دورية أكاديمية
Crystal structure of a hypothetical protein from Giardia lamblia.
| العنوان: | Crystal structure of a hypothetical protein from Giardia lamblia. |
|---|---|
| المؤلفون: | Beard, Dylan K., Bristol, Seonna, Cosby, Kayla, Davis, Amber, Manning, Courtney, Perry, Lionel, Snapp, Lauren, Toy, Arian, Wheeler, Kayla, Young, Jeremy, Staker, Bart, Arakaki, Tracy L., Abendroth, Jan, Subrahamanian, Sandhya, Edwards, Thomas E., Myler, Peter J., Asojo, Oluwatoyin A. |
| المصدر: | Acta Crystallographica: Section F, Structural Biology Communications; Feb2022, Vol. 78 Issue 2, p59-65, 7p |
| مصطلحات موضوعية: | GIARDIA lamblia, PROTEIN structure, CRYSTAL structure, SMALL molecules, GIARDIASIS, COMMUNICABLE diseases |
| الشركة/الكيان: | HAMPTON University (Va.) |
| مستخلص: | Giardiasis is the most prevalent diarrheal disease globally and affects humans and animals. It is a significant problem in developing countries, the number one cause of travelers' diarrhea and affects children and immunocompromised individuals, especially HIV‐infected individuals. Giardiasis is treated with antibiotics (tinidazole and metronidazole) that are also used for other infections such as trichomoniasis. The ongoing search for new therapeutics for giardiasis includes characterizing the structure and function of proteins from the causative protozoan Giardia lamblia. These proteins include hypothetical proteins that share 30% sequence identity or less with proteins of known structure. Here, the atomic resolution structure of a 15.6 kDa protein was determined by molecular replacement. The structure has the two‐layer αβ‐sandwich topology observed in the prototypical endoribonucleases L‐PSPs (liver perchloric acid‐soluble proteins) with conserved allosteric active sites containing small molecules from the crystallization solution. This article is an educational collaboration between Hampton University and the Seattle Structural Genomics Center for Infectious Disease. [ABSTRACT FROM AUTHOR] |
| Copyright of Acta Crystallographica: Section F, Structural Biology Communications is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| قاعدة البيانات: | Complementary Index |
Full Text Finder | ResultId |
1 |
|---|---|
| Header |
edb Complementary Index 155005371 957 6 Academic Journal academicJournal 957.252563476563 |
| PLink |
https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edb&AN=155005371&custid=s6537998&authtype=sso |
| FullText |
Array
(
[Availability] => 0
)
Array ( [0] => Array ( [Url] => https://resolver.ebscohost.com/openurl?custid=s6537998&groupid=main&authtype=ip,guest&sid=EBSCO:edb&genre=article&issn=2053230X&ISBN=&volume=78&issue=2&date=20220201&spage=59&pages=59-65&title=Acta Crystallographica: Section F, Structural Biology Communications&atitle=Crystal%20structure%20of%20a%20hypothetical%20protein%20from%20Giardia%20lamblia.&id=DOI:10.1107/S2053230X21013595 [Name] => Full Text Finder (s6537998api) [Category] => fullText [Text] => Full Text Finder [Icon] => https://imageserver.ebscohost.com/branding/images/FTF.gif [MouseOverText] => Full Text Finder ) ) |
| Items |
Array
(
[Name] => Title
[Label] => Title
[Group] => Ti
[Data] => Crystal structure of a hypothetical protein from Giardia lamblia.
)
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Beard%2C+Dylan+K%2E%22">Beard, Dylan K.</searchLink><br /><searchLink fieldCode="AR" term="%22Bristol%2C+Seonna%22">Bristol, Seonna</searchLink><br /><searchLink fieldCode="AR" term="%22Cosby%2C+Kayla%22">Cosby, Kayla</searchLink><br /><searchLink fieldCode="AR" term="%22Davis%2C+Amber%22">Davis, Amber</searchLink><br /><searchLink fieldCode="AR" term="%22Manning%2C+Courtney%22">Manning, Courtney</searchLink><br /><searchLink fieldCode="AR" term="%22Perry%2C+Lionel%22">Perry, Lionel</searchLink><br /><searchLink fieldCode="AR" term="%22Snapp%2C+Lauren%22">Snapp, Lauren</searchLink><br /><searchLink fieldCode="AR" term="%22Toy%2C+Arian%22">Toy, Arian</searchLink><br /><searchLink fieldCode="AR" term="%22Wheeler%2C+Kayla%22">Wheeler, Kayla</searchLink><br /><searchLink fieldCode="AR" term="%22Young%2C+Jeremy%22">Young, Jeremy</searchLink><br /><searchLink fieldCode="AR" term="%22Staker%2C+Bart%22">Staker, Bart</searchLink><br /><searchLink fieldCode="AR" term="%22Arakaki%2C+Tracy+L%2E%22">Arakaki, Tracy L.</searchLink><br /><searchLink fieldCode="AR" term="%22Abendroth%2C+Jan%22">Abendroth, Jan</searchLink><br /><searchLink fieldCode="AR" term="%22Subrahamanian%2C+Sandhya%22">Subrahamanian, Sandhya</searchLink><br /><searchLink fieldCode="AR" term="%22Edwards%2C+Thomas+E%2E%22">Edwards, Thomas E.</searchLink><br /><searchLink fieldCode="AR" term="%22Myler%2C+Peter+J%2E%22">Myler, Peter J.</searchLink><br /><searchLink fieldCode="AR" term="%22Asojo%2C+Oluwatoyin+A%2E%22">Asojo, Oluwatoyin A.