دورية أكاديمية
Cyclic arginine-glycine-aspartic acid peptide inhibits macrophage infiltration of the kidney and carotid artery lesions in apo-E-deficient mice.
| العنوان: | Cyclic arginine-glycine-aspartic acid peptide inhibits macrophage infiltration of the kidney and carotid artery lesions in apo-E-deficient mice. |
|---|---|
| المؤلفون: | Elitok, Saban, Brodsky, Sergey V., Patschan, Daniel, Orlova, Tatyana, Lerea, Kenneth M., Chander, Praveen, Goligorsky, Michael S. |
| المصدر: | American Journal of Physiology: Renal Physiology; Jan2006, Vol. 290, pF159-F166, 8p, 16 Graphs |
| مصطلحات موضوعية: | PEPTIDES, MACROPHAGES, KIDNEYS, APOLIPOPROTEIN E, AMINO acids, CAROTID artery |
| مستخلص: | Interactions of leukocytes with the vascular endothelium culminating in their diapedesis represent not only a crucial event in immune surveillance and defense but are also critically involved in the pathogenesis of many inflammatory diseases, including atherosclerosis. Our previous in vitro studies using atomic force microscopy measurement of monocyte-endothelial cell interaction have demonstrated that a cyclic arginine-glycine-aspartic acid peptide (cRGD) inhibited their adhesion through very late antigen (α |
| Copyright of American Journal of Physiology: Renal Physiology is the property of American Physiological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| قاعدة البيانات: | Complementary Index |
Full Text Finder | ResultId |
1 |
|---|---|
| Header |
edb Complementary Index 19346053 833 6 Academic Journal academicJournal 832.6142578125 |
| PLink |
https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edb&AN=19346053&custid=s6537998&authtype=sso |
| FullText |
Array
(
[Availability] => 0
)
Array ( [0] => Array ( [Url] => https://resolver.ebscohost.com/openurl?custid=s6537998&groupid=main&authtype=ip,guest&sid=EBSCO:edb&genre=article&issn=1931857X&ISBN=&volume=290&issue=&date=20060101&spage=F159&pages=&title=American Journal of Physiology: Renal Physiology&atitle=Cyclic%20arginine-glycine-aspartic%20acid%20peptide%20inhibits%20macrophage%20infiltration%20of%20the%20kidney%20and%20carotid%20artery%20lesions%20in%20apo-E-deficient%20mice.&id=DOI:10.1152/ajprenal.00227.2005 [Name] => Full Text Finder (s6537998api) [Category] => fullText [Text] => Full Text Finder [Icon] => https://imageserver.ebscohost.com/branding/images/FTF.gif [MouseOverText] => Full Text Finder ) ) |
| Items |
Array
(
[Name] => Title
[Label] => Title
[Group] => Ti
[Data] => Cyclic arginine-glycine-aspartic acid peptide inhibits macrophage infiltration of the kidney and carotid artery lesions in apo-E-deficient mice.
)
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Elitok%2C+Saban%22">Elitok, Saban</searchLink><br /><searchLink fieldCode="AR" term="%22Brodsky%2C+Sergey+V%2E%22">Brodsky, Sergey V.</searchLink><br /><searchLink fieldCode="AR" term="%22Patschan%2C+Daniel%22">Patschan, Daniel</searchLink><br /><searchLink fieldCode="AR" term="%22Orlova%2C+Tatyana%22">Orlova, Tatyana</searchLink><br /><searchLink fieldCode="AR" term="%22Lerea%2C+Kenneth+M%2E%22">Lerea, Kenneth M.</searchLink><br /><searchLink fieldCode="AR" term="%22Chander%2C+Praveen%22">Chander, Praveen</searchLink><br /><searchLink fieldCode="AR" term="%22Goligorsky%2C+Michael+S%2E%22">Goligorsky, Michael S.</searchLink> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => American Journal of Physiology: Renal Physiology; Jan2006, Vol. 290, pF159-F166, 8p, 16 Graphs ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22PEPTIDES%22">PEPTIDES</searchLink><br /><searchLink fieldCode="DE" term="%22MACROPHAGES%22">MACROPHAGES</searchLink><br /><searchLink fieldCode="DE" term="%22KIDNEYS%22">KIDNEYS</searchLink><br /><searchLink fieldCode="DE" term="%22APOLIPOPROTEIN+E%22">APOLIPOPROTEIN E</searchLink><br /><searchLink fieldCode="DE" term="%22AMINO+acids%22">AMINO acids</searchLink><br /><searchLink fieldCode="DE" term="%22CAROTID+artery%22">CAROTID artery</searchLink> ) Array ( [Name] => Abstract [Label] => Abstract [Group] => Ab [Data] => Interactions of leukocytes with the vascular endothelium culminating in their diapedesis represent not only a crucial event in immune surveillance and defense but are also critically involved in the pathogenesis of many inflammatory diseases, including atherosclerosis. Our previous in vitro studies using atomic force microscopy measurement of monocyte-endothelial cell interaction have demonstrated that a cyclic arginine-glycine-aspartic acid peptide (cRGD) inhibited their adhesion through very late antigen (α<subscript>4</subscript>β<subscript>1</subscript>-integrin; VLA4)-vascular cell adhesion molecule-i by 60% with the IC<subscript>50</subscript> = 100 nM. To elucidate the potential efficacy of this peptide in vivo in preventing atherogenesis, experiments were performed in apolipoprotein E (ApoE)-deficient (-/-) mice fed a Western diet and receiving chronic treatment with cRGD peptide for 2-4 wk. In addition, some animals were subjected to a temporary carotid artery ligation while receiving the above treatment. Formation of fatty streaks and infiltration of the vascular wall with macrophages were not affected by cRGD treatment. Infiltration of the carotid artery postligation was significantly reduced in the cRGD-treated animals, as was the lipid accumulation. Furthermore, cRGD-treated ApoE<superscript>-/-</superscript> mice exhibited significantly lesser macrophage infiltration and lipid accumulation in the kidneys, the site of the highest expression of VLA4, These data demonstrated that cRGD peptide is a potent inhibitor of monocyte/macrophage infiltration of the injured macrovasculature and of the renal microvasculature, where it results in the attenuation of lipid accumulation. Formation of fatty streaks in the aortic root was not inhibitable by this treatment. [ABSTRACT FROM AUTHOR] ) Array ( [Name] => Abstract [Label] => [Group] => Ab [Data] => <i>Copyright of American Journal of Physiology: Renal Physiology is the property of American Physiological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) ) |
| RecordInfo |
Array
(
[BibEntity] => Array
(
[Identifiers] => Array
(
[0] => Array
(
[Type] => doi
[Value] => 10.1152/ajprenal.00227.2005
)
)
[Languages] => Array
(
[0] => Array
(
[Code] => eng
[Text] => English
)
)
[PhysicalDescription] => Array
(
[Pagination] => Array
(
[PageCount] => 8
[StartPage] => F159
)
)
[Subjects] => Array
(
[0] => Array
(
[SubjectFull] => PEPTIDES
[Type] => general
)
[1] => Array
(
[SubjectFull] => MACROPHAGES
[Type] => general
)
[2] => Array
(
[SubjectFull] => KIDNEYS
[Type] => general
)
[3] => Array
(
[SubjectFull] => APOLIPOPROTEIN E
[Type] => general
)
[4] => Array
(
[SubjectFull] => AMINO acids
[Type] => general
)
[5] => Array
(
[SubjectFull] => CAROTID artery
[Type] => general
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Cyclic arginine-glycine-aspartic acid peptide inhibits macrophage infiltration of the kidney and carotid artery lesions in apo-E-deficient mice.
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Elitok, Saban
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Brodsky, Sergey V.
)
)
)
[2] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Patschan, Daniel
)
)
)
[3] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Orlova, Tatyana
)
)
)
[4] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Lerea, Kenneth M.
)
)
)
[5] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Chander, Praveen
)
)
)
[6] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Goligorsky, Michael S.
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 01
[M] => 01
[Text] => Jan2006
[Type] => published
[Y] => 2006
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-print
[Value] => 1931857X
)
)
[Numbering] => Array
(
[0] => Array
(
[Type] => volume
[Value] => 290
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => American Journal of Physiology: Renal Physiology
[Type] => main
)
)
)
)
)
)
)
|
| IllustrationInfo |