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Prognostic nutritional index and serum lactate dehydrogenase predict the prognosis of nasopharyngeal carcinoma patients who received intensity-modulated radiation therapy.

التفاصيل البيبلوغرافية
العنوان: Prognostic nutritional index and serum lactate dehydrogenase predict the prognosis of nasopharyngeal carcinoma patients who received intensity-modulated radiation therapy.
المؤلفون: Zhang, Chunxia1 (AUTHOR), Zhan, Zhouwei2 (AUTHOR), Fang, Yunxiang3 (AUTHOR), Ruan, Yuanyuan3 (AUTHOR), Lin, Mingan3 (AUTHOR), Dai, Zhisen4 (AUTHOR), Zhang, Yanping4 (AUTHOR), Yang, Shanshan3 (AUTHOR), Xiao, Shuxiang3 (AUTHOR), Chen, Bijuan5 (AUTHOR) chenbijuan90@163.com
المصدر: Journal of Cancer Research & Clinical Oncology. Dec2023, Vol. 149 Issue 20, p17795-17805. 11p.
مصطلحات موضوعية: *INTENSITY modulated radiotherapy, *LACTATE dehydrogenase, *NASOPHARYNX cancer, *PROGRESSION-free survival, *SURVIVAL rate, NASOPHARYNX tumors
مستخلص: Purpose: This research aimed to evaluate the prognostic significance of baseline prognostic nutritional index (PNI) and lactate dehydrogenase (LDH) for the outcome of individuals diagnosed with non-metastatic nasopharyngeal carcinoma (NPC). Methods: A retrospective analysis was conducted on data from 810 patients with non-metastatic NPC who underwent intensity-modulated radiation therapy (IMRT) with or without chemotherapy. The best cut-offs for PNI and LDH were identified by X-tile software to be 48.5 and 150, respectively. To find the independent prognostic factors for survival outcomes, univariate and multivariate regression analyses were conducted, and AUCs were used to compare their prognostic values. Results: Multivariate analysis revealed that patients with PNI > 48.5 had better overall survival (OS) (HR: 0.502, P < 0.001), progression-free survival (PFS) (HR: 0.618, P < 0.001), and distant metastasis-free survival (DMFS) (HR: 0.637, P = 0.005). Higher LDH was associated with poorer OS (HR: 1.798, P < 0.001), PFS (HR: 1.671, P < 0.001), and DMFS (HR: 1.756, P < 0.001). The combination of low PNI and high LDH in non-metastatic NPC patients was correlated with poor OS (P < 0.001), PFS (P < 0.001), and DMFS (P < 0.001). The combination of PNI and LDH had the highest AUCs for predicting OS, PFS, and DMFS. Conclusions: PNI and LDH might become valuable predictors of the prognosis of non-metastatic NPC patients undergoing IMRT with or without chemotherapy. Prognostic accuracy can be enhanced by combining PNI and LDH. [ABSTRACT FROM AUTHOR]
قاعدة البيانات: Academic Search Index
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