دورية أكاديمية
Recurrence and variability of germline EPCAM deletions in Lynch syndrome.
| العنوان: | Recurrence and variability of germline EPCAM deletions in Lynch syndrome. |
|---|---|
| المؤلفون: | Kuiper, Roland P., Vissers, Lisenka E. L. M., Venkatachalam, Ramprasath, Bodmer, Danielle, Hoenselaar, Eveline, Goossens, Monique, Haufe, Aline, Kamping, Eveline, Niessen, Renée C., Hogervorst, Frans B. L., Gille, Johan J. P., Redeker, Bert, Tops, Carli M. J., van Gijn, Marielle E., van den Ouweland, Ans M.W., Rahner, Nils, Steinke, Verena, Kahl, Philip, Holinski-Feder, Elke, Morak, Monika |
| المصدر: | Human Mutation; Apr2011, Vol. 32 Issue 4, p407-414, 8p, 2 Diagrams, 2 Charts |
| مصطلحات موضوعية: | GENES, LYNCH syndrome II, EPITHELIAL cells |
| مصطلحات جغرافية: | NETHERLANDS, UNITED States, GERMANY |
| مستخلص: | The article discusses a study on the role of 3' end EPCAM gene deletions in Lynch syndrome. The study involved 45 independent Lynch syndrome families from several countries including the Netherlands, Germany and the U.S. EPCAM deletions were identified in 27 families. The study found that methylation of the MSH2 gene promoter occurred in epithelial tissues of all carriers of EPCAM deletion. Alu-repeat mediated recombination events seemed to be the origin of all deletions based on analysis. |
| قاعدة البيانات: | Complementary Index |
Full Text Finder | ResultId |
1 |
|---|---|
| Header |
edb Complementary Index 59319954 834 6 Academic Journal academicJournal 834.046752929688 |
| PLink |
https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edb&AN=59319954&custid=s6537998&authtype=sso |
| FullText |
Array
(
[Availability] => 0
)
Array ( [0] => Array ( [Url] => https://resolver.ebscohost.com/openurl?custid=s6537998&groupid=main&authtype=ip,guest&sid=EBSCO:edb&genre=article&issn=10597794&ISBN=&volume=32&issue=4&date=20110401&spage=407&pages=407-414&title=Human Mutation&atitle=Recurrence%20and%20variability%20of%20germline%20EPCAM%20deletions%20in%20Lynch%20syndrome.&id=DOI:10.1002/humu.21446 [Name] => Full Text Finder (s6537998api) [Category] => fullText [Text] => Full Text Finder [Icon] => https://imageserver.ebscohost.com/branding/images/FTF.gif [MouseOverText] => Full Text Finder ) ) |
| Items |
Array
(
[Name] => Title
[Label] => Title
[Group] => Ti
[Data] => Recurrence and variability of germline EPCAM deletions in Lynch syndrome.
)
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Kuiper%2C+Roland+P%2E%22">Kuiper, Roland P.</searchLink><br /><searchLink fieldCode="AR" term="%22Vissers%2C+Lisenka+E%2E+L%2E+M%2E%22">Vissers, Lisenka E. L. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Venkatachalam%2C+Ramprasath%22">Venkatachalam, Ramprasath</searchLink><br /><searchLink fieldCode="AR" term="%22Bodmer%2C+Danielle%22">Bodmer, Danielle</searchLink><br /><searchLink fieldCode="AR" term="%22Hoenselaar%2C+Eveline%22">Hoenselaar, Eveline</searchLink><br /><searchLink fieldCode="AR" term="%22Goossens%2C+Monique%22">Goossens, Monique</searchLink><br /><searchLink fieldCode="AR" term="%22Haufe%2C+Aline%22">Haufe, Aline</searchLink><br /><searchLink fieldCode="AR" term="%22Kamping%2C+Eveline%22">Kamping, Eveline</searchLink><br /><searchLink fieldCode="AR" term="%22Niessen%2C+Renée+C%2E%22">Niessen, Renée C.</searchLink><br /><searchLink fieldCode="AR" term="%22Hogervorst%2C+Frans+B%2E+L%2E%22">Hogervorst, Frans B. L.</searchLink><br /><searchLink fieldCode="AR" term="%22Gille%2C+Johan+J%2E+P%2E%22">Gille, Johan J. P.</searchLink><br /><searchLink fieldCode="AR" term="%22Redeker%2C+Bert%22">Redeker, Bert</searchLink><br /><searchLink fieldCode="AR" term="%22Tops%2C+Carli+M%2E+J%2E%22">Tops, Carli M. J.</searchLink><br /><searchLink fieldCode="AR" term="%22van+Gijn%2C+Marielle+E%2E%22">van Gijn, Marielle E.</searchLink><br /><searchLink fieldCode="AR" term="%22van+den+Ouweland%2C+Ans+M%2EW%2E%22">van den Ouweland, Ans M.W.