دورية أكاديمية
Can We Predict Skeletal Lesion on Bone Scan Based on Quantitative PSMA PET/CT Features?
العنوان: | Can We Predict Skeletal Lesion on Bone Scan Based on Quantitative PSMA PET/CT Features? |
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المؤلفون: | Laudicella, Riccardo, Bauckneht, Matteo, Maurer, Alexander, Heimer, Jakob, Gennari, Antonio G., Di Raimondo, Tania, Paone, Gaetano, Cuzzocrea, Marco, Messerli, Michael, Eberli, Daniel, Burger, Irene A. |
المصدر: | Cancers; Nov2023, Vol. 15 Issue 22, p5471, 13p |
مصطلحات موضوعية: | OSTEORADIOGRAPHY, SKELETON radiography, STATISTICAL models, PROSTATE-specific antigen, PREDICTION models, RESEARCH funding, COMPUTED tomography, PROSTATE tumors, POSITRON emission tomography, DESCRIPTIVE statistics, METASTASIS, BONE metastasis, STATISTICS, PROSTATE-specific membrane antigen, TUMOR classification, RADIONUCLIDE imaging, EVALUATION |
مستخلص: | Simple Summary: Treating patients for metastatic prostate cancer based on the information of PSMA-PET bears the risk to "under- or overtreat" patients, given that many lesions seen only on PSMA-PET but not on conventional imaging (CI) could alter their management. It is not possible to predict the disease status using CI with PSMA-PET/CT, because bone lesions can be positive on bone scintigraphy (BS), without evidence of the disease on CT. Some authors suggested using clinical parameters to predict BS results, but this does not reach enough accuracy to adjust the therapy. If an algorithm based on PSMA-PET/CT data were able to predict if lesions are visible on BS, this might be a possible way to adjust patient management based on CI-based guidelines in light of PSMA-PET/CT. Therefore, we aimed to develop a model to predict the visibility of bone lesions on BS based on PSMA-PET/CT data. Objective: The increasing use of PSMA-PET/CT for restaging prostate cancer (PCa) leads to a patient shift from a non-metastatic situation based on conventional imaging (CI) to a metastatic situation. Since established therapeutic pathways have been designed according to CI, it is unclear how this should be translated to the PSMA-PET/CT results. This study aimed to investigate whether PSMA-PET/CT and clinical parameters could predict the visibility of PSMA-positive lesions on a bone scan (BS). Methods: In four different centers, all PCa patients with BS and PSMA-PET/CT within 6 months without any change in therapy or significant disease progression were retrospectively selected. Up to 10 non-confluent clear bone metastases were selected per PSMA-PET/CT and SUV |
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قاعدة البيانات: | Complementary Index |
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