دورية أكاديمية
Patches of Disorganization in the Neocortex of Children with Autism.
| العنوان: | Patches of Disorganization in the Neocortex of Children with Autism. |
|---|---|
| المؤلفون: | Stoner, Rich1,2, Chow, Maggie L.1,2, Boyle, Maureen P.1,2,3, Sunkin, Susan M.3, Mouton, Peter R.4, Roy, Subhojit2,5, Wynshaw-Boris, Anthony6, Colamarino, Sophia A.7, Lein, Ed S.3, Courchesne, Eric1,2 ecourchesne@ucsd.edu |
| المصدر: | New England Journal of Medicine. 3/27/2014, Vol. 370 Issue 13, p1209-1219. 11p. |
| مصطلحات موضوعية: | *CYTOARCHITECTONICS, *CELL anatomy, *PREFRONTAL cortex, *AUTISTIC children, *AUTISM research |
| مستخلص: | The article discusses the results of a study which observed the focal patches of abnormal laminar cytoarchitecture and cortical disorganization of neurons in prefrontal and temporal cortical tissue from 10 of 11 children with autism and from 1 of 11 of unaffected children. Topics include heterogeneity between cases that were most abnormal in the patches, layers most affected by the pathological features, and the probability of dysregulation of layer formation at prenatal developmental stages. |
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