دورية أكاديمية
Leptomeningeal Metastases in Melanoma Patients: An Update on and Future Perspectives for Diagnosis and Treatment.
| العنوان: | Leptomeningeal Metastases in Melanoma Patients: An Update on and Future Perspectives for Diagnosis and Treatment. |
|---|---|
| المؤلفون: | Steininger, Julian1 (AUTHOR) frankfriedrich.gellrich@ukdd.de, Gellrich, Frank Friedrich1 (AUTHOR) dana.westphal@ukdd.de, Engellandt, Kay2 (AUTHOR) kay.engellandt@ukdd.de, Meinhardt, Matthias3 (AUTHOR) matthias.meinhardt@ukdd.de, Westphal, Dana1 (AUTHOR) stefan.beissert@ukdd.de, Beissert, Stefan1 (AUTHOR) friedegund.meier@ukdd.de, Meier, Friedegund1,4 (AUTHOR), Glitza Oliva, Isabella C.5 (AUTHOR) icglitza@mdanderson.org |
| المصدر: | International Journal of Molecular Sciences. Jul2023, Vol. 24 Issue 14, p11443. 20p. |
| مصطلحات موضوعية: | *DIAGNOSIS, *METASTASIS, *MELANOMA, *TUMOR microenvironment, *SPINAL infusions, *BLOOD-brain barrier |
| مستخلص: | Leptomeningeal disease (LMD) is a devastating complication of cancer with a particularly poor prognosis. Among solid tumours, malignant melanoma (MM) has one of the highest rates of metastasis to the leptomeninges, with approximately 10–15% of patients with advanced disease developing LMD. Tumour cells that metastasise to the brain have unique properties that allow them to cross the blood–brain barrier, evade the immune system, and survive in the brain microenvironment. Metastatic colonisation is achieved through dynamic communication between metastatic cells and the tumour microenvironment, resulting in a tumour-permissive milieu. Despite advances in treatment options, the incidence of LMD appears to be increasing and current treatment modalities have a limited impact on survival. This review provides an overview of the biology of LMD, diagnosis and current treatment approaches for MM patients with LMD, and an overview of ongoing clinical trials. Despite the still limited efficacy of current therapies, there is hope that emerging treatments will improve the outcomes for patients with LMD. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: | Academic Search Index |
Full Text Finder | ResultId |
1 |
|---|---|
| Header |
asx Academic Search Index 169324331 1377 6 Academic Journal academicJournal 1376.7646484375 |
| PLink |
https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=asx&AN=169324331&custid=s6537998&authtype=sso |
| FullText |
Array
(
[Availability] => 0
)
Array ( [0] => Array ( [Url] => https://resolver.ebscohost.com/openurl?custid=s6537998&groupid=main&authtype=ip,guest&sid=EBSCO:asx&genre=article&issn=16616596&ISBN=&volume=24&issue=14&date=20230715&spage=11443&pages=11443-11462&title=International Journal of Molecular Sciences&atitle=Leptomeningeal%20Metastases%20in%20Melanoma%20Patients%3A%20An%20Update%20on%20and%20Future%20Perspectives%20for%20Diagnosis%20and%20Treatment.&id=DOI:10.3390/ijms241411443 [Name] => Full Text Finder (s6537998api) [Category] => fullText [Text] => Full Text Finder [Icon] => https://imageserver.ebscohost.com/branding/images/FTF.gif [MouseOverText] => Full Text Finder ) ) |
| Items |
Array
(
[Name] => Title
[Label] => Title
[Group] => Ti
[Data] => Leptomeningeal Metastases in Melanoma Patients: An Update on and Future Perspectives for Diagnosis and Treatment.
