دورية أكاديمية
Genetically determined ABCB5 functionality correlates with pigmentation phenotype and melanoma risk.
| العنوان: | Genetically determined ABCB5 functionality correlates with pigmentation phenotype and melanoma risk. |
|---|---|
| المؤلفون: | Lin, Jennifer Y.1, Zhang, Mingfeng1, Schatton, Tobias1, Wilson, Brian J.1,2, Alloo, Allireza1,2, Ma, Jie1,2, Qureshi, Abrar A.1, Frank, Natasha Y.3,4, Han, Jiali1,5 jiali.han@channing.harvard.edu, Frank, Markus H.1,2 markus.frank@childrens.harvard.edu |
| المصدر: | Biochemical & Biophysical Research Communications. Jul2013, Vol. 436 Issue 3, p536-542. 7p. |
| مصطلحات موضوعية: | *HUMAN skin color, *ATP-binding cassette transporter genetics, *MELANOMA, *CANCER stem cells, *PHENOTYPES, *ALLELES, *CANCER risk factors |
| مستخلص: | Highlights: [•] Results establish a first association of an ABCB5 SNP with melanoma risk. [•] The lower melanoma risk allele is also associated with enhanced pigmentation. [•] The lower melanoma risk allele confers impaired ABCB5 protein function. [•] Functional variation in a cancer stem cell gene can correlate with tumorigenesis. [•] Results have implications for melanoma risk assessment and prevention. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: | Academic Search Index |
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https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=asx&AN=88992969&custid=s6537998&authtype=sso |
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