دورية أكاديمية
Dynamic Contrast-Enhanced Ultrasonography Combined With LR-M Classification Criteria for Differentiating Malignant Liver Nodules at High Risk for Hepatocellular Carcinoma.
| العنوان: | Dynamic Contrast-Enhanced Ultrasonography Combined With LR-M Classification Criteria for Differentiating Malignant Liver Nodules at High Risk for Hepatocellular Carcinoma. |
|---|---|
| المؤلفون: | Qiu, Shibo1 (AUTHOR), Ding, Jianmin1 (AUTHOR) djmzyn1982@sina.com, Wang, Yandong1 (AUTHOR), Zhou, Hongyu1 (AUTHOR), Zhao, Lin1 (AUTHOR), Zhao, Lei1 (AUTHOR), Zhou, Yan1 (AUTHOR), Fu, Yaling1 (AUTHOR), Jing, Xiang1 (AUTHOR) |
| المصدر: | Ultrasound in Medicine & Biology. Jul2024, Vol. 50 Issue 7, p1028-1033. 6p. |
| مصطلحات موضوعية: | *HEPATOCELLULAR carcinoma, *ULTRASONIC imaging, *MEDIAN (Mathematics), *LIVER, *CLASSIFICATION |
| مستخلص: | We aimed to investigate the value of quantitative parameters derived from dynamic contrast-enhanced ultrasonography (DCE-US) and a combination of these quantitative parameters with the LR-M classification criteria in distinguishing hepatocellular carcinoma (HCC) nodules and non-HCC malignancies. HCC and non-HCC malignant nodules were grouped using pathologic results, and each nodule was classified using CEUS LI-RADS 2017. Quantitative CEUS analysis of each nodule was performed using VueBox, and quantitative parameters were compared between the HCC and non-HCC groups. The diagnostic efficacy of the LR-5 category for HCC was analyzed using the LR-M classification criteria along with time-related quantitative parameters. Of the 190 malignant liver nodules, 137 and 53 were HCCs and non-HCC malignancies, respectively. The median values of quantitative parameters RT (rise time), TTP (time to peak), mTTl (mean transit time local), and FT (fall time) in the non-HCC malignant group were lower than those in the HCC group, with p < 0.05. There was a statistically significant difference in WiAUC (wash-in area under the curve), WoAUC (wash-out area under the curve), WiWoAUC (wash-in and wash-out area under the curve), and WoR (wash-out rate) values between HCC and non-HCC malignant groups, with p < 0.05. Using LR-M washout time <60 s and FT ≤21.2 s as the new diagnostic standard, the LR-5 category showed a sensitivity of 83.9%, specificity of 96.2%, and positive predictive value of 98.3% for HCC diagnosis. DCE-US can facilitate the distinction of HCCs and non-HCC malignancies. Non-HCC malignancies present with earlier peak enhancement and more rapid and marked washout than HCC nodules. The combination of the LR-M classification criteria and FT ≤21.2 s can significantly improve the diagnostic sensitivity of the LR-5 category for HCC. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: | Academic Search Index |
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