دورية أكاديمية
Association Between a Polymorphism (rs2071214) in Baculoviral IAP Repeat Containing 5 Gene (BIRC5) and Ischemic Stroke in Korean Population.
| العنوان: | Association Between a Polymorphism (rs2071214) in Baculoviral IAP Repeat Containing 5 Gene (BIRC5) and Ischemic Stroke in Korean Population. |
|---|---|
| المؤلفون: | Jinmann Chon, Hee-Sang Kim, Dong Hwan Yun, Seung Don Yoo, Dong Hwan Kim, Seung Ah Lee, Su Kang Kim, Hae Jeong Park, Joo-Ho Chung, Sungjoon Chung, Jinah Yeo |
| المصدر: | Annals of Rehabilitation Medicine; 2016, Vol. 40 Issue 3, p392-400, 9p |
| مصطلحات موضوعية: | SURVIVIN (Protein), APOPTOSIS inhibition, GENETIC polymorphism research, CEREBRAL infarction, SINGLE nucleotide polymorphisms, STROKE patients |
| مستخلص: | Objective To investigate whether baculoviral inhibitor of apoptosis (IAP) repeat containing 5 gene (BIRC5) polymorphisms are associated with the development and clinical phenotypes of ischemic stroke in Korea population. Methods We enrolled 121 ischemic stroke patients and 291 control subjects. Ischemic stroke patients were divided into subgroups according to the scores of National Institutes of Health Stroke Survey (<6 or =6) and Modified Barthel Index (<60 or =60). Single nucleotide polymorphisms (SNPs) of BIRC5 (rs3764383 and rs2071214) were selected and genotyped by direct sequencing for all subjects. Multiple logistic regression models (codominant 1 and 2, dominant, recessive, overdominant and log-additive) were used to estimate odds ratios (ORs), 95% confidence intervals (CIs), and p-values. Results In analysis of stroke susceptibility, the genotype and allele frequencies of rs3764383 exhibited no difference between the control group and the ischemic stroke group. SNP rs2071214 was associated with ischemic stroke in the codominant (p=0.003), dominant (p=0.002), overdominant (p=0.005), and log-additive (p=0.008) models, respectively. The G allele frequency of rs2071214 was significantly (p=0.009) associated with susceptibility for ischemic stroke (OR, 1.57; 95% CI, 1.12-2.21). However, in the analysis for clinical phenotype, no SNP of the BIRC5 gene was found to be associated with ischemic stroke. Conclusion These results suggest that a missense SNP (rs2071214) of BIRC5 may be associated with the development of ischemic stroke in the Korean population. [ABSTRACT FROM AUTHOR] |
| Copyright of Annals of Rehabilitation Medicine is the property of Korean Academy of Rehabilitation Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| قاعدة البيانات: | Complementary Index |
Full Text Finder | ResultId |
1 |
|---|---|
| Header |
edb Complementary Index 116641817 861 6 Academic Journal academicJournal 861.064147949219 |
| PLink |
https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edb&AN=116641817&custid=s6537998&authtype=sso |
| FullText |
Array
(
[Availability] => 0
)
Array ( [0] => Array ( [Url] => https://resolver.ebscohost.com/openurl?custid=s6537998&groupid=main&authtype=ip,guest&sid=EBSCO:edb&genre=article&issn=22340645&ISBN=&volume=40&issue=3&date=20160501&spage=392&pages=392-400&title=Annals of Rehabilitation Medicine&atitle=Association%20Between%20a%20Polymorphism%20%28rs2071214%29%20in%20Baculoviral%20IAP%20Repeat%20Containing%205%20Gene%20%28BIRC5%29%20and%20Ischemic%20Stroke%20in%20Korean%20Population.&id=DOI:10.5535/arm.2016.40.3.392 [Name] => Full Text Finder (s6537998api) [Category] => fullText [Text] => Full Text Finder [Icon] => https://imageserver.ebscohost.com/branding/images/FTF.gif [MouseOverText] => Full Text Finder ) ) |
| Items |
Array
(
[Name] => Title
[Label] => Title
[Group] => Ti
[Data] => Association Between a Polymorphism (rs2071214) in Baculoviral IAP Repeat Containing 5 Gene (BIRC5) and Ischemic Stroke in Korean Population.
