, Jessica A., Velarde, Esteban, Menon, Siddharth, Geschwind, Jean F., Cosgrove, David, Pawlik, Timothy M., Maitra, Anirban, Wong, John, Hales, Russell K., Torbenson, Michael S., Herman, Joseph M. |
المصدر: | PLoS ONE; Jun2013, Vol. 8 Issue 6, p1-13, 13p |
مصطلحات موضوعية: | LIVER cancer, CANCER radiotherapy, RADIOBIOLOGY, GASTROENTEROLOGY, HEPATOLOGY, ONCOLOGY, XENOGRAFTS |
مستخلص: | Sorafenib (SOR) is the only systemic agent known to improve survival for hepatocellular carcinoma (HCC). However, SOR prolongs survival by less than 3 months and does not alter symptomatic progression. To improve outcomes, several phase I-II trials are currently examining SOR with radiation (RT) for HCC utilizing heterogeneous concurrent and sequential treatment regimens. Our study provides preclinical data characterizing the effects of concurrent versus sequential RT-SOR on HCC cells both in vitro and in vivo. Concurrent and sequential RT-SOR regimens were tested for efficacy among 4 HCC cell lines in vitro by assessment of clonogenic survival, apoptosis, cell cycle distribution, and γ-H2AX foci formation. Results were confirmed in vivo by evaluating tumor growth delay and performing immunofluorescence staining in a hind-flank xenograft model. In vitro, concurrent RT-SOR produced radioprotection in 3 of 4 cell lines, whereas sequential RT-SOR produced decreased colony formation among all 4. Sequential RT-SOR increased apoptosis compared to RT alone, while concurrent RT-SOR did not. Sorafenib induced reassortment into less radiosensitive phases of the cell cycle through G |
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قاعدة البيانات: | Complementary Index |