دورية أكاديمية
Antifungal de-escalation was not associated with adverse outcome in critically ill patients treated for invasive candidiasis: post hoc analyses of the AmarCAND2 study data.
| العنوان: | Antifungal de-escalation was not associated with adverse outcome in critically ill patients treated for invasive candidiasis: post hoc analyses of the AmarCAND2 study data. |
|---|---|
| المؤلفون: | Bailly, Sébastien, Leroy, Olivier, Montravers, Philippe, Constantin, Jean-Michel, Dupont, Hervé, Guillemot, Didier, Lortholary, Olivier, Mira, Jean-Paul, Perrigault, Pierre-François, Gangneux, Jean-Pierre, Azoulay, Elie, Timsit, Jean-François |
| المصدر: | Intensive Care Medicine; Nov2015, Vol. 41 Issue 11, p1931-1940, 10p, 1 Diagram, 4 Charts |
| مصطلحات موضوعية: | ANTIFUNGAL agents, CATASTROPHIC illness, INTENSIVE care units, LONGITUDINAL method, MEDICAL care, EVALUATION of medical care, MEDICAL cooperation, SCIENTIFIC observation, PATIENTS, PEPTIDES, RESEARCH, SURVIVAL analysis (Biometry), COMORBIDITY, LOGISTIC regression analysis, SEVERITY of illness index, DISEASE progression, HOSPITAL mortality, FLUCONAZOLE, INVASIVE candidiasis, PREVENTION, DIAGNOSIS, THERAPEUTICS |
| مصطلحات جغرافية: | FRANCE |
| مستخلص: | |
| Copyright of Intensive Care Medicine is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| قاعدة البيانات: | Complementary Index |
| ResultId |
1 |
|---|---|
| Header |
edb Complementary Index 109926566 861 6 Academic Journal academicJournal 860.796447753906 |
| PLink |
https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edb&AN=109926566&custid=s6537998&authtype=sso |
| FullText |
Array
(
[Availability] => 0
)
|
| Items |
Array
(
[Name] => Title
[Label] => Title
[Group] => Ti
[Data] => Antifungal de-escalation was not associated with adverse outcome in critically ill patients treated for invasive candidiasis: post hoc analyses of the AmarCAND2 study data.
)
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Bailly%2C+Sébastien%22">Bailly, Sébastien</searchLink><br /><searchLink fieldCode="AR" term="%22Leroy%2C+Olivier%22">Leroy, Olivier</searchLink><br /><searchLink fieldCode="AR" term="%22Montravers%2C+Philippe%22">Montravers, Philippe</searchLink><br /><searchLink fieldCode="AR" term="%22Constantin%2C+Jean-Michel%22">Constantin, Jean-Michel</searchLink><br /><searchLink fieldCode="AR" term="%22Dupont%2C+Hervé%22">Dupont, Hervé</searchLink><br /><searchLink fieldCode="AR" term="%22Guillemot%2C+Didier%22">Guillemot, Didier</searchLink><br /><searchLink fieldCode="AR" term="%22Lortholary%2C+Olivier%22">Lortholary, Olivier</searchLink><br /><searchLink fieldCode="AR" term="%22Mira%2C+Jean-Paul%22">Mira, Jean-Paul</searchLink><br /><searchLink fieldCode="AR" term="%22Perrigault%2C+Pierre-François%22">Perrigault, Pierre-François</searchLink><br /><searchLink fieldCode="AR" term="%22Gangneux%2C+Jean-Pierre%22">Gangneux, Jean-Pierre</searchLink><br /><searchLink fieldCode="AR" term="%22Azoulay%2C+Elie%22">Azoulay, Elie</searchLink><br /><searchLink fieldCode="AR" term="%22Timsit%2C+Jean-François%22">Timsit, Jean-François</searchLink> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => Intensive Care Medicine; Nov2015, Vol. 41 Issue 11, p1931-1940, 10p, 1 Diagram, 4 Charts ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22ANTIFUNGAL+agents%22">ANTIFUNGAL agents</searchLink><br /><searchLink fieldCode="DE" term="%22CATASTROPHIC+illness%22">CATASTROPHIC illness</searchLink><br /><searchLink fieldCode="DE" term="%22INTENSIVE+care+units%22">INTENSIVE care units</searchLink><br /><searchLink fieldCode="DE" term="%22LONGITUDINAL+method%22">LONGITUDINAL method</searchLink><br /><searchLink