دورية أكاديمية
Characterization of highly frequent epitope-specific CD45RA+/CCR7+/- T lymphocyte responses against p53-binding domains of the human polyomavirus BK large tumor antigen in HLA-A*0201+ BKV-seropositive donors.
العنوان: | Characterization of highly frequent epitope-specific CD45RA+/CCR7+/- T lymphocyte responses against p53-binding domains of the human polyomavirus BK large tumor antigen in HLA-A*0201+ BKV-seropositive donors. |
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المؤلفون: | Provenzano, Maurizio, Bracci, Laura, Wyler, Stephen, Hudolin, Tvrtko, Sais, Giovanni, Gosert, Rainer, Zajac, Paul, Palu, Giorgio, Heberer, Michael, Hirsch, Hans H., Spagnoli, Giulio C. |
المصدر: | Journal of Translational Medicine; 2006, Vol. 4, p1-15, 15p, 4 Charts, 7 Graphs |
مصطلحات موضوعية: | POLYOMAVIRUSES, VIRAL replication, TUMOR antigens, P53 protein, GENE expression, IMMUNOLOGICAL tolerance |
مستخلص: | Human polyomavirus BK (BKV) has been implicated in oncogenic transformation. Its ability to replicate is determined by the binding of its large tumor antigen (LTag) to products of tumorsuppressor genes regulating cell cycle, as specifically p53. We investigated CD8+ T immune responses to BKV LTag portions involved in p53 binding in HLA-A*0201+ BKV LTag experienced individuals. Peptides selected from either p53-binding region (LTag |
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قاعدة البيانات: | Complementary Index |