دورية أكاديمية
Liver cancer immunoassay with magnetic nanoparticles and MgO-based magnetic tunnel junction sensors.
| العنوان: | Liver cancer immunoassay with magnetic nanoparticles and MgO-based magnetic tunnel junction sensors. |
|---|---|
| المؤلفون: | Lei, Z. Q., Li, L., Li, G. J., Leung, C. W., Shi, J., Wong, C. M., Lo, K. C., Chan, W. K., Mak, C. S. K., Chan, S. B., Chan, N. M. M., Leung, C. H., Lai, P. T., Pong, P. W. T. |
| المصدر: | Journal of Applied Physics; Apr2012, Vol. 111 Issue 7, p07E505-07E505-3, 1p |
| مصطلحات موضوعية: | NANOPARTICLES, MANGANESE oxides, LIVER cancer, IMMUNOASSAY, ALPHA fetoproteins, QUANTUM tunneling, DETECTORS |
| مستخلص: | We have demonstrated the detection of alpha-fetoprotein (AFP) labeled with magnetic nanoparticles (MNPs) using MgO-based magnetic tunnel junction (MTJ) sensors. AFP is an important hepatic tumor biomarker and the detection of AFP has significant applications for clinical diagnostics and immunoassay for early-stage liver cancer indications. In this work, MgO-based MTJ sensors and 20-nm iron-oxide magnetic nanoparticles (MNPs) were used for detecting AFP antigens by a sandwich-assay configuration. The MTJ sensors with a sensing area of 4 × 2 μm2 possess tunneling magnetoresistance (TMR) of 122% and sensitivity of 0.95%/Oe at room temperature. The target AFP antigens of three concentrations were successfully detected, and the experimental data indicate that the resistance variations of the MTJ sensor increased with the AFP concentration ratios proportionally. These results demonstrate that MgO-based MTJ sensors together with MNPs are a promising biosensing platform for liver cancer immunoassay. [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Applied Physics is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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