دورية أكاديمية
Uncoupling JAK3 activation induces apoptosis in human lymphoid cancer cells via regulating critical survival pathways
| العنوان: | Uncoupling JAK3 activation induces apoptosis in human lymphoid cancer cells via regulating critical survival pathways |
|---|---|
| المؤلفون: | Nagy, Zsuzsanna S.1 znagy@utep.edu, Ross, Jeremy A.1, Rodriguez, Georgialina1, Bader, Julia2, Dimmock, Jonathan3, Kirken, Robert A.1 |
| المصدر: | FEBS Letters. Apr2010, Vol. 584 Issue 8, p1515-1520. 6p. |
| مصطلحات موضوعية: | *MEMBRANE proteins, *PROTEIN-tyrosine kinases, *APOPTOSIS, *ENZYME inhibitors, *CANCER treatment, *GENETIC regulation, *INTERLEUKIN-2, *PROTEIN microarrays, *LYMPHOCYTIC leukemia |
| مستخلص: | Abstract: In the current work, we report that specific inhibition of Janus tyrosine kinase (JAK3) via NC1153 induces apoptosis of certain leukemia/lymphoma cell lines. Affymetrix microarray profiling following NC1153 treatment unveiled JAK3 dependent survival modulating pathways (p53, TGF-β, TNFR and ER stress) in Kit225 cells. IL-2 responsive NC1153 target genes were regulated in human JAK3 positive, but not in JAK3 negative lymphoid tumor cells. Moreover, primary lymphoma samples revealed that a number of these genes were reciprocally regulated during disease progression and JAK3 inhibition suggesting that downstream targets of JAK3 could be exploited in the development of novel cancer treatment regimes. [Copyright &y& Elsevier] |
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