</searchLink> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => Acta Crystallographica: Section F, Structural Biology Communications; Feb2022, Vol. 78 Issue 2, p59-65, 7p ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22GIARDIA+lamblia%22">GIARDIA lamblia</searchLink><br /><searchLink fieldCode="DE" term="%22PROTEIN+structure%22">PROTEIN structure</searchLink><br /><searchLink fieldCode="DE" term="%22CRYSTAL+structure%22">CRYSTAL structure</searchLink><br /><searchLink fieldCode="DE" term="%22SMALL+molecules%22">SMALL molecules</searchLink><br /><searchLink fieldCode="DE" term="%22GIARDIASIS%22">GIARDIASIS</searchLink><br /><searchLink fieldCode="DE" term="%22COMMUNICABLE+diseases%22">COMMUNICABLE diseases</searchLink> ) Array ( [Name] => SubjectCompany [Label] => Company/Entity [Group] => Su [Data] => <searchLink fieldCode="CO" term="%22HAMPTON+University+%28Va%2E%29%22">HAMPTON University (Va.)</searchLink> ) Array ( [Name] => Abstract [Label] => Abstract [Group] => Ab [Data] => Giardiasis is the most prevalent diarrheal disease globally and affects humans and animals. It is a significant problem in developing countries, the number one cause of travelers' diarrhea and affects children and immunocompromised individuals, especially HIV‐infected individuals. Giardiasis is treated with antibiotics (tinidazole and metronidazole) that are also used for other infections such as trichomoniasis. The ongoing search for new therapeutics for giardiasis includes characterizing the structure and function of proteins from the causative protozoan Giardia lamblia. These proteins include hypothetical proteins that share 30% sequence identity or less with proteins of known structure. Here, the atomic resolution structure of a 15.6 kDa protein was determined by molecular replacement. The structure has the two‐layer αβ‐sandwich topology observed in the prototypical endoribonucleases L‐PSPs (liver perchloric acid‐soluble proteins) with conserved allosteric active sites containing small molecules from the crystallization solution. This article is an educational collaboration between Hampton University and the Seattle Structural Genomics Center for Infectious Disease. [ABSTRACT FROM AUTHOR] ) Array ( [Name] => Abstract [Label] => [Group] => Ab [Data] => <i>Copyright of Acta Crystallographica: Section F, Structural Biology Communications is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) ) |
| RecordInfo |
Array
(
[BibEntity] => Array
(
[Identifiers] => Array
(
[0] => Array
(
[Type] => doi
[Value] => 10.1107/S2053230X21013595
)
)
[Languages] => Array
(
[0] => Array
(
[Code] => eng
[Text] => English
)
)
[PhysicalDescription] => Array
(
[Pagination] => Array
(
[PageCount] => 7
[StartPage] => 59
)
)
[Subjects] => Array
(
[0] => Array
(
[SubjectFull] => HAMPTON University (Va.)
[Type] => general
)
[1] => Array
(
[SubjectFull] => GIARDIA lamblia
[Type] => general
)
[2] => Array
(
[SubjectFull] => PROTEIN structure
[Type] => general
)
[3] => Array
(
[SubjectFull] => CRYSTAL structure
[Type] => general
)
[4] => Array
(
[SubjectFull] => SMALL molecules
[Type] => general
)
[5] => Array
(
[SubjectFull] => GIARDIASIS
[Type] => general
)
[6] => Array
(
[SubjectFull] => COMMUNICABLE diseases
[Type] => general
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Crystal structure of a hypothetical protein from Giardia lamblia.
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Beard, Dylan K.
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Bristol, Seonna
)
)
)
[2] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Cosby, Kayla
)
)
)
[3] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Davis, Amber
)
)
)
[4] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Manning, Courtney
)
)
)
[5] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Perry, Lionel
)
)
)
[6] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Snapp, Lauren
)
)
)
[7] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Toy, Arian
)
)
)
[8] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Wheeler, Kayla
)
)
)
[9] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Young, Jeremy
)
)
)
[10] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Staker, Bart
)
)
)
[11] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Arakaki, Tracy L.
)
)
)
[12] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Abendroth, Jan
)
)
)
[13] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Subrahamanian, Sandhya
)
)
)
[14] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Edwards, Thomas E.
)
)
)
[15] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Myler, Peter J.
)
)
)
[16] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Asojo, Oluwatoyin A.
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 01
[M] => 02
[Text] => Feb2022
[Type] => published
[Y] => 2022
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-print
[Value] => 2053230X
)
)
[Numbering] => Array
(
[0] => Array
(
[Type] => volume
[Value] => 78
)
[1] => Array
(
[Type] => issue
[Value] => 2
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Acta Crystallographica: Section F, Structural Biology Communications
[Type] => main
)
)
)
)
)
)
)
|
| IllustrationInfo |