دورية أكاديمية
أعرض في EDS

The natural history of histological changes in microscopic colitis.

التفاصيل البيبلوغرافية
العنوان: The natural history of histological changes in microscopic colitis.
المؤلفون: Sehgal, Kanika1,2 (AUTHOR), Tome, June3 (AUTHOR), Kamboj, Amrit K.4 (AUTHOR), Dierkhising, Ross A.5 (AUTHOR), Pardi, Darrell S.6 (AUTHOR), Khanna, Sahil7 (AUTHOR) Khanna.sahil@mayo.edu
المصدر: Therapeutic Advances in Gastroenterology. 4/27/2023, p1-10. 10p.
مصطلحات موضوعية: *NATURAL history, *COLITIS, *PROPORTIONAL hazards models, *THERAPEUTICS
الشركة/الكيان: MAYO Clinic
مستخلص: Background: Microscopic colitis (MC) causes chronic diarrhea. It has two histologic subtypes: lymphocytic colitis (LC) and collagenous colitis (CC). Little is known about the natural progression of disease with time and with treatment. Objectives: We aimed to assess histological changes over time. Design: We designed a retrospective study including adults diagnosed with MC from January 1992 to January 2020 at Mayo Clinic. Methods: Pathology reports were reviewed until 31 October 2020. Histological assessments at least 8 weeks apart were considered as adequate follow-up. Histological change from one subtype to the other and resolution were tracked with univariate and multivariable Cox proportional hazards models. Results: Overall, 416 patients with a median age at diagnosis of 63.9 years with >1 histopathological assessment were identified. Histology at initial diagnosis was CC in 218 (52.4%) patients and LC in 198 (47.6%). No medications were associated with a histological change. However, histological resolution was more likely with the use of aspirin [hazard ratio (HR): 2.10, 95% confidence interval (CI): 1.34–3.31, p = 0.001) and proton-pump inhibitors (PPIs; HR: 2.01, 95% CI: 1.34–3.02, p = 0.001). Histological resolution was more likely with budesonide treatment (HR: 1.86, 95% CI: 1.16–3.00, p = 0.010) and less likely with mesalamine (HR: 0.40, 95% CI: 0.19–0.83, p = 0.014), compared to medications such as prednisone, loperamide, and bismuth. Patients with CC were less likely to change their histology compared to patients with LC (HR: 0.24, 95% CI: 0.14–0.42, p < 0.001). There was no difference in histological resolution between the two subtypes (HR: 0.70, 95% CI: 0.47–1.05, p = 0.084). Conclusion: Patients with LC have a higher chance of changing their histology as compared to CC. However, histological resolution was associated with the use of PPIs and aspirin, and treatment with budesonide. [ABSTRACT FROM AUTHOR]
قاعدة البيانات: Academic Search Index
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