دورية أكاديمية
Changes of matrix metalloproteinase-9 and its tissue inhibitor (TIMP-1) after autologous hematopoietic stem cell transplantation in multiple sclerosis
| العنوان: | Changes of matrix metalloproteinase-9 and its tissue inhibitor (TIMP-1) after autologous hematopoietic stem cell transplantation in multiple sclerosis |
|---|---|
| المؤلفون: | Blanco, Yolanda1, Saiz, Albert1 asaiz@clinic.ub.es, Carreras, Enric2, Graus, Francesc1 |
| المصدر: | Journal of Neuroimmunology. Aug2004, Vol. 153 Issue 1/2, p190-194. 5p. |
| مصطلحات موضوعية: | *TRANSPLANTATION of organs, tissues, etc., *MULTIPLE sclerosis, *STEM cells, *MATRICES (Mathematics) |
| مستخلص: | Elevated levels of matrix metalloproteinase-9 (MMP-9) associates with predictors of multiple sclerosis (MS) activity. We analysed serum levels and mRNA expression of MMP-9 and its inhibitor TIMP-1 in peripheral mononuclear cells of 14 MS patients after autologous hematopoietic stem cell transplantation (AHSCT). All but 2 patients stabilized after AHSCT. A significant decrease of MMP-9 levels was seen up to 36 months after AHSCT. TIMP-1 levels did not change. MMP-9 mRNA levels correlated with the CD4+ T cell count (p<0.0001). The significant and persistent change in MMP-9 activity after AHSCT may be caused in part by the effect of AHSCT in the CD4+ T cell count. [Copyright &y& Elsevier] |
| قاعدة البيانات: | Academic Search Index |
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