دورية أكاديمية
Common variants at 6p21.1 are associated with large artery atherosclerotic stroke.
العنوان: | Common variants at 6p21.1 are associated with large artery atherosclerotic stroke. |
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المؤلفون: | Holliday, Elizabeth G, Maguire, Jane M, Evans, Tiffany-Jane, Koblar, Simon A, Jannes, Jim, Sturm, Jonathan W, Hankey, Graeme J, Baker, Ross, Golledge, Jonathan, Parsons, Mark W, Malik, Rainer, McEvoy, Mark, Biros, Erik, Lewis, Martin D, Lincz, Lisa F, Peel, Roseanne, Oldmeadow, Christopher, Smith, Wayne, Moscato, Pablo, Barlera, Simona |
المصدر: | Nature Genetics; Oct2012, Vol. 44 Issue 10, p1147-1151, 5p, 1 Diagram, 2 Charts, 2 Graphs |
مصطلحات موضوعية: | HUMAN genetic variation, ATHEROSCLEROSIS, STROKE risk factors, ETIOLOGY of diseases, DISEASE susceptibility, CHROMOSOMES |
مستخلص: | Genome-wide association studies (GWAS) have not consistently detected replicable genetic risk factors for ischemic stroke, potentially due to etiological heterogeneity of this trait. We performed GWAS of ischemic stroke and a major ischemic stroke subtype (large artery atherosclerosis, LAA) using 1,162 ischemic stroke cases (including 421 LAA cases) and 1,244 population controls from Australia. Evidence for a genetic influence on ischemic stroke risk was detected, but this influence was higher and more significant for the LAA subtype. We identified a new LAA susceptibility locus on chromosome 6p21.1 (rs556621: odds ratio (OR) = 1.62, P = 3.9 × 10?8) and replicated this association in 1,715 LAA cases and 52,695 population controls from 10 independent population cohorts (meta-analysis replication OR = 1.15, P = 3.9 × 10?4; discovery and replication combined OR = 1.21, P = 4.7 × 10?8). This study identifies a genetic risk locus for LAA and shows how analyzing etiological subtypes may better identify genetic risk alleles for ischemic stroke. [ABSTRACT FROM AUTHOR] |
Copyright of Nature Genetics is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
قاعدة البيانات: | Complementary Index |
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