دورية أكاديمية
An Update on the Role of Leptin in the Immuno-Metabolism of Cartilage.
| العنوان: | An Update on the Role of Leptin in the Immuno-Metabolism of Cartilage. |
|---|---|
| المؤلفون: | Cordero-Barreal, Alfonso, González-Rodríguez, María, Ruiz-Fernández, Clara, Eldjoudi, Djedjiga Ait, AbdElHafez, Yousof Ramadan Farrag, Lago, Francisca, Conde, Javier, Gómez, Rodolfo, González-Gay, Miguel Angel, Mobasheri, Ali, Pino, Jesus, Gualillo, Oreste, Falchetti, Alberto, Kralisch, Susan |
| المصدر: | International Journal of Molecular Sciences; Mar2021, Vol. 22 Issue 5, p2411-2411, 1p |
| مصطلحات موضوعية: | LEPTIN, LEPTIN receptors, CELL receptors, CARTILAGE, SYSTEMIC lupus erythematosus, CARTILAGE cells |
| مستخلص: | Since its discovery in 1994, leptin has been considered as an adipokine with pleiotropic effects. In this review, we summarize the actual information about the impact of this hormone on cartilage metabolism and pathology. Leptin signalling depends on the interaction with leptin receptor LEPR, being the long isoform of the receptor (LEPRb) the one with more efficient intracellular signalling. Chondrocytes express the long isoform of the leptin receptor and in these cells, leptin signalling, alone or in combination with other molecules, induces the expression of pro-inflammatory molecules and cartilage degenerative enzymes. Leptin has been shown to increase the proliferation and activation of immune cells, increasing the severity of immune degenerative cartilage diseases. Leptin expression in serum and synovial fluid are related to degenerative diseases such as osteoarthritis (OA), rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Inhibition of leptin signalling showed to have protective effects in these diseases showing the key role of leptin in cartilage degeneration. [ABSTRACT FROM AUTHOR] |
| Copyright of International Journal of Molecular Sciences is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| قاعدة البيانات: | Complementary Index |
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