fieldCode="DE" term="%22MEDICAL+care%22">MEDICAL care</searchLink><br /><searchLink fieldCode="DE" term="%22EVALUATION+of+medical+care%22">EVALUATION of medical care</searchLink><br /><searchLink fieldCode="DE" term="%22MEDICAL+cooperation%22">MEDICAL cooperation</searchLink><br /><searchLink fieldCode="DE" term="%22SCIENTIFIC+observation%22">SCIENTIFIC observation</searchLink><br /><searchLink fieldCode="DE" term="%22PATIENTS%22">PATIENTS</searchLink><br /><searchLink fieldCode="DE" term="%22PEPTIDES%22">PEPTIDES</searchLink><br /><searchLink fieldCode="DE" term="%22RESEARCH%22">RESEARCH</searchLink><br /><searchLink fieldCode="DE" term="%22SURVIVAL+analysis+%28Biometry%29%22">SURVIVAL analysis (Biometry)</searchLink><br /><searchLink fieldCode="DE" term="%22COMORBIDITY%22">COMORBIDITY</searchLink><br /><searchLink fieldCode="DE" term="%22LOGISTIC+regression+analysis%22">LOGISTIC regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22SEVERITY+of+illness+index%22">SEVERITY of illness index</searchLink><br /><searchLink fieldCode="DE" term="%22DISEASE+progression%22">DISEASE progression</searchLink><br /><searchLink fieldCode="DE" term="%22HOSPITAL+mortality%22">HOSPITAL mortality</searchLink><br /><searchLink fieldCode="DE" term="%22FLUCONAZOLE%22">FLUCONAZOLE</searchLink><br /><searchLink fieldCode="DE" term="%22INVASIVE+candidiasis%22">INVASIVE candidiasis</searchLink><br /><searchLink fieldCode="DE" term="%22PREVENTION%22">PREVENTION</searchLink><br /><searchLink fieldCode="DE" term="%22DIAGNOSIS%22">DIAGNOSIS</searchLink><br /><searchLink fieldCode="DE" term="%22THERAPEUTICS%22">THERAPEUTICS</searchLink> ) Array ( [Name] => SubjectGeographic [Label] => Geographic Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22FRANCE%22">FRANCE</searchLink> ) Array ( [Name] => Abstract [Label] => Abstract [Group] => Ab [Data] => <bold>Purpose: </bold>Systemic antifungal therapy (SAT) of invasive candidiasis needs to be initiated immediately upon clinical suspicion. Controversies exist about adequate time and potential harm of antifungal de-escalation (DE) in documented and suspected candidiasis in ICU patients. Our objective was to investigate whether de-escalation within 5 days of antifungal initiation is associated with an increase of the 28-day mortality in SAT-treated non-neutropenic adult ICU patients.<bold>Methods: </bold>From the 835 non-neutropenic adults recruited in the multicenter prospective observational AmarCAND2 study, we selected the patients receiving systemic antifungal therapy for a documented or suspected invasive candidiasis in the ICU and who were still alive 5 days after SAT initiation. They were included into two groups according to the occurrence of observed SAT de-escalation before day 6. The average causal SAT de-escalation effect on 28-day mortality was evaluated by using a double robust estimation.<bold>Results: </bold>Among the 647 included patients, early de-escalation at day 5 after antifungal initiation occurred in 142 patients (22%), including 48 (34%) patients whose SAT was stopped before day 6. After adjustment for the baseline confounders, early SAT de-escalation was the solely factor not associated with increased 28-day mortality (RR 1.12, 95% CI 0.76-1.66).<bold>Conclusion: </bold>In non-neutropenic critically ill adult patients with documented or suspected invasive candidiasis, SAT de-escalation within 5 days was not related to increased day-28 mortality but it was associated with decreased SAT consumption. These results suggest for the first time that SAT de-escalation may be safe in these patients. [ABSTRACT FROM AUTHOR] ) Array ( [Name] => Abstract [Label] => [Group] => Ab [Data] => <i>Copyright of Intensive Care Medicine is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) ) |
