دورية أكاديمية
Hyperglycemia But Not Hyperinsulinemia Is Favorable for Exercise in Type 1 Diabetes: A Pilot Study.
العنوان: | Hyperglycemia But Not Hyperinsulinemia Is Favorable for Exercise in Type 1 Diabetes: A Pilot Study. |
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المؤلفون: | Romeres, Davide, Olson, Karen, Carter, Rickey, Cobelli, Claudio, Dalla Man, Chiara, Basu, Ananda, Basu, Rita |
المصدر: | Diabetes Care; Sep2020, Vol. 43 Issue 9, p2176-2182, 7p |
مصطلحات موضوعية: | TYPE 1 diabetes, HYPERGLYCEMIA, HYPERINSULINISM, PILOT projects, EXERCISE, GLUCOSE metabolism, ENERGY metabolism, RESEARCH, GLUCOSE clamp technique, RESEARCH methodology, BLOOD sugar, MEDICAL cooperation, EVALUATION research, INSULIN, COMPARATIVE studies, RANDOMIZED controlled trials, RESEARCH funding, DISEASE complications |
مستخلص: | |
Copyright of Diabetes Care is the property of American Diabetes Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
قاعدة البيانات: | Complementary Index |
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Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Romeres%2C+Davide%22">Romeres, Davide</searchLink><br /><searchLink fieldCode="AR" term="%22Olson%2C+Karen%22">Olson, Karen</searchLink><br /><searchLink fieldCode="AR" term="%22Carter%2C+Rickey%22">Carter, Rickey</searchLink><br /><searchLink fieldCode="AR" term="%22Cobelli%2C+Claudio%22">Cobelli, Claudio</searchLink><br /><searchLink fieldCode="AR" term="%22Dalla+Man%2C+Chiara%22">Dalla Man, Chiara</searchLink><br /><searchLink fieldCode="AR" term="%22Basu%2C+Ananda%22">Basu, Ananda</searchLink><br /><searchLink fieldCode="AR" term="%22Basu%2C+Rita%22">Basu, Rita</searchLink> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => Diabetes Care; Sep2020, Vol. 43 Issue 9, p2176-2182, 7p ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22TYPE+1+diabetes%22">TYPE 1 diabetes</searchLink><br /><searchLink fieldCode="DE" term="%22HYPERGLYCEMIA%22">HYPERGLYCEMIA</searchLink><br /><searchLink fieldCode="DE" term="%22HYPERINSULINISM%22">HYPERINSULINISM</searchLink><br /><searchLink fieldCode="DE" term="%22PILOT+projects%22">PILOT projects</searchLink><br /><searchLink fieldCode="DE" term="%22EXERCISE%22">EXERCISE</searchLink><br /><searchLink fieldCode="DE" term="%22GLUCOSE+metabolism%22">GLUCOSE metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22ENERGY+metabolism%22">ENERGY metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22RESEARCH%22">RESEARCH</searchLink><br /><searchLink fieldCode="DE" term="%22GLUCOSE+clamp+technique%22">GLUCOSE clamp technique</searchLink><br /><searchLink fieldCode="DE" term="%22RESEARCH+methodology%22">RESEARCH methodology</searchLink><br /><searchLink fieldCode="DE" term="%22BLOOD+sugar%22">BLOOD sugar</searchLink><br /><searchLink fieldCode="DE" term="%22MEDICAL+cooperation%22">MEDICAL cooperation</searchLink><br /><searchLink fieldCode="DE" term="%22EVALUATION+research%22">EVALUATION research</searchLink><br /><searchLink fieldCode="DE" term="%22INSULIN%22">INSULIN</searchLink><br /><searchLink fieldCode="DE" term="%22COMPARATIVE+studies%22">COMPARATIVE studies</searchLink><br /><searchLink fieldCode="DE" term="%22RANDOMIZED+controlled+trials%22">RANDOMIZED controlled trials</searchLink><br /><searchLink fieldCode="DE" term="%22RESEARCH+funding%22">RESEARCH funding</searchLink><br /><searchLink fieldCode="DE" term="%22DISEASE+complications%22">DISEASE complications</searchLink> ) Array ( [Name] => Abstract [Label] => Abstract [Group] => Ab [Data] => <bold>Objective: </bold>To distinguish the effects of hyperglycemia and hyperinsulinemia on exercise-induced increases in Rd and endogenous glucose production (EGP) in type 1 diabetes.<bold>Research Design and Methods: </bold>We studied six participants without diabetes and six participants with type 1 diabetes on three visits in random order for the following: euglycemia, low insulin (EuLoI); euglycemia, high insulin (EuHiI); and hyperglycemia, low insulin (HyLoI). Glucose fluxes were measured using [6,6-2H2] glucose before, during, and after 60 min of exercise.<bold>Results: </bold>Rd increased (P < 0.01) with exercise within groups, while peak Rd during exercise was lower (P < 0.01) in participants with type 1 diabetes than participants without diabetes during all visits. In type 1 diabetes participants, EGP increased (P < 0.001) with exercise during EuLoI and HyLoI but not during EuHiI. This demonstrates that hyperinsulinemia, but not hyperglycemia, blunts the compensatory exercise-induced increase in EGP in type 1 diabetes.<bold>Conclusions: </bold>The data from this pilot study indicate that 1) exercise-induced compensatory increase in EGP was inhibited in participants with type 1 diabetes with hyperinsulinemia but not with hyperglycemia; 2) in contrast, in participants without diabetes, exercise-induced increase in EGP was inhibited only during combined hyperinsulinemia and hyperglycemia. Taken together, these results suggest that low insulin coupled with euglycemia or modest hyperglycemia appear to be the most favorable milieu for type 1 diabetes during exercise. [ABSTRACT FROM AUTHOR] ) Array ( [Name] => Abstract [Label] => [Group] => Ab [Data] => <i>Copyright of Diabetes Care is the property of American Diabetes Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) ) |
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