دورية أكاديمية
Differences in Molecular Pathologic Characteristics of Pancreatic Adenocarcinoma between Egyptian and Moroccan Patients.
| العنوان: | Differences in Molecular Pathologic Characteristics of Pancreatic Adenocarcinoma between Egyptian and Moroccan Patients. |
|---|---|
| المؤلفون: | Robinson, Sara, Soliman, Amr S.1 asoliman@umich.edu, Karkouri, Mehdi2, Omer, Hoda Gad3, Greenson, Joel F.4 |
| المصدر: | Middle East Journal of Cancer. 2010, Vol. 1 Issue 1, p27-36. 10p. 4 Charts. |
| مصطلحات موضوعية: | *PANCREATIC cancer, *MOLECULAR pathology, *TUMORS, *ADENOCARCINOMA |
| مصطلحات جغرافية: | MOROCCO, EGYPT |
| مستخلص: | Introduction: Pancreatic cancer has not been well studied, especially in developing countries. Materials and Methods: We studied the variations in genetic mutations in pancreatic adenocarcinoma between Moroccan and Egyptian populations. The molecular pathology of 30 tumors from a large hospital in Casablanca, Morocco were examined and compared with the findings of 44 tumors from the Gharbiah Governate in Egypt. K-ras mutations in codons12 and 13 in addition to p53 mutations in exons 5-8 were evaluated. Results: Overall, differences in the rates of K-ras mutations were not statistically significant (48.00 and 34.09%, respectively); however differences in rates of p53 mutations were statistically significant with p53 mutations more common in Moroccan tumors than in Egyptian tumors (46.67 and 16.28%, respectively). G→T mutations of the K-ras gene were most commonly seen Egyptian tumors, whereas G→Amutations were the most common type of mutations in Moroccan tumors. Logistic regression analysis showed that a p53 mutation in any exon as well as a p53 mutation in exon 5 predicted the country of residence and those mutations occurred more frequently in Moroccan patients. Conclusion: Our study shows that differences exist within the Arab population in the molecular pathology of both the K-ras and p53 genes. Further studies are necessary to clarify the differences in molecular pathways of pancreatic cancer in the Middle East and to investigate the role of environmental and/or genetic factors related to those pathways. [ABSTRACT FROM AUTHOR] |
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