</searchLink><br /><searchLink fieldCode="AR" term="%22Rahner%2C+Nils%22">Rahner, Nils</searchLink><br /><searchLink fieldCode="AR" term="%22Steinke%2C+Verena%22">Steinke, Verena</searchLink><br /><searchLink fieldCode="AR" term="%22Kahl%2C+Philip%22">Kahl, Philip</searchLink><br /><searchLink fieldCode="AR" term="%22Holinski-Feder%2C+Elke%22">Holinski-Feder, Elke</searchLink><br /><searchLink fieldCode="AR" term="%22Morak%2C+Monika%22">Morak, Monika</searchLink> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => Human Mutation; Apr2011, Vol. 32 Issue 4, p407-414, 8p, 2 Diagrams, 2 Charts ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22GENES%22">GENES</searchLink><br /><searchLink fieldCode="DE" term="%22LYNCH+syndrome+II%22">LYNCH syndrome II</searchLink><br /><searchLink fieldCode="DE" term="%22EPITHELIAL+cells%22">EPITHELIAL cells</searchLink> ) Array ( [Name] => SubjectGeographic [Label] => Geographic Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22NETHERLANDS%22">NETHERLANDS</searchLink><br /><searchLink fieldCode="DE" term="%22UNITED+States%22">UNITED States</searchLink><br /><searchLink fieldCode="DE" term="%22GERMANY%22">GERMANY</searchLink> ) Array ( [Name] => Abstract [Label] => Abstract [Group] => Ab [Data] => The article discusses a study on the role of 3' end EPCAM gene deletions in Lynch syndrome. The study involved 45 independent Lynch syndrome families from several countries including the Netherlands, Germany and the U.S. EPCAM deletions were identified in 27 families. The study found that methylation of the MSH2 gene promoter occurred in epithelial tissues of all carriers of EPCAM deletion. Alu-repeat mediated recombination events seemed to be the origin of all deletions based on analysis. ) |
| RecordInfo |
Array
(
[BibEntity] => Array
(
[Identifiers] => Array
(
[0] => Array
(
[Type] => doi
[Value] => 10.1002/humu.21446
)
)
[Languages] => Array
(
[0] => Array
(
[Code] => eng
[Text] => English
)
)
[PhysicalDescription] => Array
(
[Pagination] => Array
(
[PageCount] => 8
[StartPage] => 407
)
)
[Subjects] => Array
(
[0] => Array
(
[SubjectFull] => NETHERLANDS
[Type] => general
)
[1] => Array
(
[SubjectFull] => UNITED States
[Type] => general
)
[2] => Array
(
[SubjectFull] => GERMANY
[Type] => general
)
[3] => Array
(
[SubjectFull] => GENES
[Type] => general
)
[4] => Array
(
[SubjectFull] => LYNCH syndrome II
[Type] => general
)
[5] => Array
(
[SubjectFull] => EPITHELIAL cells
[Type] => general
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Recurrence and variability of germline EPCAM deletions in Lynch syndrome.
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Kuiper, Roland P.
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Vissers, Lisenka E. L. M.
)
)
)
[2] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Venkatachalam, Ramprasath
)
)
)
[3] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Bodmer, Danielle
)
)
)
[4] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Hoenselaar, Eveline
)
)
)
[5] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Goossens, Monique
)
)
)
[6] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Haufe, Aline
)
)
)
[7] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Kamping, Eveline
)
)
)
[8] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Niessen, Renée C.
)
)
)
[9] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Hogervorst, Frans B. L.
)
)
)
[10] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Gille, Johan J. P.
)
)
)
[11] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Redeker, Bert
)
)
)
[12] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Tops, Carli M. J.
)
)
)
[13] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => van Gijn, Marielle E.
)
)
)
[14] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => van den Ouweland, Ans M.W.
)
)
)
[15] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Rahner, Nils
)
)
)
[16] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Steinke, Verena
)
)
)
[17] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Kahl, Philip
)
)
)
[18] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Holinski-Feder, Elke
)
)
)
[19] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Morak, Monika
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 01
[M] => 04
[Text] => Apr2011
[Type] => published
[Y] => 2011
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-print
[Value] => 10597794
)
)
[Numbering] => Array
(
[0] => Array
(
[Type] => volume
[Value] => 32
)
[1] => Array
(
[Type] => issue
[Value] => 4
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Human Mutation
[Type] => main
)
)
)
)
)
)
)
|
| IllustrationInfo |