دورية أكاديمية
Prevention of HIV-1 TAT Protein-Induced Peripheral Neuropathy and Mitochondrial Disruption by the Antimuscarinic Pirenzepine.
العنوان: | Prevention of HIV-1 TAT Protein-Induced Peripheral Neuropathy and Mitochondrial Disruption by the Antimuscarinic Pirenzepine. |
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المؤلفون: | Han, May Madi, Frizzi, Katie E., Ellis, Ronald J., Calcutt, Nigel A., Fields, Jerel Adam |
المصدر: | Frontiers in Neurology; 6/15/2021, Vol. 12, p1-10, 10p |
مصطلحات موضوعية: | PERIPHERAL neuropathy, HIV, LABORATORY mice, SCIATIC nerve injuries, MOTOR neuron diseases, MITOCHONDRIA |
الشركة/الكيان: | UNITED States. Food & Drug Administration |
مستخلص: | HIV-associated distal sensory polyneuropathy (HIV-DSP) affects about one third of people with HIV and is characterized by distal degeneration of axons. The pathogenesis of HIV-DSP is not known and there is currently no FDA-approved treatment. HIV trans-activator of transcription (TAT) is associated with mitochondrial dysfunction and neurotoxicity in the brain and may play a role in the pathogenesis of HIV-DSP. In the present study, we measured indices of peripheral neuropathy in the doxycycline (DOX)-inducible HIV-TAT (iTAT) transgenic mouse and investigated the therapeutic efficacy of a selective muscarinic subtype-1 receptor (M |
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قاعدة البيانات: | Complementary Index |
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