دورية أكاديمية
Activation of Intra-nodose Ganglion P2X7 Receptors Elicit Increases in Neuronal Activity.
العنوان: | Activation of Intra-nodose Ganglion P2X7 Receptors Elicit Increases in Neuronal Activity. |
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المؤلفون: | Alcayaga, Julio, Vera, Jorge, Reyna-Jeldes, Mauricio, Covarrubias, Alejandra A., Coddou, Claudio, Díaz-Jara, Esteban, Del Rio, Rodrigo, Retamal, Mauricio A. |
المصدر: | Cellular & Molecular Neurobiology; Aug2023, Vol. 43 Issue 6, p2801-2813, 13p |
مصطلحات موضوعية: | PURINERGIC receptors, SENSORY ganglia, GANGLIA, GLUTAMATE receptors, SENSORY neurons, SATELLITE cells, VAGUS nerve |
مستخلص: | Vagus nerve innervates several organs including the heart, stomach, and pancreas among others. Somas of sensory neurons that project through the vagal nerve are located in the nodose ganglion. The presence of purinergic receptors has been reported in neurons and satellite glial cells in several sensory ganglia. In the nodose ganglion, calcium depletion-induced increases in neuron activity can be partly reversed by P2X7 blockers applied directly into the ganglion. The later suggest a possible role of P2X7 receptors in the modulation of neuronal activity within this sensory ganglion. We aimed to characterize the response to P2X7 activation in nodose ganglion neurons under physiological conditions. Using an ex vivo preparation for electrophysiological recordings of the neural discharges of nodose ganglion neurons, we found that treatments with ATP induce transient neuronal activity increases. Also, we found a concentration-dependent increase in neural activity in response to Bz-ATP (ED |
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قاعدة البيانات: | Complementary Index |
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