دورية أكاديمية
Cord Blood CD8+ T Cells Have a Natural Propensity to Express IL-4 in a Fatty Acid Metabolism and Caspase Activation-Dependent Manner.
العنوان: | Cord Blood CD8+ T Cells Have a Natural Propensity to Express IL-4 in a Fatty Acid Metabolism and Caspase Activation-Dependent Manner. |
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المؤلفون: | Zhang, Yuxia, Maksimovic, Jovana, Huang, Bing, De Souza, David Peter, Naselli, Gaetano, Chen, Huan, Zhang, Li, Weng, Kai, Liang, Hanquan, Xu, Yanhui, Wentworth, John M., Huntington, Nicholas D., Oshlack, Alicia, Gong, Sitang, Kallies, Axel, Vuillermin, Peter, Yang, Min, Harrison, Leonard C. |
المصدر: | Frontiers in Immunology; 4/25/2018, p1-N.PAG, 13p |
مصطلحات موضوعية: | FATTY acids, METABOLISM, PHENOTYPES |
مستخلص: | How T cells differentiate in the neonate may critically determine the ability of the infant to cope with infections, respond to vaccines and avert allergies. Previously, we found that naïve cord blood CD4+ T cells differentiated toward an IL-4-expressing phenotype when activated in the presence of TGF-β and monocyte-derived inflammatory cytokines, the latter are more highly secreted by infants who developed food allergy. Here, we show that in the absence of IL-2 or IL-12, naïve cord blood CD8+ T cells have a natural propensity to differentiate into IL-4-producing non-classic T |
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قاعدة البيانات: | Complementary Index |
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