دورية أكاديمية
Defective production of both leukemia inhibitory factor and type 2 T-helper cytokines by decidual T cells in unexplained recurrent abortions.
| العنوان: | Defective production of both leukemia inhibitory factor and type 2 T-helper cytokines by decidual T cells in unexplained recurrent abortions. |
|---|---|
| المؤلفون: | Piccinni, Marie-Pierre, Beloni, Lucio, Livi, Claudia, Maggi, Enrico, Scarselli, Gianfranco, Romagnani, Sergio |
| المصدر: | Nature Medicine. Sep1998, Vol. 4 Issue 9, p1020. 5p. |
| مصطلحات موضوعية: | *LEUKEMIA inhibitory factor, *T cells, *ABORTION |
| مستخلص: | Leukemia inhibitory factor is essential for embryo implantation, and a shift from type 1 T-helper to type 2 T-helper response at the fetal?maternal interface may contribute to successful pregnancy. We show that LIF production is associated with type 2 T-helper cells, is upregulated by IL-4 and progesterone and is downregulated by IL-12, IFN-γ and IFN-α. We also show a decreased production of LIF, IL-4 and IL-10 by decidual T cells of women with unexplained recurrent abortions in comparison with that of women with normal gestation. The defective production of LIF and/or type 2 T-helper cytokines may contribute to the development of unexplained recurrent abortions. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: | Academic Search Index |
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