| RecordInfo |
Array
(
[BibEntity] => Array
(
[Identifiers] => Array
(
[0] => Array
(
[Type] => doi
[Value] => 10.1007/s00134-015-4053-1
)
)
[Languages] => Array
(
[0] => Array
(
[Code] => eng
[Text] => English
)
)
[PhysicalDescription] => Array
(
[Pagination] => Array
(
[PageCount] => 10
[StartPage] => 1931
)
)
[Subjects] => Array
(
[0] => Array
(
[SubjectFull] => FRANCE
[Type] => general
)
[1] => Array
(
[SubjectFull] => ANTIFUNGAL agents
[Type] => general
)
[2] => Array
(
[SubjectFull] => CATASTROPHIC illness
[Type] => general
)
[3] => Array
(
[SubjectFull] => INTENSIVE care units
[Type] => general
)
[4] => Array
(
[SubjectFull] => LONGITUDINAL method
[Type] => general
)
[5] => Array
(
[SubjectFull] => MEDICAL care
[Type] => general
)
[6] => Array
(
[SubjectFull] => EVALUATION of medical care
[Type] => general
)
[7] => Array
(
[SubjectFull] => MEDICAL cooperation
[Type] => general
)
[8] => Array
(
[SubjectFull] => SCIENTIFIC observation
[Type] => general
)
[9] => Array
(
[SubjectFull] => PATIENTS
[Type] => general
)
[10] => Array
(
[SubjectFull] => PEPTIDES
[Type] => general
)
[11] => Array
(
[SubjectFull] => RESEARCH
[Type] => general
)
[12] => Array
(
[SubjectFull] => SURVIVAL analysis (Biometry)
[Type] => general
)
[13] => Array
(
[SubjectFull] => COMORBIDITY
[Type] => general
)
[14] => Array
(
[SubjectFull] => LOGISTIC regression analysis
[Type] => general
)
[15] => Array
(
[SubjectFull] => SEVERITY of illness index
[Type] => general
)
[16] => Array
(
[SubjectFull] => DISEASE progression
[Type] => general
)
[17] => Array
(
[SubjectFull] => HOSPITAL mortality
[Type] => general
)
[18] => Array
(
[SubjectFull] => FLUCONAZOLE
[Type] => general
)
[19] => Array
(
[SubjectFull] => INVASIVE candidiasis
[Type] => general
)
[20] => Array
(
[SubjectFull] => PREVENTION
[Type] => general
)
[21] => Array
(
[SubjectFull] => DIAGNOSIS
[Type] => general
)
[22] => Array
(
[SubjectFull] => THERAPEUTICS
[Type] => general
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Antifungal de-escalation was not associated with adverse outcome in critically ill patients treated for invasive candidiasis: post hoc analyses of the AmarCAND2 study data.
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Bailly, Sébastien
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Leroy, Olivier
)
)
)
[2] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Montravers, Philippe
)
)
)
[3] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Constantin, Jean-Michel
)
)
)
[4] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Dupont, Hervé
)
)
)
[5] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Guillemot, Didier
)
)
)
[6] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Lortholary, Olivier
)
)
)
[7] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Mira, Jean-Paul
)
)
)
[8] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Perrigault, Pierre-François
)
)
)
[9] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Gangneux, Jean-Pierre
)
)
)
[10] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Azoulay, Elie
)
)
)
[11] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Timsit, Jean-François
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 01
[M] => 11
[Text] => Nov2015
[Type] => published
[Y] => 2015
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-print
[Value] => 03424642
)
)
[Numbering] => Array
(
[0] => Array
(
[Type] => volume
[Value] => 41
)
[1] => Array
(
[Type] => issue
[Value] => 11
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Intensive Care Medicine
[Type] => main
)
)
)
)
)
)
)
|
| IllustrationInfo |