)
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Steininger%2C+Julian%22">Steininger, Julian</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> frankfriedrich.gellrich@ukdd.de</i><br /><searchLink fieldCode="AR" term="%22Gellrich%2C+Frank+Friedrich%22">Gellrich, Frank Friedrich</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> dana.westphal@ukdd.de</i><br /><searchLink fieldCode="AR" term="%22Engellandt%2C+Kay%22">Engellandt, Kay</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> kay.engellandt@ukdd.de</i><br /><searchLink fieldCode="AR" term="%22Meinhardt%2C+Matthias%22">Meinhardt, Matthias</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> matthias.meinhardt@ukdd.de</i><br /><searchLink fieldCode="AR" term="%22Westphal%2C+Dana%22">Westphal, Dana</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> stefan.beissert@ukdd.de</i><br /><searchLink fieldCode="AR" term="%22Beissert%2C+Stefan%22">Beissert, Stefan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> friedegund.meier@ukdd.de</i><br /><searchLink fieldCode="AR" term="%22Meier%2C+Friedegund%22">Meier, Friedegund</searchLink><relatesTo>1,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Glitza+Oliva%2C+Isabella+C%2E%22">Glitza Oliva, Isabella C.</searchLink><relatesTo>5</relatesTo> (AUTHOR)<i> icglitza@mdanderson.org</i> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => <searchLink fieldCode="JN" term="%22International+Journal+of+Molecular+Sciences%22">International Journal of Molecular Sciences</searchLink>. Jul2023, Vol. 24 Issue 14, p11443. 20p. ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => *<searchLink fieldCode="DE" term="%22DIAGNOSIS%22">DIAGNOSIS</searchLink><br />*<searchLink fieldCode="DE" term="%22METASTASIS%22">METASTASIS</searchLink><br />*<searchLink fieldCode="DE" term="%22MELANOMA%22">MELANOMA</searchLink><br />*<searchLink fieldCode="DE" term="%22TUMOR+microenvironment%22">TUMOR microenvironment</searchLink><br />*<searchLink fieldCode="DE" term="%22SPINAL+infusions%22">SPINAL infusions</searchLink><br />*<searchLink fieldCode="DE" term="%22BLOOD-brain+barrier%22">BLOOD-brain barrier</searchLink> ) Array ( [Name] => Abstract [Label] => Abstract [Group] => Ab [Data] => Leptomeningeal disease (LMD) is a devastating complication of cancer with a particularly poor prognosis. Among solid tumours, malignant melanoma (MM) has one of the highest rates of metastasis to the leptomeninges, with approximately 10–15% of patients with advanced disease developing LMD. Tumour cells that metastasise to the brain have unique properties that allow them to cross the blood–brain barrier, evade the immune system, and survive in the brain microenvironment. Metastatic colonisation is achieved through dynamic communication between metastatic cells and the tumour microenvironment, resulting in a tumour-permissive milieu. Despite advances in treatment options, the incidence of LMD appears to be increasing and current treatment modalities have a limited impact on survival. This review provides an overview of the biology of LMD, diagnosis and current treatment approaches for MM patients with LMD, and an overview of ongoing clinical trials. Despite the still limited efficacy of current therapies, there is hope that emerging treatments will improve the outcomes for patients with LMD. [ABSTRACT FROM AUTHOR] ) |
| RecordInfo |
Array
(
[BibEntity] => Array
(
[Identifiers] => Array
(
[0] => Array
(
[Type] => doi
[Value] => 10.3390/ijms241411443
)
)
[Languages] => Array
(
[0] => Array
(
[Code] => eng
[Text] => English
)
)
[PhysicalDescription] => Array
(
[Pagination] => Array
(
[PageCount] => 20
[StartPage] => 11443
)
)
[Subjects] => Array
(
[0] => Array
(
[SubjectFull] => DIAGNOSIS
[Type] => general
)
[1] => Array
(
[SubjectFull] => METASTASIS
[Type] => general
)
[2] => Array
(
[SubjectFull] => MELANOMA
[Type] => general
)
[3] => Array
(
[SubjectFull] => TUMOR microenvironment
[Type] => general
)
[4] => Array
(
[SubjectFull] => SPINAL infusions
[Type] => general
)
[5] => Array
(
[SubjectFull] => BLOOD-brain barrier
[Type] => general
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Leptomeningeal Metastases in Melanoma Patients: An Update on and Future Perspectives for Diagnosis and Treatment.
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Steininger, Julian
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Gellrich, Frank Friedrich
)
)
)
[2] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Engellandt, Kay
)
)
)
[3] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Meinhardt, Matthias
)
)
)
[4] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Westphal, Dana
)
)
)
[5] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Beissert, Stefan
)
)
)
[6] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Meier, Friedegund
)
)
)
[7] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Glitza Oliva, Isabella C.
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 15
[M] => 07
[Text] => Jul2023
[Type] => published
[Y] => 2023
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-print
[Value] => 16616596
)
)
[Numbering] => Array
(
[0] => Array
(
[Type] => volume
[Value] => 24
)
[1] => Array
(
[Type] => issue
[Value] => 14
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => International Journal of Molecular Sciences
[Type] => main
)
)
)
)
)
)
)
|
| IllustrationInfo |