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Serum level of pigment epithelium-derived factor is a marker of atherosclerosis in humans

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العنوان: Serum level of pigment epithelium-derived factor is a marker of atherosclerosis in humans
المؤلفون: Tahara, Nobuhiro1 ntahara@med.kurume-u.ac.jp, Yamagishi, Sho-ichi2 shoichi@med.kurume-u.ac.jp, Tahara, Atsuko1, Nitta, Yoshikazu1, Kodama, Norihiro1, Mizoguchi, Minori1, Mohar, Dilbahar3, Ishibashi, Masatoshi4, Hayabuchi, Naofumi4, Imaizumi, Tsutomu1
المصدر: Atherosclerosis (00219150). Nov2011, Vol. 219 Issue 1, p311-315. 5p.
مصطلحات موضوعية: *SERUM, *EPITHELIUM, *BIOMARKERS, *ATHEROSCLEROSIS, *VASCULITIS, *POSITRON emission tomography, *GLOMERULAR filtration rate, *ENZYME-linked immunosorbent assay
مستخلص: Abstract: Objective: Pigment epithelium-derived factor (PEDF) could play a protective role against atherosclerosis. However, there is no clinical study to examine the relationship between serum level of PEDF and atherosclerosis in humans. Methods/results: The study involved 317 consecutive outpatients in Kurume University Hospital (220 male and 97 female) with a mean age of 62.1±9.1. We examined whether serum level of PEDF were independently associated with vascular inflammation evaluated by [18F]-fluorodeoxyglucose positron emission tomography (FDG-PET) and intima-media thickness (IMT) in carotid artery in humans. Carotid [18F]-FDG uptake, an index of vascular inflammation within the atherosclerotic plaques, was measured as standardized uptake value (SUV). Mean serum PEDF level, carotid SUV and IMT values were 13.5±1.1μg/mL, 1.34±0.19, and 0.71±0.15mm, respectively. In multiple stepwise regression analysis, estimated glomerular filtration rate (p <0.001), males (p <0.001), homeostasis model assessment of insulin resistance index (p <0.05), heart rate (p <0.05), triglycerides (p <0.05), carotid IMT (p <0.05), waist circumference (p <0.05) and carotid SUV (p <0.05) were independently correlated to PEDF level (R 2 =0.332). Conclusion: The present study reveals that serum level of PEDF is independently associated with vascular inflammation and IMT, thus suggesting that PEDF level is a novel biomarker that could reflect atherosclerosis in humans. [Copyright &y& Elsevier]
قاعدة البيانات: Academic Search Index
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Array ( [Name] => Abstract [Label] => Abstract [Group] => Ab [Data] => Abstract: Objective: Pigment epithelium-derived factor (PEDF) could play a protective role against atherosclerosis. However, there is no clinical study to examine the relationship between serum level of PEDF and atherosclerosis in humans. Methods/results: The study involved 317 consecutive outpatients in Kurume University Hospital (220 male and 97 female) with a mean age of 62.1&#177;9.1. We examined whether serum level of PEDF were independently associated with vascular inflammation evaluated by [18F]-fluorodeoxyglucose positron emission tomography (FDG-PET) and intima-media thickness (IMT) in carotid artery in humans. Carotid [18F]-FDG uptake, an index of vascular inflammation within the atherosclerotic plaques, was measured as standardized uptake value (SUV). Mean serum PEDF level, carotid SUV and IMT values were 13.5&#177;1.1μg/mL, 1.34&#177;0.19, and 0.71&#177;0.15mm, respectively. In multiple stepwise regression analysis, estimated glomerular filtration rate (p &lt;0.001), males (p &lt;0.001), homeostasis model assessment of insulin resistance index (p &lt;0.05), heart rate (p &lt;0.05), triglycerides (p &lt;0.05), carotid IMT (p &lt;0.05), waist circumference (p &lt;0.05) and carotid SUV (p &lt;0.05) were independently correlated to PEDF level (R 2 =0.332). Conclusion: The present study reveals that serum level of PEDF is independently associated with vascular inflammation and IMT, thus suggesting that PEDF level is a novel biomarker that could reflect atherosclerosis in humans. [Copyright &amp;y&amp; Elsevier] )
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