دورية أكاديمية

Main Morphological Characteristics of Tubular Polymeric Scaffolds to Promote Peripheral Nerve Regeneration—A Scoping Review.

التفاصيل البيبلوغرافية
العنوان: Main Morphological Characteristics of Tubular Polymeric Scaffolds to Promote Peripheral Nerve Regeneration—A Scoping Review.
المؤلفون: Apablaza, Josefa Alarcón1,2 (AUTHOR) josefa.alarcon@ufrontera.cl, Lezcano, María Florencia1,3,4 (AUTHOR) florencia.lezcano@ufrontera.cl, Lopez Marquez, Alex5 (AUTHOR) alexlopezmarquez@gmail.com, Godoy Sánchez, Karina6,7 (AUTHOR) karina.godoy@ufrontera.cl, Oporto, Gonzalo H.1,3 (AUTHOR) gonzalo.oporto@ufrontera.cl, Dias, Fernando José1,3 (AUTHOR) fernando.dias@ufrontera.cl
المصدر: Polymers (20734360). Aug2021, Vol. 13 Issue 15, p2563-2563. 1p.
مصطلحات موضوعية: *NERVOUS system regeneration, *METAL scaffolding, *PERIPHERAL nervous system, *RF values (Chromatography), *DIGITAL libraries
مستخلص: The "nerve guide conduits" (NGC) used in nerve regeneration must mimic the natural environment for proper cell behavior. Objective: To describe the main morphological characteristics of polymeric NGC to promote nerve regeneration. Methods: A scoping review was performed following the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) criteria in the PubMed, Web of Science, Science Direct, and Scientific Electronic Library Online (SciELO) databases. Primary studies that considered/evaluated morphological characteristics of NGC to promote nerve regeneration were included. Result: A total of 704 studies were found, of which 52 were selected. The NGC main morphological characteristics found in the literature were: (I) NGC diameter affects the mechanical properties of the scaffold. (II) Wall thickness of NGC determines the exchange of nutrients, molecules, and neurotrophins between the internal and external environment; and influences the mechanical properties and biodegradation, similarly to NGC (III) porosity, (IV) pore size, and (V) pore distribution. The (VI) alignment of the NGC fibers influences the phenotype of cells involved in nerve regeneration. In addition, the (VII) thickness of the polymeric fiber influences neurite extension and orientation. Conclusions: An NGC should have its diameter adjusted to the nerve with wall thickness, porosity, pore size, and distribution of pores, to favor vascularization, permeability, and exchange of nutrients, and retention of neurotrophic factors, also favoring its mechanical properties and biodegradability. [ABSTRACT FROM AUTHOR]
قاعدة البيانات: Academic Search Index
ResultId 1
Header asx
Academic Search Index
151785012
1203
6
Academic Journal
academicJournal
1203.20532226563
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=asx&AN=151785012&custid=s6537998&authtype=sso
FullText Array ( [Availability] => 0 )
Array ( [0] => Array ( [Url] => https://resolver.ebscohost.com/openurl?custid=s6537998&groupid=main&authtype=ip,guest&sid=EBSCO:asx&genre=article&issn=20734360&ISBN=&volume=13&issue=15&date=20210801&spage=2563&pages=2563-2563&title=Polymers (20734360)&atitle=Main%20Morphological%20Characteristics%20of%20Tubular%20Polymeric%20Scaffolds%20to%20Promote%20Peripheral%20Nerve%20Regeneration%E2%80%94A%20Scoping%20Review.&id=DOI:10.3390/polym13152563 [Name] => Full Text Finder (s6537998api) [Category] => fullText [Text] => Full Text Finder [Icon] => https://imageserver.ebscohost.com/branding/images/FTF.gif [MouseOverText] => Full Text Finder ) )
Items Array ( [Name] => Title [Label] => Title [Group] => Ti [Data] => Main Morphological Characteristics of Tubular Polymeric Scaffolds to Promote Peripheral Nerve Regeneration—A Scoping Review. )
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Apablaza%2C+Josefa+Alarcón%22">Apablaza, Josefa Alarcón</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> josefa.alarcon@ufrontera.cl</i><br /><searchLink fieldCode="AR" term="%22Lezcano%2C+María+Florencia%22">Lezcano, María Florencia</searchLink><relatesTo>1,3,4</relatesTo> (AUTHOR)<i> florencia.lezcano@ufrontera.cl</i><br /><searchLink fieldCode="AR" term="%22Lopez+Marquez%2C+Alex%22">Lopez Marquez, Alex</searchLink><relatesTo>5</relatesTo> (AUTHOR)<i> alexlopezmarquez@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Godoy+Sánchez%2C+Karina%22">Godoy Sánchez, Karina</searchLink><relatesTo>6,7</relatesTo> (AUTHOR)<i> karina.godoy@ufrontera.cl</i><br /><searchLink fieldCode="AR" term="%22Oporto%2C+Gonzalo+H%2E%22">Oporto, Gonzalo H.</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<i> gonzalo.oporto@ufrontera.cl</i><br /><searchLink fieldCode="AR" term="%22Dias%2C+Fernando+José%22">Dias, Fernando José</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<i> fernando.dias@ufrontera.cl</i> )
Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => <searchLink fieldCode="JN" term="%22Polymers+%2820734360%29%22">Polymers (20734360)</searchLink>. Aug2021, Vol. 13 Issue 15, p2563-2563. 1p. )
Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => *<searchLink fieldCode="DE" term="%22NERVOUS+system+regeneration%22">NERVOUS system regeneration</searchLink><br />*<searchLink fieldCode="DE" term="%22METAL+scaffolding%22">METAL scaffolding</searchLink><br />*<searchLink fieldCode="DE" term="%22PERIPHERAL+nervous+system%22">PERIPHERAL nervous system</searchLink><br />*<searchLink fieldCode="DE" term="%22RF+values+%28Chromatography%29%22">RF values (Chromatography)</searchLink><br />*<searchLink fieldCode="DE" term="%22DIGITAL+libraries%22">DIGITAL libraries</searchLink> )
Array ( [Name] => Abstract [Label] => Abstract [Group] => Ab [Data] => The "nerve guide conduits" (NGC) used in nerve regeneration must mimic the natural environment for proper cell behavior. Objective: To describe the main morphological characteristics of polymeric NGC to promote nerve regeneration. Methods: A scoping review was performed following the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) criteria in the PubMed, Web of Science, Science Direct, and Scientific Electronic Library Online (SciELO) databases. Primary studies that considered/evaluated morphological characteristics of NGC to promote nerve regeneration were included. Result: A total of 704 studies were found, of which 52 were selected. The NGC main morphological characteristics found in the literature were: (I) NGC diameter affects the mechanical properties of the scaffold. (II) Wall thickness of NGC determines the exchange of nutrients, molecules, and neurotrophins between the internal and external environment; and influences the mechanical properties and biodegradation, similarly to NGC (III) porosity, (IV) pore size, and (V) pore distribution. The (VI) alignment of the NGC fibers influences the phenotype of cells involved in nerve regeneration. In addition, the (VII) thickness of the polymeric fiber influences neurite extension and orientation. Conclusions: An NGC should have its diameter adjusted to the nerve with wall thickness, porosity, pore size, and distribution of pores, to favor vascularization, permeability, and exchange of nutrients, and retention of neurotrophic factors, also favoring its mechanical properties and biodegradability. [ABSTRACT FROM AUTHOR] )
RecordInfo Array ( [BibEntity] => Array ( [Identifiers] => Array ( [0] => Array ( [Type] => doi [Value] => 10.3390/polym13152563 ) ) [Languages] => Array ( [0] => Array ( [Code] => eng [Text] => English ) ) [PhysicalDescription] => Array ( [Pagination] => Array ( [PageCount] => 1 [StartPage] => 2563 ) ) [Subjects] => Array ( [0] => Array ( [SubjectFull] => NERVOUS system regeneration [Type] => general ) [1] => Array ( [SubjectFull] => METAL scaffolding [Type] => general ) [2] => Array ( [SubjectFull] => PERIPHERAL nervous system [Type] => general ) [3] => Array ( [SubjectFull] => RF values (Chromatography) [Type] => general ) [4] => Array ( [SubjectFull] => DIGITAL libraries [Type] => general ) ) [Titles] => Array ( [0] => Array ( [TitleFull] => Main Morphological Characteristics of Tubular Polymeric Scaffolds to Promote Peripheral Nerve Regeneration—A Scoping Review. [Type] => main ) ) ) [BibRelationships] => Array ( [HasContributorRelationships] => Array ( [0] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Apablaza, Josefa Alarcón ) ) ) [1] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Lezcano, María Florencia ) ) ) [2] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Lopez Marquez, Alex ) ) ) [3] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Godoy Sánchez, Karina ) ) ) [4] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Oporto, Gonzalo H. ) ) ) [5] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Dias, Fernando José ) ) ) ) [IsPartOfRelationships] => Array ( [0] => Array ( [BibEntity] => Array ( [Dates] => Array ( [0] => Array ( [D] => 01 [M] => 08 [Text] => Aug2021 [Type] => published [Y] => 2021 ) ) [Identifiers] => Array ( [0] => Array ( [Type] => issn-print [Value] => 20734360 ) ) [Numbering] => Array ( [0] => Array ( [Type] => volume [Value] => 13 ) [1] => Array ( [Type] => issue [Value] => 15 ) ) [Titles] => Array ( [0] => Array ( [TitleFull] => Polymers (20734360) [Type] => main ) ) ) ) ) ) )
IllustrationInfo