دورية أكاديمية
Nutrient excess and altered mitochondrial proteome and function contribute to neurodegeneration in diabetes
| العنوان: | Nutrient excess and altered mitochondrial proteome and function contribute to neurodegeneration in diabetes |
|---|---|
| المؤلفون: | Chowdhury, Subir K. Roy1 skr_chowdhury@yahoo.ca, Dobrowsky, Rick T.2, Fernyhough, Paul1,3 |
| المصدر: | Mitochondrion. Nov2011, Vol. 11 Issue 6, p845-854. 10p. |
| مصطلحات موضوعية: | *DIABETES complications, *DIABETIC neuropathies, *NEURODEGENERATION, *NUTRITION disorders, *MITOCHONDRIAL pathology, *STREPTOZOTOCIN, *SENSORY neurons |
| مستخلص: | Abstract: Diabetic neuropathy is a major complication of diabetes that results in the progressive deterioration of the sensory nervous system. Mitochondrial dysfunction has been proposed to play an important role in the pathogenesis of the neurodegeneration observed in diabetic neuropathy. Our recent work has shown that mitochondrial dysfunction occurs in dorsal root ganglia (DRG) sensory neurons in streptozotocin (STZ) induced diabetic rodents. In neurons, the nutrient excess associated with prolonged diabetes may trigger a switching off of AMP kinase (AMPK) and/or silent information regulator T1 (SIRT1) signaling leading to impaired peroxisome proliferator-activated receptor γ coactivator-1 (PGC-1α) expression/activity and diminished mitochondrial activity. This review briefly summarizes the alterations of mitochondrial function and proteome in sensory neurons of STZ-diabetic rodents. We also discuss the possible involvement of AMPK/SIRT/PGC-1α pathway in other diabetic models and different tissues affected by diabetes. [Copyright &y& Elsevier] |
| قاعدة البيانات: | Academic Search Index |
| ResultId |
1 |
|---|---|
| Header |
asx Academic Search Index 67112069 1204 6 Academic Journal academicJournal 1204.06665039063 |
| PLink |
https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=asx&AN=67112069&custid=s6537998&authtype=sso |
| FullText |
Array
(
[Availability] => 0
)
|
| Items |
Array
(
[Name] => Title
[Label] => Title
[Group] => Ti
[Data] => Nutrient excess and altered mitochondrial proteome and function contribute to neurodegeneration in diabetes
)
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Chowdhury%2C+Subir+K%2E+Roy%22">Chowdhury, Subir K. Roy</searchLink><relatesTo>1</relatesTo><i> skr_chowdhury@yahoo.ca</i><br /><searchLink fieldCode="AR" term="%22Dobrowsky%2C+Rick+T%2E%22">Dobrowsky, Rick T.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Fernyhough%2C+Paul%22">Fernyhough, Paul</searchLink><relatesTo>1,3</relatesTo> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => <searchLink fieldCode="JN" term="%22Mitochondrion%22">Mitochondrion</searchLink>. Nov2011, Vol. 11 Issue 6, p845-854. 10p. ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => *<searchLink fieldCode="DE" term="%22DIABETES+complications%22">DIABETES complications</searchLink><br />*<searchLink fieldCode="DE" term="%22DIABETIC+neuropathies%22">DIABETIC neuropathies</searchLink><br />*<searchLink fieldCode="DE" term="%22NEURODEGENERATION%22">NEURODEGENERATION</searchLink><br />*<searchLink fieldCode="DE" term="%22NUTRITION+disorders%22">NUTRITION disorders</searchLink><br />*<searchLink fieldCode="DE" term="%22MITOCHONDRIAL+pathology%22">MITOCHONDRIAL pathology</searchLink><br />*<searchLink fieldCode="DE" term="%22STREPTOZOTOCIN%22">STREPTOZOTOCIN</searchLink><br />*<searchLink fieldCode="DE" term="%22SENSORY+neurons%22">SENSORY neurons</searchLink> ) Array ( [Name] => Abstract [Label] => Abstract [Group] => Ab [Data] => Abstract: Diabetic neuropathy is a major complication of diabetes that results in the progressive deterioration of the sensory nervous system. Mitochondrial dysfunction has been proposed to play an important role in the pathogenesis of the neurodegeneration observed in diabetic neuropathy. Our recent work has shown that mitochondrial dysfunction occurs in dorsal root ganglia (DRG) sensory neurons in streptozotocin (STZ) induced diabetic rodents. In neurons, the nutrient excess associated with prolonged diabetes may trigger a switching off of AMP kinase (AMPK) and/or silent information regulator T1 (SIRT1) signaling leading to impaired peroxisome proliferator-activated receptor γ coactivator-1 (PGC-1α) expression/activity and diminished mitochondrial activity. This review briefly summarizes the alterations of mitochondrial function and proteome in sensory neurons of STZ-diabetic rodents. We also discuss the possible involvement of AMPK/SIRT/PGC-1α pathway in other diabetic models and different tissues affected by diabetes. [Copyright &y& Elsevier] ) |
| RecordInfo |
Array
(
[BibEntity] => Array
(
[Identifiers] => Array
(
[0] => Array
(
[Type] => doi
[Value] => 10.1016/j.mito.2011.06.007
)
)
[Languages] => Array
(
[0] => Array
(
[Code] => eng
[Text] => English
)
)
[PhysicalDescription] => Array
(
[Pagination] => Array
(
[PageCount] => 10
[StartPage] => 845
)
)
[Subjects] => Array
(
[0] => Array
(
[SubjectFull] => DIABETES complications
[Type] => general
)
[1] => Array
(
[SubjectFull] => DIABETIC neuropathies
[Type] => general
)
[2] => Array
(
[SubjectFull] => NEURODEGENERATION
[Type] => general
)
[3] => Array
(
[SubjectFull] => NUTRITION disorders
[Type] => general
)
[4] => Array
(
[SubjectFull] => MITOCHONDRIAL pathology
[Type] => general
)
[5] => Array
(
[SubjectFull] => STREPTOZOTOCIN
[Type] => general
)
[6] => Array
(
[SubjectFull] => SENSORY neurons
[Type] => general
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Nutrient excess and altered mitochondrial proteome and function contribute to neurodegeneration in diabetes
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Chowdhury, Subir K. Roy
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Dobrowsky, Rick T.
)
)
)
[2] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Fernyhough, Paul
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 01
[M] => 11
[Text] => Nov2011
[Type] => published
[Y] => 2011
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-print
[Value] => 15677249
)
)
[Numbering] => Array
(
[0] => Array
(
[Type] => volume
[Value] => 11
)
[1] => Array
(
[Type] => issue
[Value] => 6
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Mitochondrion
[Type] => main
)
)
)
)
)
)
)
|
| IllustrationInfo |