)
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Jinmann+Chon%22">Jinmann Chon</searchLink><br /><searchLink fieldCode="AR" term="%22Hee-Sang+Kim%22">Hee-Sang Kim</searchLink><br /><searchLink fieldCode="AR" term="%22Dong+Hwan+Yun%22">Dong Hwan Yun</searchLink><br /><searchLink fieldCode="AR" term="%22Seung+Don+Yoo%22">Seung Don Yoo</searchLink><br /><searchLink fieldCode="AR" term="%22Dong+Hwan+Kim%22">Dong Hwan Kim</searchLink><br /><searchLink fieldCode="AR" term="%22Seung+Ah+Lee%22">Seung Ah Lee</searchLink><br /><searchLink fieldCode="AR" term="%22Su+Kang+Kim%22">Su Kang Kim</searchLink><br /><searchLink fieldCode="AR" term="%22Hae+Jeong+Park%22">Hae Jeong Park</searchLink><br /><searchLink fieldCode="AR" term="%22Joo-Ho+Chung%22">Joo-Ho Chung</searchLink><br /><searchLink fieldCode="AR" term="%22Sungjoon+Chung%22">Sungjoon Chung</searchLink><br /><searchLink fieldCode="AR" term="%22Jinah+Yeo%22">Jinah Yeo</searchLink> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => Annals of Rehabilitation Medicine; 2016, Vol. 40 Issue 3, p392-400, 9p ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22SURVIVIN+%28Protein%29%22">SURVIVIN (Protein)</searchLink><br /><searchLink fieldCode="DE" term="%22APOPTOSIS+inhibition%22">APOPTOSIS inhibition</searchLink><br /><searchLink fieldCode="DE" term="%22GENETIC+polymorphism+research%22">GENETIC polymorphism research</searchLink><br /><searchLink fieldCode="DE" term="%22CEREBRAL+infarction%22">CEREBRAL infarction</searchLink><br /><searchLink fieldCode="DE" term="%22SINGLE+nucleotide+polymorphisms%22">SINGLE nucleotide polymorphisms</searchLink><br /><searchLink fieldCode="DE" term="%22STROKE+patients%22">STROKE patients</searchLink> ) Array ( [Name] => Abstract [Label] => Abstract [Group] => Ab [Data] => Objective To investigate whether baculoviral inhibitor of apoptosis (IAP) repeat containing 5 gene (BIRC5) polymorphisms are associated with the development and clinical phenotypes of ischemic stroke in Korea population. Methods We enrolled 121 ischemic stroke patients and 291 control subjects. Ischemic stroke patients were divided into subgroups according to the scores of National Institutes of Health Stroke Survey (<6 or =6) and Modified Barthel Index (<60 or =60). Single nucleotide polymorphisms (SNPs) of BIRC5 (rs3764383 and rs2071214) were selected and genotyped by direct sequencing for all subjects. Multiple logistic regression models (codominant 1 and 2, dominant, recessive, overdominant and log-additive) were used to estimate odds ratios (ORs), 95% confidence intervals (CIs), and p-values. Results In analysis of stroke susceptibility, the genotype and allele frequencies of rs3764383 exhibited no difference between the control group and the ischemic stroke group. SNP rs2071214 was associated with ischemic stroke in the codominant (p=0.003), dominant (p=0.002), overdominant (p=0.005), and log-additive (p=0.008) models, respectively. The G allele frequency of rs2071214 was significantly (p=0.009) associated with susceptibility for ischemic stroke (OR, 1.57; 95% CI, 1.12-2.21). However, in the analysis for clinical phenotype, no SNP of the BIRC5 gene was found to be associated with ischemic stroke. Conclusion These results suggest that a missense SNP (rs2071214) of BIRC5 may be associated with the development of ischemic stroke in the Korean population. [ABSTRACT FROM AUTHOR] ) Array ( [Name] => Abstract [Label] => [Group] => Ab [Data] => <i>Copyright of Annals of Rehabilitation Medicine is the property of Korean Academy of Rehabilitation Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) ) |
| RecordInfo |
Array
(
[BibEntity] => Array
(
[Identifiers] => Array
(
[0] => Array
(
[Type] => doi
[Value] => 10.5535/arm.2016.40.3.392
)
)
[Languages] => Array
(
[0] => Array
(
[Code] => eng
[Text] => English
)
)
[PhysicalDescription] => Array
(
[Pagination] => Array
(
[PageCount] => 9
[StartPage] => 392
)
)
[Subjects] => Array
(
[0] => Array
(
[SubjectFull] => SURVIVIN (Protein)
[Type] => general
)
[1] => Array
(
[SubjectFull] => APOPTOSIS inhibition
[Type] => general
)
[2] => Array
(
[SubjectFull] => GENETIC polymorphism research
[Type] => general
)
[3] => Array
(
[SubjectFull] => CEREBRAL infarction
[Type] => general
)
[4] => Array
(
[SubjectFull] => SINGLE nucleotide polymorphisms
[Type] => general
)
[5] => Array
(
[SubjectFull] => STROKE patients
[Type] => general
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Association Between a Polymorphism (rs2071214) in Baculoviral IAP Repeat Containing 5 Gene (BIRC5) and Ischemic Stroke in Korean Population.
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Jinmann Chon
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Hee-Sang Kim
)
)
)
[2] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Dong Hwan Yun
)
)
)
[3] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Seung Don Yoo
)
)
)
[4] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Dong Hwan Kim
)
)
)
[5] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Seung Ah Lee
)
)
)
[6] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Su Kang Kim
)
)
)
[7] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Hae Jeong Park
)
)
)
[8] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Joo-Ho Chung
)
)
)
[9] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Sungjoon Chung
)
)
)
[10] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Jinah Yeo
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 01
[M] => 05
[Text] => 2016
[Type] => published
[Y] => 2016
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-print
[Value] => 22340645
)
)
[Numbering] => Array
(
[0] => Array
(
[Type] => volume
[Value] => 40
)
[1] => Array
(
[Type] => issue
[Value] => 3
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Annals of Rehabilitation Medicine
[Type] => main
)
)
)
)
)
)
)
|
| IllustrationInfo |