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Oncological resection, myasthenia gravis and staging as prognostic factors in thymic tumours: a Chilean case series.

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العنوان: Oncological resection, myasthenia gravis and staging as prognostic factors in thymic tumours: a Chilean case series.
المؤلفون: Salas, Patricio1, Solovera, Maria Eliana1, Bannura, Felipe1, Muñoz-Medel, Matias2, Cordova-Delgado, Miguel2, Sanchez, Cesar2, Ibañez, Carolina2, Garrido, Marcelo2, Koch, Erica2, Acevedo, Francisco2, Mondaca, Sebastian2, Nervi, Bruno2, Madrid, Jorge2, Peña, Jose2, Pinto, Mauricio P.2, Valbuena, José3, Galindo, Hector2 investigacion.onco@uc.cl
المصدر: Ecancermedicalscience. 2021, Vol. 15 Issue 1162-1202, p1-8. 8p.
مصطلحات موضوعية: *PROGNOSIS, *MYASTHENIA gravis, *THYMUS tumors, *OVERALL survival, *SURVIVAL rate, *TUMORS
مصطلحات جغرافية: UNITED States
مستخلص: Background: Thymic epithelial tumours are rare and highly heterogeneous. Reports from the United States suggest an overall incidence of 0.15 per 100,000/year. In contrast, the incidence of these tumours in Latin America is largely unknown and reports are scarce, somewhat limited to case reports. Methods: Herein, we report a series of 38 thymic tumours from a single institution, retrospectively incorporated into this study. Patient characteristics and outcomes including age, sex, stage, paraneoplastic syndromes, treatment regimens and the date of decease were obtained from medical records. Results: Most cases in our series were females and young age (<50 years old) and early stage by Masaoka-Koga or the Moran staging systems. Also, a 34% of patients had myasthenia gravis (MG). Next, we analysed overall survival rates in our series and found that the quality of surgery (R0, R1 or R2), MG status and staging (Masaoka-Koga, Moran or TNM) were prognostic factors. Finally, we compared our data to larger thymic tumour series. Conclusions: Overall, our study confirms complete surgical resection as the standard, most effective treatment for thymic epithelial tumours. Also, the Masaoka-Koga staging system remains as a reliable prognostic factor but also the Moran staging system should be considered for thymomas. [ABSTRACT FROM AUTHOR]
قاعدة البيانات: Academic Search Index
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