دورية أكاديمية
Low Levels of Mannan-Binding Lectin or Ficolins Are Not Associated with an Increased Risk of Cytomegalovirus Disease in HIV-Infected Patients.
العنوان: | Low Levels of Mannan-Binding Lectin or Ficolins Are Not Associated with an Increased Risk of Cytomegalovirus Disease in HIV-Infected Patients. |
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المؤلفون: | Egli, Adrian, Schäfer, Juliane, Osthoff, Michael, Thiel, Steffen, Mikkelsen, Christina, Rauch, Andri, Hirsch, Hans H., Bucher, Heiner C., Young, James, Jensenius, Jens C., Battegay, Manuel, Trendelenburg, Marten |
المصدر: | PLoS ONE; Jan2013, Vol. 8 Issue 1, Special section p1-9, 9p |
مصطلحات موضوعية: | HIV-positive persons, CYTOMEGALOVIRUSES, LECTINS, ANTIRETROVIRAL agents, HIV infections, ANTI-infective agents |
مستخلص: | Background: In HIV-infected patients, prediction of Cytomegalovirus (CMV) disease remains difficult. A protective role of mannan-binding lectin (MBL) and ficolins against CMV disease has been reported after transplantation, but the impact in HIV-infected patients is unclear. Methods:In a case-control study nested within the Swiss HIV Cohort Study, we investigated associations between plasma levels of MBL/ficolins and CMV disease. We compared HIV-infected patients with CMV disease (cases) to CMV-seropositive patients without CMV disease (controls) matched for CD4 T-cells, sampling time, and use of combination antiretroviral therapy. MBL and M-ficolin, L-ficolin, and H-ficolin were quantified using ELISA. Results:We analysed 105 cases and 105 matched controls. CMV disease was neither associated with MBL (odds ratio [OR] 1.03 per log |
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قاعدة البيانات: | Complementary Index |