دورية أكاديمية
Compression force sensing regulates integrin αIIbβ3 adhesive function on diabetic platelets.
العنوان: | Compression force sensing regulates integrin α |
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المؤلفون: | Lining Ju, McFadyen, James D., Al-Daher, Saheb, Alwis, Imala, Yunfeng Chen, Tønnesen, Lotte L., Maiocchi, Sophie, Coulter, Brianna, Calkin, Anna C., Felner, Eric I., Neale Cohen, Yuping Yuan, Schoenwaelder, Simone M., Cooper, Mark E., Cheng Zhu, Jackson, Shaun P. |
المصدر: | Nature Communications; 3/14/2018, Vol. 9 Issue 1, p1-16, 16p, 1 Chart, 7 Graphs |
مستخلص: | Diabetes is associated with an exaggerated platelet thrombotic response at sites of vascular injury. Biomechanical forces regulate platelet activation, although the impact of diabetes on this process remains ill-defined. Using a biomembrane force probe (BFP), we demonstrate that compressive force activates integrin αα |
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قاعدة البيانات: | Complementary Index |